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Articles by J. Zhu
Total Records ( 9 ) for J. Zhu
  X Jin , H Mei , X Li , Y Ma , A. h Zeng , Y Wang , X Lu , F Chu , Q Wu and J. Zhu
 

We studied the apoptosis-inducing properties of the antimicrobial peptide cecropin of Musca domestica in human hepatocellular carcinoma cell line BEL-7402 and its underlying mechanism. Proliferation inhibition of the human hepatocellular carcinoma BEL-7402 cells and the human normal liver cells were determined by the MTT assay, and the cell viability was determined by trypan blue dye exclusion assay. The apoptotic tumor cells treated with cecropin were examined by transmission electron microscopy and terminal-deoxynucleotidyl transferase mediated nick end labeling. The apoptosis rate was measured by flow cytometry (FCM) with PI/Annexin-V double staining. Western blot analysis and RT-PCR were used to determine the expression levels of proteins involved in apoptosis, such as Fas, Fas-L, caspase-8, and caspase-3. The experimental results showed that Musca domestica cecropin inhibited the proliferation of human hepatocellular carcinoma BEL-7402 cells in dose-dependent and time-dependent manners, without affecting the proliferation of normal liver cells. FCM showed that the cell apoptosis rates were 5.1 ± 0.11%, 8.1 ± 0.04%, and 10.9 ± 0.15% after the treating with 100 µM cecropin for 24, 48, and 72 h, respectively. The rates of apoptosis were 5.4 ± 0.14% and 8.0 ± 0.13% after the treating with 25 and 50 µM cecropin for 72 h, respectively. Western blot analysis and RT-PCR showed that the apoptosis-related molecules including Fas, Fas-L, caspase-8 and caspase-3 were activated. This study showed that the antimicrobial peptide cecropin-inducing apoptosis in human hepatocellular carcinoma BEL-7402 cells, which might be associated with upregulation of Fas, Fas-L, and caspase-8 and caspase-3 and triggering extrinsic apoptotic pathway.

  S Wang , B Nan , N Zhu and J. Zhu
 

In many biological and other scientific applications, predictors are often naturally grouped. For example, in biological applications, assayed genes or proteins are grouped by biological roles or biological pathways. When studying the dependence of survival outcome on these grouped predictors, it is desirable to select variables at both the group level and the within-group level. In this article, we develop a new method to address the group variable selection problem in the Cox proportional hazards model. Our method not only effectively removes unimportant groups, but also maintains the flexibility of selecting variables within the identified groups. We also show that the new method offers the potential for achieving the asymptotic oracle property.

  A. J Rothman , E Levina and J. Zhu
 

In this paper we propose a new regression interpretation of the Cholesky factor of the covariance matrix, as opposed to the well-known regression interpretation of the Cholesky factor of the inverse covariance, which leads to a new class of regularized covariance estimators suitable for high-dimensional problems. Regularizing the Cholesky factor of the covariance via this regression interpretation always results in a positive definite estimator. In particular, one can obtain a positive definite banded estimator of the covariance matrix at the same computational cost as the popular banded estimator of Bickel & Levina (2008b), which is not guaranteed to be positive definite. We also establish theoretical connections between banding Cholesky factors of the covariance matrix and its inverse and constrained maximum likelihood estimation under the banding constraint, and compare the numerical performance of several methods in simulations and on a sonar data example.

  J. Zhu and D. Sun
  This paper presents an approach based on a conceptualization of combining the neural network based pedo-transfer function (PTF) results with the thin layer concept to explore capillary-pressure-dependent anisotropy in relation to soil texture and soil bulk density. The effects of capillary pressure (or saturation degree) on the hydraulic conductivity anisotropy of unsaturated soils are still poorly understood. The main objective is to examine how anisotropy characteristics are related to the relationships between hydraulic parameters and the basic soil attributes such as texture and bulk density. The hydraulic parameters are correlated with the texture and bulk density based on the pedo-transfer function (PTF) results. It is demonstrated that non-monotonic behavior of the unsaturated soil anisotropy in relation to the capillary pressure is only observed when the saturated hydraulic conductivity and the shape parameter are both related to the particle diameter. Therefore, it is suggested that this behavior is mainly due to the coupled dependence of the layer saturated hydraulic conductivities and the shape factors on the texture and bulk density. The results illustrate that the inter-relationships of soil texture, bulk density, and hydraulic properties may produce vastly different characteristics of anisotropic unsaturated soils.
  Y. Liu , Y.-M. Yang , J. Zhu , H.-Q. Tan , Y. Liang and J.-D. Li
  Aims  To assess the prognostic impact of HbA1c and blood glucose level in patients with acute ST-segment elevation myocardial infarction and without diabetes. The relationship between HbA1c and acute hyperglycaemia was also explored.

Methods and results  We evaluated 4793 ST-segment elevation myocardial infarction patients with baseline HbA1c and three glucose measurements in the first 24 h. First, patients were stratified into quintiles by HbA1c and mean/admission glucose level. A total of 373 deaths (7.8%) occurred at 7 days, and 486 deaths (10.1%) occurred at 30 days. There were no significant differences in 7- and 30-day mortality, and major adverse cardiovascular event rates across HbA1c quintiles (< 34.4 mmol/mol (5.3% ), 34.4 to < 37.7 mmol/mol (5.6%), 37.7 to < 41.0 mmol/mol (5.9% ), 41.0 to < 47.5 mmol/mol (6.5%), and ≥ 47.5 mmol/mol; P for trend > 0.05). The risks of mortality and major adverse cardiovascular events were significantly increased in patients with higher glucose quintiles and lower quintile compared with the middle quintile after multivariable adjustment (P < 0.001). Patients were then reclassified into four groups according to mean/admission glucose and HbA1c levels. The group with elevated glucose and non-elevated HbA1c was associated with the highest mortality and major adverse cardiovascular event risk (P < 0.001).

