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Articles by J. Yadav
Total Records ( 4 ) for J. Yadav
  J.P. Verma , J. Yadav and Kavindra Nath Tiwari
  Field-based experiments were conducted to evaluate the combined application of Rhizobium sp. BHURC01 and plant growth promoting rhizobacteria on chickpea production in two consecutive years. A positive influence of plant growth promoting rhizobactria and Rhizobium sp. BHURC01 on nodulation, plant biomass, nitrogen and phosphorus in nodule, grain and straw and yield related parameter were recorded in two year of field experiments. The maximum significant increase in nodule number, dry weight of nodule, root and shoot were recorded in co-inoculation of Rhizobium sp. BHURC01 and Pseudomonas fluorescens followed by co-inoculation of Rhizobium sp. BHURC01, Azotobacter chroococcum and Bacillus megaterium over uninoculated control in two year of field study while, nitrogen and phosphorus content increase in nodules, grain and straw. The Rhizobium sp. BHURC01 and P. fluorescens showed significant increase in all parameter due to more available nitrogen by Rhizobium sp. BHURC01 and more available of phosphorus, iron and plant hormones like indole-3-acetic acid (IAA) and antifungal activity by P. fluorescens in comparison of B. megaterium and A. chroococcum. Therefore, co-inoculation of Rhizobium sp. BHURC01 and P. fluorescens could be effective biofertilizer for chickpea (Cicer arietinum L.) production.
  V.K. Dwivedi , M. Chaudhary , A. Soni , J. Yadav , A. Tariq , M.R. Siddiqui , A. Ahmad and P.S. Negi
  The present study was to investigate the comparative efficacy of ceftriaxone and a fixed dose combination of ceftriaxone plus sulbactam along with VRP1034 (Sulbactomax) in cerebrospinal fluid (CSF) of meningitis induced rat model. Eighteen rats were divided into three groups of six rats each. Meningitis were induced by MRSA strain (log 106 cfu mL-1). Group I was infected group; whereas group II and III were ceftriaxone and sulbactomax treated groups. Drugs were analyzed in CSF by high performance liquid chromatography. Some biochemical parameters were studied in infected and treated groups. Present results showed that the mean level of ceftriaxone drug concentration was increased significantly in sulbactomax treated group in comparison to ceftriaxone alone treated group. Glucose level was increased in sulbactomax treated group as compared to ceftriaxone alone treated group. The levels of protein, calcium and phosphorus were significantly lowered in both treated group as compared to infected group. These biochemical parameters were decreased along with increased glucose level in sulbactomax treated group in comparison to ceftriaxone alone treated group. Present findings concluded that sulbactomax enhanced the penetration rate in CSF than ceftriaxone alone due to VRP1034. It plays a therapeutic role in crossing blood brain barrier and helps in prevention of bacterial meningitis infection.
  M.R. Siddiqui , A. Tariq , K.D. Reddy , P.S. Negi , J. Yadav , A. Bhatnagar , M. Chaudhary and R. Singh
  A simple and sensitive assay method was developed for simultaneous determination of cefepime and sulbactam sodium in Supime (a fixed dose combined formulation of cefepime and sulbactam manufactured by Venus Remedies limited, India) with UV detection at 230 nm. Chromatographic separation of two drugs was achieved on a Hypersil ODS C-18 column using a binary mixture of acetonitrile and tetrabutyl ammonium hydroxide as a mobile phase adjusted to pH 5.0 with orthophosphoric acid in ratio 20:80 v/v ratio. The developed liquid chromatographic method offers good linearity, accuracy and precision over the concentration range of 125-750 ppm for cefepime and 62.5-375 ppm for sulbactam sodium. This method was successfully applied for the quality control of formulated products and plasma samples containing Cefepime and sulbactam. Since, Supime, a fixed dose combination of cefepime and sulbactam is a research product of Venus Remedies limited the literature lacks any method of analysis for such combination, the main motive behind this experiment was to develop and validate a method which could be used for the quality control of cefepime and sulbactam in combined dosage form.
  P. Kaushik , D. Kaushik , J. Yadav and P. Pahwa
  The activity of the alcoholic extract of the rhizomes of Alpinia galanga was studied for the treatment of diabetes-induced nephropathy in rats. Wistar rats received a single intraperitoneal streptozotocin injection (60 mg kg-1 b.wt.) to induce diabetes. Rats were considered diabetic if blood glucose concentration increased up to 200 or more mg dL-1. The rats were orally administered alcoholic extract of Alpinia galanga (50, 100 and 200 mg kg-1), once daily for 40 days. Body weight, blood glucose, urinary albumin, glycosylated haemoglobin, Blood Urea Nitrogen (BUN), creatinine, lipids profile, Malondialdehyde (MDA), Superoxide Dismutase (SOD), Glutathione (GSH) and Catalase (CAT) were then evaluated. After 40 days of treatment, Alpinia galanga significantly (p<0.05) decreased glycaemia, Blood Urea Nitrogen (BUN), urinar albumin and increased body weight in diabetes-nephropathic rats. The extract (200 mg kg-1) decreased MDA significantly (p<0.01); GSH (p<0.05), increased SOD (p<0.05) and CAT (p<0.05) in the rats, compared with nephropathic control. The extract (100 and 200 mg kg-1, respectively) lowered (p<0.05) total cholesterolemia, blood triglycerides (p<0.05), blood LDL cholesterol (p<0.05), but increased blood HDL cholesterol (p<0.01). Overall, atherogenic index was decreased significantly (p<0.05). In the present study, the rhizomes of Alpinia galanga demonstrated significant nephro-protective activities in the tested models. The alcoholic extract of the rhizomes of Alpinia galanga holds promise for the development of a standardized phytomedicine for diabetes mellitus and kidney disease treatment.
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