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Articles by J.A. Ajiboye
Total Records ( 2 ) for J.A. Ajiboye
  J.K. Akintunde , J.A. Ajiboye , E.O. Siemuri , S.B. Oyelowo , O.J. Sunday , E.O. Abam and A.E. Irondi
  Erectile Dysfunction (ED) occurs in folk men which poses great threat to couples awaiting children. The liver is one of the most vital organs involved in drug detoxification process. However, the concomitant toxic effects of Viagra on liver with other tissues are unknown. The present study was aimed to elucidate the effects of therapeutic doses of orally administered Viagra on the antioxidant defense status of liver, kidney, spleen and lung tissues in healthy rats. Wistar healthy albino Rats were orally administered with various therapeutic doses (20 mg kg-1 b.wt.) of Sildenafil citrate (viagra) for 4 weeks exhibited mild hepatocyte necrosis, periportal cellular infiltration by mononuclear cells and no visible lesions in kidney cells. This is accompanied with non-significant elevated plasma alanine amino transaminase (ALT) and aspartic amino transaminase (AST) levels, decreased hepatic MDA level and increased levels of MDA in kidney, spleen and lung. GSH was increased in liver, kidney, spleen and decreased in lung. CAT and SOD activity were elevated in liver, kidney and spleen. Lung showed high activity of SOD and low activity of CAT. Hence, administration of Viagra potentiates both enzymatic and non-enzymatic antioxidants in liver, kidney and spleen while it may promote inflammatory response in male rats. The present study provides evidence for stabilizing antioxidant defense systems in liver, kidney, spleen and may be a contributory factor for lung inflammatory responses.
  O.G. Arinola , S.O. Nwozo , J.A. Ajiboye and A.H. Oniye
  The consumption and export cassava or cassava product is on the increase, thus more Nigerians are involved in the planting and processing of cassava stems and tubers respectively. Tropical ataxic neuropathy (TAN) and diabetes Mellitus (DM) are among the cassava-cyanide induced conditions in rural Nigerians that engaged in processing and consumption of cassava products. TAN and DM are associated with certain trace elements, therefore this study determines the levels of trace elements (Mg, Fe, Zn, Mn, Cu, Cr, Cd, Pb) and total antioxidant (TAS) in 36 Nigerian cassava processors and 24 controls using spectrophotometric methods. The mean levels of Mg, Pb, Cd, Cr and Cu were not significantly raised in cassava processors compared with the controls. Also, the mean levels of essential trace elements such as Se, Zn, Fe, Mn and TAS were not significantly reduced in cassava processors compared with the controls. Fairly raised levels of toxic metals (Pb and Cd) and reduced levels of nutritionally essential trace elements (Se, Fe and Zn) call for future concern about the health status of long-time cassava processors.
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