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Articles by J.I. Ndem
Total Records ( 2 ) for J.I. Ndem
  F.E. Uboh , M.I. Akpanabiatu , Y. Alozie , E.E. Edet , J.I. Ndem and P.E. Ebong
  Comparative effect of vitamins A and E on gasoline vapours haematotoxicity, growth-depression and weight-loss was assessed in male Wistar albino rats. The rats were exposed to gasoline vapours (17.8±2.6 cm3/h/m3/day), 6 h/day, 6 days/week for 20 weeks. Vitamins A (retinol) and E(α-tocopherol) at prophylactic dosage (400 and 200 IU/kg/day, respectively) were orally administered to the rats separately, in the last 2 weeks of exposure. The levels of haemoglobin (Hb), haematocrit or Packed Cell Volume (PCV), Red Blood Cells (RBC), growth-rate and weight-gain in the rats exposed to the vapours were significantly lower (p<0.05) compared, respectively to the levels obtained for control rats. On the other hand, the levels of White Blood Cells (WBC) in the test rats were significantly higher (p<0.05) compared, respectively with the level obtained for male control rats. These observations indicate that exposure to gasoline vapours may cause haematotoxicity, growth-depression and weight-loss in male rats. However, administration of vitamins A and E was observed to produce a significant recovery (p<0.05) in haematotoxicity, growth-depression and weight-loss observed to be associated with exposure to gasoline vapours, although, the rats administered with vitamin E were noted to respond more favourably than those administered with vitamin A. This suggests that although retinol and α-tocopherol may be used to reverse or prevent haematotoxicity, growth-depression and weight-loss in subjects exposed to gasoline vapours, the reversal potency of α-tocopherol is higher than that of retinol.
  J.I. Ndem , M.I. Akpanabiatu and E.U. Essien
  Periwinkle (Tympanotonus fustcatus), Crayfish (cambarellus diminutus) and Bonka fish (Ethimalosa fimbriata) are local marine food sources of omega-3 fatty acid. Groundnut oil, corn oil and soybean oil are notably high in omega-6 fatty acids. The present study compared changes in haematological and biochemical indices in rats fed with local marine foods (periwinkle, bonka fish and crayfish) and vegetable oils (groundnut, soybean and corn oil) enriched meals. Rats in all the experimental groups had a significant (P< 0.05) increase in the Hb, PCV and RBC values and a non-significant decrease (P> 0.05) in the WBC counts, when compared with the control. The results of the lipid profile of the test groups on omega-3 and omega-6 enriched pellets were significantly lower than that of control but the HDL-C concentrations were significantly higher in these groups. Similarly rats on pellets enriched with local marine foods (periwinkle, bonka fish and crayfish) considered to be rich in omega-3 fatty acid had significant decreased (P < 0.05) cholesterol, and HDL – C concentrations while TG, VLDL and LDL-C increased significantly when compared with control. These results suggest that consumption of diet enriched with periwinkle, bonka fish, crayfish and oil rich in omega-3 and omega-6 polyunsaturated fatty acids may prevent cardiovascular disease. This may be one mayor reason for low incident of coronary heart disease among the poor rural people that consumed basically periwinkle, bonka fish and cray fish as their main sources of protein.
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