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Articles by J. Ye
Total Records ( 6 ) for J. Ye
  J Yin , A Zuberi , Z Gao , D Liu , Z Liu and J. Ye

The extract of plant Shilianhua (SLH; Sinocrassula indica Berge) is a component in a commercial product for control of blood glucose. However, it remains to be investigated whether the SLH extract enhances insulin sensitivity in a model of type 2 diabetes. To address this question, the SLH crude extract was fractionated into four parts on the basis of polarity, and bioactivities of each part were tested in cells. One of the fractions, F100, exhibited a strong activity in the stimulation of glucose consumption in vitro. Glucose consumption was induced significantly by F100 in 3T3-L1 adipocytes, L6 myotubes, and H4IIE hepatocytes in the absence of insulin. F100 also increased insulin-stimulated glucose consumption in L6 myotubes and H4IIE hepatocytes. It increased insulin-independent glucose uptake in 3T3-L1 adipocytes and insulin-dependent glucose uptake in L6 cells. The glucose transporter-1 (GLUT1) protein was induced in 3T3-L1 cells, and the GLUT4 protein was induced in L6 cells by F100. Mechanism study indicated that F100 induced GSK-3β phosphorylation, which was comparable with that induced by insulin. Additionally, the transcriptional activity of NF-B was inhibited by F100. In RAW 264.7 macrophages, mRNA expression of NF-B target genes (TNF and MCP-1) was suppressed by F100. In KK.Cg-Ay/+ mice, F100 decreased fasting insulin and blood glucose and improved insulin tolerance significantly. We conclude that the F100 may be a bioactive component in the SLH plant. It promotes glucose metabolism in vitro and in vivo. Inhibition of GSK-3β and NF-B may be the potential mechanism.

  S. PENG , L. CHEN , J.G. QIN , J. HOU , N. YU , Z. LONG , E. LI and J. YE
  A 9-week feeding experiment was conducted to evaluate the effects of dietary vitamin E supplementation on growth, lipid peroxidation and fatty acid composition of black sea bream fed oxidized oil. The FL and OL diets contained fresh fish oil and oxidized oil, respectively, without additional vitamin E supplementation. Another four α-tocopherol levels (150, 250, 450 and 800 mg kg−1 diet) were used within the OL diet, giving a total of six experimental diets. Fish were hand-fed to apparent satiation twice daily. At end of the trial, the weight gain and survival rate of fish were significantly reduced by diets with oxidized oil, whereas hepatosomatic index was remarkably high in fish fed oxidized oil diet. However, vitamin E supplementation to diet significantly improved growth performance and increased vitamin E content in the liver. Although, liver thiobarbituric acid reactive substances and docosahexaenoic acid were significantly increased by dietary oxidized oil, their levels were reduced by dietary vitamin E supplementation. Our results indicate that the fish were performing the best at intermediate concentrations of α-tocopherol and a dose of >150 mg α-tocopherol kg−1 diet could reduce lipid peroxidation and improve fish growth performance when oxidized oils exist in diet.
  L.L. Shi and J. Ye
  Aiming at complexity and uncertainty of relation between vibration and fault types of turbine, a new method of fault diagnosis of turbine was proposed based on an improved vague cosine similarity measure. Compared with the previous cosine similarity measures for vague sets, the improved cosine similarity measure has more information to deal with vagueness and uncertainty problems by considering truth-membership functions, false-membership functions and hesitancy degree of vague sets and then it can overcome the undefined problem when the degree of membership and degree of non-membership are zero, respectively. Then, the cosine similarity measure was applied to fault diagnosis of turbine. For this fault diagnosis, the matter-element models of the turbine fault were built according to diagnostics derived from specialists’ knowledge of practical experience and then through the vague cosine similarity measure between a fault-testing sample and fault knowledge samples, the vibration fault is determined according to the maximum cosine similarity measure value. The fault-diagnosis example of the turbine shows that the proposed method is simple and effective.
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