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Articles by J.K.P. Edward
Total Records ( 3 ) for J.K.P. Edward
  C. Chellaram , R.S. Sreenivasan , S. Jonesh , T.P. Anand and J.K.P. Edward
  To test the antibacterial effect of the extracts of Drupa margariticola obtained using low to high polar solvents, like ethyl acetate, dichloromethane, acetone and methanol. Partial purification of the active crude extract was carried out using column chromatography employing a step gradient solvent system. A maximum inhibition of 7 mm against E. coli was shown by the 100% acetone column purified fractions of D. margariticola at a concentration of 0.125 mg. Minimum Inhibitory Concentration values were found to be lower for the 100% acetone fraction for pathogens, E. coli (0.05 mg), Klebsiella pnuemoniae (0.05 mg), Pseudomonas aerogenosa (0.07 mg) and Streptococcus pnuemoniae (0.07 mg). Thus 100% acetonated fraction of the extract of D. margariticola was considered as potent antibacterial compounds against some human pathogens. The antibacterial potential of the mollusc, Drupa maragariticola becomes a corner stone for the future development of novel biologically active compounds.
  C. Chellaram , S. Jonesh , T. Prem Anand and J.K.P. Edward
  The aim of this study, the coral reef associated mollusc Drupa margariticola was screened for their insecticidal activity against a dreadful rice pest Sitophilus oryzae, The insecticidal activity of the crude and partially purified extracts of D. margariticola was tested using contact bioassay by the modified method. The extracts of acetone, ethyl acetate and dichloromethane caused 100% (10), 80.67% (8.67±1.25) and 80.0% (8±0.82) mortality respectively against S. oryzae at a concentration of 50 mg mL-1. The 100% acetone column purified fractions of extracts was found cause 100% at a concentration of 20 mg. The ED50 value of crude and column purified acetone extracts of D. margariticola was found to be lower 21.08 and 4.09 mg mL-1, respectively. The extract of D. margariticola screened for insecticidal activity clearly shows that the extract of acetone may possess some biologically active compounds. The exact route of entry is doubtful, which, in future can be cleared with studies on the mode of action of the extract tested.
  S. Anbuselvi , C. Chellaram , S. Jonesh , L. Jayanthi and J.K.P. Edward
  Whole body meats of mollusc, Trochus tentorium was extracted with four solvents such as acetone, ethyl acetate, dichloromethane and methanol. Maximum antibacterial inhibition zone was exhibited from acetone crude extract of T. tentorium against human pathogen (Streptococcus pneumoniae 8 mm). The 100% column purified acetone fraction of T. tentorium showed higher activity against human pathogens like Klebsiella pneumoniae (7 mm). The minimal inhibitory concentration of the 100% acetone fraction of T. tentorium was found to be lower for the pathogens, E. coli (0.08 mg), Streptococcus pnuemoniae (0.08 mg), Staphylococcus aureus (0.09 mg) and Vibrio cholerae (0.09 mg), hence 100% acetone fraction of the extract of T. tentorium was deemed as potent bioactive compounds against those pathogens.
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