Conclusions  Unlike acute hyperglycaemia, an elevated HbA1c level was not a risk factor for short-term outcomes in ST-segment elevation myocardial infarction patients without diabetes. Patients with acute hyperglycaemia and non-elevated HbA1c were associated with the worst prognosis. That suggests chronic glycaemic control/HbA1c level may help to recognize stress-induced hyperglycaemia and identify high-risk patients.

  J. Zhu , C. Zi , X.M. Su , L. Liu , Z.D. Du , L. Ye , K.Z. Xie , X.G. Huang , S.L. Wu and W.B. Bao
  The Bactericidal/Permeability-Increasing protein (BPI) plays a very important role in the animal body’s natural defense. It has a series of biological functions such as killing Gram-negative bacteria, the neutralization of endotoxin or lipopolysaccharides, etc. To investigate the effect and mechanism of porcine BPI gene on enterotoxigenic Escherichia coli F18, particularly whether the expression of BPI gene is related to the different breeds. In this study, real-time PCR was used to analyze the expression of BPI gene expression in post-weaning piglets of Yorkshire, Sutai (Resource Population of resistance to E. coli F18) and Meishan. The results showed that there was almost no expression or very low expression of BPI gene in heart, liver, spleen, lung, kidney, stomach, muscle, thymus and lymph nodes but there was a high expression in the duodenum and jejunum and the expression levels were significantly different from those of the other 9 organs. It also showed that the jejunum and duodenum expression of BPI gene in Sutai was significant higher than Yorkshire and Meishan (p<0.05). The researchers can speculate that the expression of BPI gene was significant difference in different breeds. The researchers can further indicates that the expression of the BPI gene in Sutai piglets could be beneficial to the infection of E. coli. BPI gene might have a direct role against diarrhea and edema disease caused by ECF18 in weaned piglets, the resistance was related to the upregulation of BPI gene expression in the intestine. BPI gene can be identified as a genetic marker for future breeding against E. coli and Salmonella related diseases.
  J. Zhu and P. Bettinger
  In this study, three heuristics were developed to assess the quality of forest plans that can be developed and the time required to develop them. The three heuristics include threshold accepting, 1-opt tabu search and a combined heuristic which consisted of threshold accepting, 1-opt tabu search and 2-opt tabu search. The combined heuristic was developed to capitalize on the unique search properties of both threshold accepting and tabu search. Present hypothesis was that each of the three heuristics would produce forest plans of approximately equal solution quality. The three heuristics are assessed using forest plans developed from nine hypothetical landownerships containing various ownership patterns and age class distributions. The combined heuristic found the highest quality forest plans for most problems with older and normal age class distributions. In problems with younger age class distributions, the combined heuristic produced slightly inferior solutions as compared to threshold accepting. The variation in forest plan quality was lowest when using the combined heuristic or threshold accepting, thus these two processes are of value for large-scale forest plan development efforts.
  Q. Zeng , X. Hu , J. Zhu and H. Duan
  This study proposes an algorithm for the decomposition approach of Petri nets based on indexes of places and analyzes the complexity of the given algorithm. The main data structures required and four key functions contained in the algorithm are firstly addressed. It is proved that the proposed decomposition algorithm is a polynomial-time algorithm.
  C.X. Chen , S.C. Li , S.Q. Wang , H.N. Liu , Q.M. Deng , A.P. Zheng , J. Zhu , L.X. Wang and P. Li
  The concept of a “core parent” was proposed by breeders to describe elite lines with both good field performance and high potential for breeding superior new lines. Guichao 2 is one of the most important rice core parents in China. In the present study, Simple Sequence Repeat marker (SSR) based genome-wide screening was performed for Guichao 2, its parents and derivatives to study the genetic diversity and structure of them. A total of 348 polymorphic markers and 833 polymorphic alleles were detected. The Polymorphic Information Content (PIC) value ranged from 0.15 to 0.95 and averaged 0.39. Genetic similarity among the ten varieties varied from 0.751 to 0.926 with an average of 0.842, indicating that the genetic diversity is not abundant. At the whole genome level, Chaoyangzao 18 (30.4%) contributed many more genetic components to Guichao 2 than Guiyangai 49 (16.3%) did. The amount of genetic material transmitted by Guichao 2 to its derivatives varied from 49.7% (Qingliuai) to 59.5% (Fengqingai), with an average of 54.7%. In addition, 78 genomic regions of Guichao 2 were identified as stably inherited by these derivatives, with contribution ratios ranging from 14.29 to 85.71%, with an average of 47.25%. Ten of these regions with the same contribution ratio of 85.1% (RM3412-RM140, RM1339-RM1068, RM6997-RM6172, RM3524-RM3042, RM1388-RM1136, RM1353-RM1243, RM5508-RM3753, RM3395-RM3662, RM3662-RM44 and RM6643-RM2915) were found to be significantly important in the derivative cultivars.
 
 
 
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