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Articles by J.A. Shilpi
Total Records ( 5 ) for J.A. Shilpi
  S.M. Mahbubul Alam , Lucky Yeasmin , M. Nadim Reza , J.A. Shilpi , Firoj Ahmed and M. Jamil Akter
  In the current study on Pharmacokinetic parameter of Chloramphenicol especially emphasizing on binding parameters i.e. association constants, number of binding sites, forces involving in the drug-protein interactions was studied by equilibrium dialysis method. Two types of association constants characterize the binding of the drug on BSA: high affinity association constant (k1) with lower number of binding sites (n1) and low affinity association constant (k2) with higher number of binding sites (n2). The values for k1 and k2 at pH 7.4 and at temperature 25 ° C were found (16.9 ± 0.01)x105 and (4.23 ± 0.04)x105 M ha-1 , respectively and those for n1 and n2 were 1.8 ± 0.3 and 4.6 ± 0.4, respectively. Values of k1 were found to decrease both with the increase of pH from 6.4 to 8.4 and temperature from 25 to 40 ° C. Thermodynamic data indicated that the protein-Chloramphenicol binding is exothermic, entropically driven and spontaneous. Electrostatic, hydrogen bonding, vander Waal`s force and hydrophobic interactions are involved in the binding of Chloramphenicol to BSA.
  S.J. Uddin , J.A. Shilpi , G.M.M. Murshid , A.A. Rahman , M.M. Sarder and M.A. Alam
  The binding of arsenic (As) on bovine serum albumin (BSA) was studied by equilibrium dialysis (ED) method using warfarin sodium (as site-I specific probe) and diazepam (as site-II specific probe) to determine the binding sites of arsenic to BSA. The data obtained showed that the free concentration of warfarin sodium increased very slowly by the addition of arsenic, while the free concentration of diazepam increased rapidly by the addition of arsenic. The free concentration of warfarin was 10.5% in absence of arsenic whereas this release was up to 20% when arsenic was added to BSA with an increasing concentration from 0.5x10-5 to 10x10-5M. The free concentration of diazepam was 11% in absence of arsenic whereas this release was up to 50% when arsenic was added to BSA with an increasing concentration from 0.5x10-5 to 10x10-5M. This site-specific probe displacement data implied that site-I (warfarin site) is low affinity site while site-II (diazepam site) is high affinity site of arsenic to the BSA.
  S.J. Uddin , M.M. Ferdous , R. Rouf , M.S. Alam , M.A.M. Sarkar and J.A. Shilpi
  The methanolic and aqueous extracts of E. fluctuans was evaluated in experimental diarrhoea, induced by castor oil in mice. Both methanolic and aqueous extracts, given orally at the dose, of 250 mg kg-1 body weight, showed significant anti-diarrhoeal activity as compared to that of the control. Both the extracts at the above dose levels also significantly reduced the intestinal transit of charcoal meal in mice. The in vitro antimicrobial activity of the extracts showed variable result. The methanolic extract moderately inhibited the growth of Shigella dysenteriae, Shigella boydii and Shigella flexneri, while the aqueous extract inhibited the growth of Staphylococcus aureus, S. dysenteriae and S. boydii. But both the methanolic and aqueous extracts did not show any significant effect on Escherichia coli and Pseudomonas aerugenosa. All the results indicated that the extract of E. fluctuans possesses anti-diarrhoeal activity.
  J.A. Shilpi , R. Rouf , M.A.M. Sarker , Qamrunnahar , M.M. Ferdous and S.J. Uddin
  The antinociceptive activity of the methanolic extract of the whole plant of Solanum sisymbrifolium Lamk. was investigated using acetic acid-induced writhing model in swiss albino mice. At the doses of 125, 250 and 500 mg kg 1 body weight, the extract showed 44.19, 59.53 and 73.02% writhing inhibition, respectively in test animals which were comparable to that of standard drug aspirin (85.12%) and the results were statistically significant (p<0.001). At the above doses, the extract exhibited significant and dose dependant antinociceptive activity in acetic acid-induced writhing model in mice. Phytochemical investigation of the extract indicated the presence of alkaloid, flavonoids, steroid and tannin.
  M.M. Ahasan , M.M. Billah , M.M. Hasan , K.M.D. Islam and J.A. Shilpi
  Two genetically different related forms of human immunodefficiency virus (HIV), a human lentivirus belonging to the lentivirus family, called HIV-1 and HIV-2, have isolated from patients with AIDS. HIV can be transmitted through contaminated blood and blood products; from a mother to her offspring during pregnancy, childbirth or breast feeding; or through sexual contact. Sexual transmission remains by far the predominant mode of transmission. Vertical and blood borne transmission of HIV are highly predictable and very efficient modes. Sexual transmission of HIV, however, appears to be considerably less efficient and highly variable. During the early period after primary infection with HIV widespread of dissemination of the virus and a sharp decrease in the number of CD4+T cell count occurs. The use of CD4 cell count is an important indicator of disease severity of AIDS. The patients infected with AIDS can be attacked by various opportunistic infections such as pneumonia, Mycobacterium avium complex, cytomegalovirus, microsporidiosis and tuberculosis. The degree of intensity of these diseases can be indicated by measuring the level of enzyme like alkaline phosphatase, alanin aminotransferase and aspartate aminotransferase, lactate dehydrogenase and creatine phosphokinase.
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