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Articles by J.A. Ansari
Total Records ( 6 ) for J.A. Ansari
  J.A. Ansari , A. Siraj and N.N. Inamdar
  Parkinson disease is a very common neurodegenerative disease. Most of the drug classes discussed in this review generally acts on the dopaminergic system. Therefore, researchers are attempting to develop drugs which act on non-dopaminergic pathways downstream in the basal ganglia, which are generally involved in the pathophysiology of PD. Compounds that act on noradrenergic, serotinergic, glutamatergic, adenosine, opioid and cannabinoid pathways have been developed so far. Hence, the most preferential symptomatic treatment for PD is levodopa. Due to long-term use, levodopa causes motor complications including involuntary movements and response fluctuations leading to more preferential and cautious prescribing of levodopa. Dopamine agonists can be used as an alternative initial therapy to delay the onset of motor complications but this leads to more dopaminergic adverse events, poorer control of motor symptoms and increased cost. Once motor complications have been developed, adjuvant therapy with dopamine agonists can decrease off time and levodopa dose. Severe fluctuations which are not controlled by oral combination therapy can be controlled with subcutaneous apomorphine injections or infusions.
  J.A. Ansari and N.N. Inamdar
  The usage of plants, plant extracts or plant-derived pure chemicals to treat disease become a therapeutic modality, which has stood the test of time. Today several pharmacological classes of drugs include a natural product prototype. Aspirin, atropine, ephedrine, digoxin, morphine, quinine, reserpine and tubocurarine are a few examples of modern drugs, which were originally discovered through the study of traditional cures and folk knowledge of indigenous people. A team work amongst ethnobotanists, ethnopharmacologists, physicians and phytochemists is must for the fruitful outcome on medicinal plants research. While the ethnopharmacologists have a greater role in the rationalization of combination of activities, the phytochemist’s role will slightly shift towards standardization of herbal medicines.
  J.A. Ansari , S. Ali and M.A. Ansari
  The diseases associated to liver, heart, blood, brain, kidneys, spleen, pancreas, nerves, hormones, fluids and electrolytes, virus, bacteria, protozoa, fungi etc. are paying much attention and numerous research work is been done in respective areas, worldwide metabolic disorders are need to pay an attention. Problems related to liver such as acute or chronic inflammation, toxin-/drug-induced hepatitis, cirrhosis and hepatitis are very common nowadays due to our exposure to different environmental pollutants like chemicals, toxins, viruses etc. For centuries, many herbal drugs and formulations have been used as natural remedies for the prevention and/or treatment of liver diseases and have been popularized world over by leading pharmaceuticals. Due to insufficient scientific-based pharmacological data, most of the herbal formulations cannot be recommended for the treatment of liver diseases. In this review article, an attempt has been made to focus a brief view on few herbal hepatoprotective leads that may be useful to the health professionals, scientists and scholars working the field of pharmacology and therapeutics to develop evidence-based alternative medicine to cure different kinds of liver dysfunctions.
  J.A. Ansari , Mateen Sayyed and Faizan Sayeed
  There is a rapid raise in the metabolic risk factors in the general population and non-alcoholic fatty liver disease has become the most common cause of liver disease worldwide. Early detection of hepatotoxicity is extremely important because continued ingestion of the drug is often associated with a poor prognosis. Insulin resistance play a central role in the pathogenesis of Non Alcoholic Fatty Liver Disease (NAFLD); thus obesity, diabetes and the metabolic syndrome are frequently associated with the disease. Consequently, as these metabolic conditions emerge as major health problems in Western society, it is now accepted that NAFLD is the most common chronic liver condition in the Western world. The pathogenesis of non-alcoholic fatty liver disease is not completely understood and even if insulin resistance is a chief pathogenetic key, many other factors are implicated in both liver fat accumulation and disease progression to non-alcoholic steatohepatitis. There is, as up till now no firm evidence-based treatment for NAFLD. Therapy is currently directed at treating components of the metabolic syndrome which may also be valuable for the liver. Management is further complex by the inability to predict which patients will develop liver-related morbidity and thus benefit from treatment. Data were located, selected and extracted from SCI database, Medline, Pubmed, Highwire and Google Scholar.
  J.A. Ansari
  Drugs are an important reason of hepatotoxicity. In general more than 900 drugs, toxins and herbs have been reported to cause hepatotoxicity and drugs account for 20-40% of all instances of fulminant hepatic failure. Specific therapy against drug-induced hepatotoxicity is limited to the use of N-acetylcysteine in the early phases of paracetamol toxicity. L-carnitine is potentially valuable in cases of valproate toxicity. In general, corticosteroids have no definitive role in treatment. They may prevent the systemic features associated with hypersensitivity or allergic reactions. Cholestyramine can be used for alleviation of pruritus. Ursodeoxycholic acid may be used. Lastly, consulting a hepatologist is always useful for other agents, supportive measures and the increasing use of liver-assist devices as well as emergency liver transplantation are available when drug injury evolves into irreversible liver failure. It is expected that a better understanding of hepatotoxicity mechanisms will lead to the development of more specific and effective forms of therapy in the near future.
  J.A. Ansari and M. Jamil
  Liver is one of the most important organs in the metabolism of food, drugs, endogenous and exogenous substances. Problems related to liver such as acute or chronic inflammation, toxin-/drugs-induced hepatitis, cirrhosis and hepatitis are well-known nowadays due to our exposure to different environmental pollutants like chemicals, toxins, viruses etc. Liver disease can result from dosage-dependent hepatotoxicity or from adverse reactions to drugs used in therapeutic dosage. The anatomical structures of a liver that has undergone partial hepatectomy are therefore distinctly different from those of the original liver. The restoration process of liver volume in humans is initiated by the replication of various types of intra hepatic cells, followed by an increase in cell size. Efforts to develop pharmacologic means for liver protection from damage during regeneration have identified a few molecular targets.
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