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Articles by J.I. Sigit
Total Records ( 3 ) for J.I. Sigit
  L. Amalia , E.Y. Sukandar , R.M.A. Roesli and J.I. Sigit
  The aim of this study was to determine the effect of ethanol extract of kucai bulbs on serum nitric oxide (NO) levels in rats, in an attempt to study the mechanism of antihypertensive action. The measurement of NO level was conducted by Griess colorimetric assay. The male Wistar rats were divided randomly into three groups; the first group was treated with kucai extract of 100 mg kg-1 body weight (kucai-treated group); the second group with isosorbide dinitrate (ISDN) of 0.18 mg kg-1 body weight (ISDN-treated group) and the third group with vehicle only (control group). The results showed that at 30 min (T30) the mean NO level in kucai-treated group increased significantly (138.69 ± 169.38%) compared to baseline (T0); similarly, in ISDN-treated group, the mean NO level increased (212.08 ± 140.01%) significantly. At T90, average NO levels in kucai-treated group was significantly higher than those in control group (p = 0.018), while those in ISDN-treated group were not significantly higher than those in control group (p = 0.436). Compared to kucai-treated group, NO levels in ISDN-treated group at T90 was significantly different (p = 0.028). From this study it can be concluded that ethanol extract of kucai bulbs increased significantly serum NO level in experimental rats. Therefore, it is preassumed that antihypertensive effect shown by kucai is, one of which, due to mechanism of vasodilator action. The present results showed that kucai increased NO levels and this might be one mechanism of blood pressure lowering action of kucai.
  E.Y. Sukandar , H. Permana , I.K. Adnyana , J.I. Sigit , R.A. Ilyas , P. Hasimun and D. Mardiyah
  Turmeric (Curcuma longa L.) and garlic (Allium sativum Lin.) are known as traditional drugs that can cure several diseases such as dyslipidemia and diabetes. Many studies on individual usages of garlic and turmeric have been done previously. Present preclinical study showed that combination of both substances gave a better result compared to their individual usage. This research was aimed to evaluate the efficacy and safety of turmeric and garlic extracts combination as antihyperglycemic and antihyperlipidemic agents for type-2 diabetes-dyslipidemia. Three doses were evaluated: 1.2, 1.6 and 2.4 g, daily. It was found that the garlic-curcuma combination could reduce plasma glucose level and HbA1C as well as improve the lipid profile. Among those 3 dosages, the dose of 2.4 g decreased fasting glucose level, 2 h postprandial glucose level, HbA1C, total cholesterol, low density lipoprotein, triglyceride and body mass index more than the two other dosages. This dose level also increased high density lipoprotein higher than the other two dosages. There was no significant adverse event observed during the study. The treatment also showed no side effect on kidney and liver functions as well as the blood composition of all subjects.
  E. Sovia , E.Y. Sukandar , J.I. Sigit and L.D.N. Sasongko
  Turmeric and garlic have been known to have antibiabetes effect. Therefore, both can be used as an alternative therapy in the treatment of diabetes. However, their mechanism of action in lowering blood glucose is still unknown. In this study, we investigated the effect of curcuminoid, S-methyl cysteine and its combination on blood glucose level and improvement of pancreatic damage in alloxan induced diabetes mice. Curcuminoid, S-methyl cysteine and their combination were given for 21 days. Then, blood glucose levels were measured and mice were sacrificed and pancreas were isolated for immunohistochemical analysis. The results showed a significant difference of blood glucose levels between control group with treatment group. Adminstration of curcuminoid, S-methyl cysteine and its combination can lower blood glucose levels significantly. Immunohistochemical analysis of pancreas showed a darker color intensity in the group given by curcuminoid and S-methyl cysteine compared with the control group. While the group given by its combination showed minor change compared with the control group. In conclusion curcuminoid, S-methyl cysteine and its combination can lower blood glucose levels. Curcuminoid and S-methyl cysteine could repair damage of pancreas caused by the induction of alloxan while its combination showed only a minor improvement.
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