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Articles by J.E. Ataman
Total Records ( 4 ) for J.E. Ataman
  E.S. Orhue , M. Idu , J.E. Ataman and L.E. Ebite
  This study investigated the possible toxicity of consumption of the leaf by determining a variety of serum biochemical parameters in liver and renal function tests, haematological and physical parameters. A 5 week repeated dose toxicity of Jatropha tanjorensis leave powder was carried out in rabbits. Forty animals, male and female, were administered feed mash plus ground J. tanjorensis leaf powder in graded concentrations of 0, 5, 10 and 25%. All rabbits survived at the end of the study and results showed no significant alteration in average body weight in the treatment groups when compared with the control group. The haemoglobin, hematocrit, platelets and platelet cell distribution width in the female group, showed significant increase between the control and the treated groups. This is an indication of an improved bone marrow function. No severe histopathologic indicator was recorded.
  J.E. Ataman , D.B. Grillo , E.K.I. Omongbai , M. Idu , F. Amaechina , V. Okonji and B.A. Ayinde
  Phytochemistry of Momordica charantia L. leaves revealed the presence of flavonoids and tannins. The hypoglycaemic effect of M. charantia leaves as well as the plant`s effect on rats` weight under different treatment patterns was assessed. Forty wistar rats weighing between 140-250 g were categorized into eight experimental groups of five wistar rats per group. The efficacy of 250 mg kg-1 methanolic extract of the leaves on alloxan-induced diabetic rats showed mild hypoglycaemic effect within 24 h. There was no evidence to establish that parenteral route is more efficacious than the oral route of administration of the treatment plant. The experimental rats that was alloxan-treated to induce hyperglycaemia and treated with 500 mg kg-1 of methanolic extract of the treatment plant as well as those induced with alloxan without treatment with methanolic extract of M. charantia showed significant loss in weight (p < 0.05) after twelve weeks. The controls as well as those treated exclusively with methanolic extract of treatment plant without alloxan treatment had significant weight gain (p < 0.05). The results generally indicate that methanolic extract of the leaves of M. charantia has hypoglycaemic potential especially on long-term use.
  J.E. Ataman , M. Idu , E.A. Odia , E.K.I. Omogbai , F. Amaechina , A.O. Akhigbe and L.E. Ebite
  The toxicity of powdered Stachytarpheta jamaicensis (L.) Vahl. leaves, known for treating different ailments such as diabetes, hypertension and bacterial infections in some Nigerian communities, was investigated in rats. Twenty Wister rats (male and female) were fed with different graded mixtures of Pfizer feed mash and the leaf powder. The animals were weighed and divided into four groups of three treatment groups and one control group with each group consisting of five rats. The rats were administered different concentrations of powdered S. jamaicensis leaves mixed with different amount of feed mash.i.e. 75, 50 and 5 g of S. jamaicensis was mixed with 25, 50 and 75 g of normal feed mash. The control was fed only with feed mash all through the period of experiment. The results obtained showed slight variation on the physical signs/body appearance of the animals and mild histopathlogic 1esions such as congestion, fatty changes and necrosis in selective tissues such as the liver, blood vessels, kidney, lung and testis but the brain, eyes, intestines (small and large) and heart tissues were essentially normal. S. jamaicensis seem to cause mild non-dose dependent systemic toxicity in some specific tissues.
  A.O. Akhigbe , M. Idu , E.S. Orhue , J.E. Ataman and S.O. Ehimwenman
  Toxicological study of Jatropha tanjorensis leaves was conducted by evaluating changes in weight, biochemical and ultrasonographic parameters of rabbits that have been administered varying concentrations (0, 5, 10 and 25%) of the ground leaves mixed with feed-mash for a period of 30 days. There was no significant difference (p<0.05) in weight of rabbits. Renal function tests revealed that there was a significant reduction of serum urea concentration in the male rabbits (p<0.05) from 38.33 in group C to 18.33 in group D. This suggests that the amount of J. tanjorensis plant powder used in this study could interfere positively with the filtration function of the kidney in rabbits. The ultrasound picture of kidney, heart and spleen showed no significant change from the control, where as there was reduction in the size of the liver with increased echogenicity when compared with the control. This may be an indication of hepatic toxicity.
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