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Articles by J.O. Adebayo
Total Records ( 2 ) for J.O. Adebayo
  O.M. Iniaghe , S.O. Malomo and J.O. Adebayo
  Proximate composition and phytochemical constituents of leaves of Acalypha hispida, Acalypha marginata and Acalypha racemosa were investigated. Proximate composition of leaves of Acalypha hispida showed that it contained moisture (11.02%), crude fat (6.15%), ash (10.32%), crude protein (13.78%), crude fibre (10.25%) and carbohydrate (44.48%). Similarly, Acalypha marginata showed that it contained moisture (10.83%), crude fat (5.60%), ash (15.68%), crude protein (18.15%), crude fibre (11.50%) and carbohydrate (38.24%); while Acalypha racemosa contained moisture (11.91%), crude fat (6.30%), ash (13.14%), crude protein (16.19%), crude fibre (7.20%) and carbohydrate (45.26%). The phytochemicals detected in both aqueous and methanolic extracts of each of the different species of leaves were the same and are phenolics, flavonoids, hydroxyanthraquinones and saponins. Steroids and phlobatannins were detected in Acalypha hispida and Acalypha racemosa, while glycoside was detected only in Acalypha hispida. All these results indicate that the leaves of these Acalypha species contains nutrients and mineral elements that may be useful in nutrition. The presence of some phytochemicals like saponins and flavonoids explained the medicinal action of the plant encountered in its therapeutic uses.
  J.O. Adebayo , A.H. Zailani and E.A. Balogun
  The effects of daily oral administration of ethanolic extract of Clerodendrum violaceum leaves (13 mg kg-1 body weight) for 5 days on some liver function indices of Plasmodium berghei-infected mice were investigated. The evaluations were done on days 3, 8 and 14 post-infection. The indices studied include serum albumin, globulin, total protein, total bilirubin and conjugated bilirubin concentrations with the specific activities of Glutamate Pyruvate Transaminase (GPT), Glutamate Oxaloacetate Transaminase (GOT), Alkaline Phosphatase (ALP) and γ-Glutamyl Transferase (GGT) in the liver and serum. Treatment of infected mice with extract was able to significantly (p<0.05) ameliorate the alterations in all the parameters observed in infected untreated mice, comparing favourably with chloroquine treatment. Administration of extract to uninfected mice showed no significant effect (p>0.05) on the parameters studied both in the serum and liver compared to the uninfected untreated control, except that it significantly increased (p<0.05) liver GPT activity. The results of this study suggest that the ethanolic extract of Clerodendrum violaceum leaves is able to considerably reverse the alterations caused by malaria infection in all parameters studied and is relatively non-toxic. Further studies on Clerodendrum violaceum as a source of antimalarial remedy are indicated on the basis of these results.
 
 
 
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