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Articles by J.A. Oguntola
Total Records ( 2 ) for J.A. Oguntola
  L.C. Saalu , A.A. Osinubi , J.A. Oguntola , I.O. Adeneye and A.S. Benebo
  Doxorubicin (DOX), one of the anthracycline antibiotic drugs isolated from the soil fungus Streptomyces peucetius caesius, which has been widely used to treat cancer effectively. It has also been known to induce reproductive abnormalities in males. The implication of natural phenolic compounds in the prevention of many pathologic diseases has been reported. Herein, the ability of polyphenolic-rich Grapefruit Seed Extracts (GSE), to protect rat testis against DOX-induced histomorphometric impairment was investigated. Four groups of Wistar rats were used; The GSE- alone group received intraperitoneal (i.p.) Normal Saline (NS) 2.5 mg kg-1 b.wt. followed by orally GSE 10 mg kg-1 b.wt. daily for 16 weeks. The DOX-alone group were given i.p., DOX 20 mg kg-1 b.wt. as a single dose. The GSE plus DOX-group were similarly given DOX, but also had oral GSE 10 mg kg-1 b.wt. post-treatment for 16 weeks. Another group of rats were each given orally 2.5 mL kg-1 b.wt. peanut oil (vehicle) daily for 16 weeks, after 2.5 mL kg-1 b.wt. normal saline was given as a single dose i.p., to serve as the control. The animals were sacrificed 16 weeks after DOX or NS injections. The testicular toxicity induced by DOX was assessed by histologic and stereologic evaluation of the testis. Present results demonstrated that post-treatment with GSE was capable of reversing the reduction of body and testicular weights as well as the testicular histomorphometric evidences of high dose and delayed DOX toxicity in the animals. The GSE was therefore shown to exert testicular cytorejuvinative effects on rats challenged with DOX.
  L.C. Saalu , P.I. Jewo , O.E. Yama and J.A. Oguntola
  Hydroxyurea (HDU) is approved for reducing the frequency of painful crises and the need for blood transfusions in adults with sickle cell disease who experience recurrent moderate to severe pain. Treatment with HDU is however, associated with known side effects such as cytotoxicity and myelosuppression. In the present study we evaluated the effect of a clinically relevant dose of HDU used in the treatment in sickle cell disease on the seminiferous tubules of rats. Adult male Sprague -Dawley rats were orally treated with 25 mg HDU kg-1 body weight/day for 28 consecutive days. Control rats received the vehicle for HDU which was normal saline 2.5 mL kg-1 body weight. Groups of rats were sacrificed variously on the next day, the 56th and the 112 day after the last dosing with HDU or saline. The testis were recovered, weighed and subjected to histopathology. The gross anatomical parameters assessed included the testicular weights and volumes while stereological parameters estimated includes diameter and cross-sectional area of the seminiferous tubules; number of profiles per unit area and numerical density of seminiferous tubules. The results show that treatment with HDU exhibited significant atrophic degeneration in the seminiferous tubules compared with controls. There was an initial manifestation of progressive worsening of the testicular profiles with passage of time, as the animals sacrificed on day 56 demonstrated greater toxicity than those autopsied a day after day 28. However, the animals sacrificed on day 112 showed some improvement in their testicular profiles, suggesting some degree of self-reversal or recovery of the effect. We conclude that HDU has a deleterious effect on the rat testis even at the clinically relevant dose used in management of sickle cell disease.
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