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Articles by J.H. Chen
Total Records ( 3 ) for J.H. Chen
  C. Ju , B. Xu , Y. Lu , X.J. Mo , T. Zhang , S.B Chen , F. Liu , S.J. Cui , W. Liu , J.H. Chen , Z. Feng , J.X. Peng and W. Hu
  Schistosomiasis ranks as the second most serious parasitic disease worldwide after malaria. More than 250 million people are infected with schistosomes in the tropics or subtropics. The treatment and control of schistosomiasis which is a major neglected tropical parasitic disease, depends almost exclusively on chemotherapy with Praziquantel (PZQ). Current serologic diagnostic assays have shown that schistosome specific antibodies in human serum may remain for at least 1 year after cure. Repeated administration of PZQ for a long time might induce drug resistance to the parasite which is a big challenge for strategizing for the prevention and control of schistosomiasis. As schistosome eggs represent the most pathogenic form causing the disease, it is essential to determine if and how the level of antibodies against schistosome Soluble Egg Antigens (SEA) is affected by PZQ treatment. In this study, researchers carried out an immunomic analysis to profile Schistosoma japonicum SEA reacting with pooled human serum samples of pre and post treatment with PZQ by two dimensional electrophoresis combined with Western blotting. A total of 67 protein spots that were serologically recognized by serum samples were successfully subjected to mass spectrometric analysis. Of them, 37 different characterized proteins were successfully identified. Furthermore, of 67 protein spots, the reactivity of 49 protein spots to sera was reduced 20 weeks after PZQ treatment whereas only 5 spots showed increases in the intensity of recognition by post treatment sera. The present study suggested that chemotherapy with PZQ mainly affects the intensity of serological recognition of S. japonicum SEA. The immunomic proteins that were identified may facilitate a better understanding of the egg induced pathogenesis of schistosomiasis and host-parasite interplay and may provide potential targets for the diagnosis and evaluation of treatment for the disease as well.
  E.S. Richardson , C.S. Yoo and J.H. Chen
  The timing and location of autoignition can be highly sensitive to turbulent fluctuations of composition. Second-order Conditional Moment Closure (CMC) provides transport equations for conditional (co)variances in turbulent reacting flows. CMC equations accounting for compressibility and differential diffusion are analyzed using data from direct numerical simulation of an autoignitive lifted turbulent hydrogen jet flame [C.S. Yoo, R. Sankaran, J.H. Chen, Three-dimensional direct numerical simulation of turbulent lifted hydrogen/air jet flame in a heated coflow. Part 1. J. Fluid. Mech., (2008)]. At the flame base, second-order moments were required to accurately model the conditional reaction rates. However, over 80% of the second-order reaction rate component was obtainable with a small subset (16%) of the species-temperature covariances. The balance of the second-order CMC equation showed that turbulent transport across spatial composition gradients initiates generation of conditional variances.
  R. Iv , Q. He , H.P. Wang , J. Jin , Y. Chen and J.H. Chen

Background: We sought investigate the relationship between serum level of sCD30 and recipient/graft survival rates, rejection types, as well as other prognostic factors among Chinese kidney transplant patients.

Materials and methods: We performed enzyme-linked immunosorbent assays of serum sCD30 levels in duplicate among retrospective cohort of 707 renal transplant patients.

Results: The incidences of rejection increased in relation to the pretransplant sCD30 level. The reversal rates of rejection were 100%, 90.6%, and 78.6% for the low, intermediate, and high sCD30 groups. This observation suggested that high levels of sCD30 and pretransplant panel-reactive antibody (PRA)-positive patients are risk factors for acute rejection with odds ratios of 6.862 and 1.756. High sCD30 was an independent risk factor for functional graft survival. The 5-year graft survival rates were 99.39% ± 6.1%, 93.11% ± 1.93%, and 82.07% ± 3.97% among the low, intermediate, and high sCD30 groups, while the 5-year recipient survival rates were 89.25% ± 2.41%, 91.82% ± 1.64%, and 88.85% ± 2.36%, respectively. Increased sCD30 levels were observed among patients who were PRA-positive, cytomegalovirus antigens or antibodies positive, on long-term dialysis, and ≤ 20 years old.

Conclusions: Pretransplant sCD30 serum levels reflect immune status.
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