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Articles by J.E. Ataman
Total Records ( 3 ) for J.E. Ataman
  M. Idu , E.K.I. Omogbai , F. Amaechina and J.E. Ataman
  The effect of the aqueous extract of the leaves of Stachytarpheta jamaicensis (L.) Vahl. on blood pressure was investigated in anaesthetized normotensive male rabbits. The extract was administered intravenously at doses ranging from 2.5-80 mg kg-1. The extract caused a dose-dependent fall in blood pressure and heart rate. 2.5 mg kg-1 of the extract reduced the Mean Arterial Pressure (MAP) from the initial 102.8±4.2 to 96.6±7.3 mmHg and the Heart Rate (HR) from 398.3±8.3 beats/min to 373.1±9.7 beats/min. 80 mg kg-1 reduced MAP and HR to 38.9±3.1 mmHg and 178.3±83.7 beats/min, respectively. Neither atropine nor promethazine inhibited the hypotensive effect of the extract. The acute hypotensive effect of the extract may be partly due to the negative chronotropic effect or to a direct effect on vascular smooth muscle.
  M. Idu , J.E. Ataman , A.O. Akhigbe , E.K.I. Omogbai , F. Amaechina and E.A. Odia
  Effect of powdered Stachytarpheta jamaicensis L. leaves known for treating different ailments was investigated for toxicity. In the study, twenty Wister rats (male and female) after due acclimatization, were fed with different graded mixtures of feed mash and the treatment plant. The animals were weighed and divided into four groups of three treatment groups and one control group with each group consisting of five rats. The rats were administered different concentrations of powdered S. jamaicensis leaves mixed with different amount of feed mash. i.e., 75, 50 and 25 g of S. jamaicensis was mixed with 25, 50 and 75 g of normal feed mash. The control was fed only with feed mash all through the period of experiment. The results revealed levels of Alkaline Phosphatase (ALP), Serum Glutamate Oxaloacetate Transaminase (SGOT) and Serum Glutamate Pyruvate Transaminase (SGPT) were slightly elevated (p>0.05). Bilirubin levels in all the groups showed slight variation (p>0.05) when compared with control. The ultrasound picture of heart, liver, kidney and spleen showed no significant difference from control. From the results obtained, no significant alteration in the normal serum biochemistry as well as in the echogenic pattern was identified between the control and experimental rats thus suggesting wide therapeutic safety margin in the use of S. jamaicensis.
  J.E. Ataman and M. Idu
  Histopathologic assessment of the effects of 500 mg kg-1 methanolic extract of the leaves of Momordica charantia on liver of wistar rats was carried out. Forty wistar rats of equal sex weighing between 140-250 g were randomly categorised into eight experimental groups of five wistar rats per group. One main control group M and seven treatment groups A1, A2, B1, B2, C1, C2 and D. A1, A2, B1 and B2 groups were treated with alloxan intraperitoneally. However, while A1 group received 500 mg kg-1 (2 mL) of extract treatment, A2, B1 and B2 had no extract treatment. A2 received 2 mL of methanol. C1 group were normoglycaemic rats with no alloxan treatment, but were given 500 mg kg-1 (2 mL) of extract treatment orally. C2 group (also normoglycaemic without alloxan treatment) received 2 mL of methanol in place of extract treatment. The D group had 500 mg kg-1 (2 mL) of extract treatment intraperitoneally without alloxan treatment. Histopathologic assessment revealed acute congestion of the liver with fluid, enlarged portal triad, pericentral vein haemorrhage and centrilobular necrosis in the A1 treatment. A similar but lesser lesion in D treatment was noticed and essentially normal tissues was observed in all other treatments including the C1 tissues that had extract via the oral route. Significant difference (p<0.05) were observed in the Serum Alkaline Phosphatase, L-alanine aminotransferase, L-aspartate aminotransferase, total bilirubin and conjugated bilirubin in the treated rats of the various groups; but the cholesterol levels was not significantly different (p>0.05) from control. The results generally indicate that methanolic extract of the leaves of Momordica charantia Linn is relatively safe when used orally, but parenteral administration suggests need for caution on indiscriminate use because of its potentially hazardous effect on tissues like the liver; especially on long term use.
 
 
 
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