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Articles by J. Yuan
Total Records ( 2 ) for J. Yuan
  J. Yuan , A.J. Karimi , S.D. Goodgame , C. Lu , F.J. Mussini and P.W. Waldroup
  A study was conducted to evaluate an herbal methionine replacement product in diets for young broiler chicks. A corn-soybean meal diet that was complete in all respects but methionine was prepared and divided into three aliquots. One was supplemented with 0.30% DL methionine and another was supplemented with the herbal methionine replacement product. Each of these was then blended with the unsupplemented basal diet to provide diets with 0, 0.05, 0.10, 0.15, 0.20, 0.25 and 0.30% of either DL methionine or the herbal methionine replacement product. Each diet was fed to twelve pens of five male broiler type chicks each in electrically heated battery brooders. The diets and tap water were provided for ad libitum feeding from day of hatch to 18 d of age. Analysis of the diets indicated that the methionine activity of the diets with DL methionine was close to expected values but no apparent increase in analyzed methionine activity in diets supplemented with the herbal methionine replacement product. Body weight gain and feed conversion of birds fed the diets with DL methionine were significantly superior to that of birds fed the diets with the herbal methionine replacement product. No significant differences were observed between birds fed the two products for weight of digestive or immune organs when expressed as a percentage of body weight. These data suggest that the herbal methionine replacement product is not suitable for use as a methionine source in diets for young broiler chicks.
  K. Wu , F. Xiang , J. Yuan , Z. Zeng , H. Zhou , S. Chang and Z.K. Chen

Background: We sought to investigate the effects of donor-specific transfusion (DST) combined with rapamycin (RPM) on engraftment and demonstrate the mechanisms.

Methods: B6 was treated with DST (on day −8) combined with RPM (from day −7 to −1, 1.5 μL/g per day). On day 0, B6 splenocytes were harvested to coculture with Balb/c splenocytes pretreated with mitomycin C in 1-way mixed lymphocyte cultures (MLC). After 48 hours, the proliferation, we measured apoptosis and the CD4+CD25+ T-cell ratio of cultured cells. The heterotopic cardiac transplantation model was performed from Balb/c to B6 using the recipients pretreated with this protocol. On day 0, RPM was withdrawn and the transplantations performed. The mean survival time (MST) of the grafts evaluated and in vitro assays measured.

Results: Both in vitro and in vivo, the protocol suppressed the proliferation of splenocytes as well as enhanced apoptosis and the CD4+CD25+ T-cell ratio. The MST of the grafts was 35 ± 14.4 days.

Conclusions: Our study showed that DST combined with RPM prolonged cardiac allograft survival even if we withdrew immunosuppressants after transplantation. This result may be associated with inhibition of T-cell proliferation. We also demonstrated that RPM expanded CD4+CD25+ T cells and increased splenocyte apoptosis.
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