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Articles by J.O. Amupitan
Total Records ( 3 ) for J.O. Amupitan
  J.D. Habila , F.O. Shode , G.I. Ndukwe , J.O. Amupitan and A.J. Nok
  Background: Natural product compounds are the source of numerous chemotherapeutic agents. Investigations were carried out to evaluate the therapeutic properties of a C-3 modified oleanolic acid, 3β-acetoxyoleanolic acid (JH23), in the continue search for lead compounds. Results: The well-in-plate agar diffusion method used for the inhibition zone determination, showed that compound JH23 had a more enhanced activity as compared to JH16 (oleanolic acid) the parent nucleus, on most of the test organism; Candida guielemondi (JH23, 23±0.04; JH16, 22±0.03), Candida albicans (JH23, 29±0.05; JH16, 21±0.12), Candida krusei (JH23, 26±0.04; JH16, 23±0.001), Candida tropicalis (JH23, 30±0.02; JH16, 23±0.01), Trichophyton tonsurans (JH23, 29±0.03; JH16, 19±0.02) and Microsporum canis (30±0.01; JH16, 16±0.04). Conclusion: The results showed that functionality modification of organic compounds could lead to compounds with enhanced bioactivity.
  Z. Ladan , E.M. Okonkwo , J.O. Amupitan , E.O. Ladan and B. Aina
  Hyptis spicigera seed oil was characterized using GC-MS and UV-VIS spectrometry for its fatty acid composition, tocopherol content and physicochemical properties. The oil content was 21% while unsaturated fatty acids were linoleic acid (71.85%) and Palmitic acid (16.06%) as predominant fatty acids. Tocopherol content was 186.15 mg mL-1 while Vitamin A was absent. This study showed potentials of Hyptis spicigera seed oil to have high oxidative stability which could be suitable for food and beverage as well as other industrial applications while the tocopherol content could improve human health.
  R.G. Ayo , J.O. Amupitan and A.O. Oyewale
  The aim of the study was to scientifically validate the claims that C. nigricans is used in traditional medicine for the treatment of skin diseases, infections and wounds. The leaves of Cassia nigricans is said to be used in traditional medicine for the treatment of peptic ulcer, gastro-intestinal disorders, diarrhoea and skin diseases. The glycoside present in the methanol extract of the leaves was hydrolysed using dilute hydrochloric acid. A silica gel column of the resulting aglycone (using petroleum ether:ethyl acetate mixtures) gave a white amorphous powder, identified as steroidal ester by means of spectral analysis. The antimicrobial activity of the steroidal ester was investigated against Staphylococcus aureus, Streptococcus pyogenes, Corynebacterium pyogenes, Bacillus subtilis, Salmonella typhi, Escherichia coli, Pseudomonas aeruginosa, Candida albicans, Neisseria gonorrhoeae and Klebsiella pneumoniae using agar diffusion technique. The results showed that the compound was effective against all the test organisms and the minimum inhibitory concentration was found to be 2x103 μg mL-1.
 
 
 
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