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Articles by J. Xie
Total Records ( 3 ) for J. Xie
  H. Zhu , X. Zhang , M.-Z. Li , J. Xie and X.-L. Yang
 

Aims

To determine the prevalence of Type 2 diabetes and pre-diabetes and their risk factors among overweight or obese school children aged 7-18 years in Tianjin, China.

Methods

A cross-sectional survey in a representative sample of overweight/obese children or adolescents in Tianjin was conducted from May to August 2010 using a stratified cluster sampling method. A two-step screening, which was conducted to identify Type 2 diabetes and pre-diabetes in these children, consisted of a fasting capillary glucose test and a standard 2-h oral glucose tolerance test. Subjects who had fasting capillary glucose ≥ 5.6 mmol/l were invited for an oral glucose tolerance test. The study used Chinese criteria for classification of obesity/overweight and World Health Organization criteria for diabetes/pre-diabetes.

Results

A total of 3173 children participated in the survey, with a response rate of 99.0%. Of the children, 13.0% (n = 413) were overweight and 15.4% (n = 490) were obese. Among these 903 children, 727 (80.5%) agreed to and underwent the diabetes screening and two (0.28%) were diagnosed as having Type 2 diabetes, six (0.83%) to have impaired fasting glucose, 16 (2.20%) to have impaired glucose tolerance and two (0.28%) to have both. The prevalence of Type 2 diabetes and pre-diabetes was 0.28% (95% CI 0.08-1.00%) and 3.30% (95% CI 2.23-4.87%), respectively. Abdominal obesity and motorized commuting were associated with Type 2 diabetes or pre-diabetes among overweight or obese boys, while high birthweight was associated with Type 2 diabetes or pre-diabetes among girls.

Conclusions

Type 2 diabetes among school-aged children was still low in Tianjin, China. However, Type 2 diabetes-related factors were very common, especially overweight and obesity.

  J. Xie , N. Imanishi , T. Zhang , A. Hirano , Y. Takeda and O. Yamamoto
 

LiCoPO4 thin films were deposited on Li1+x+yAlxTi2-xSiyP3-yO12 (LATSP) solid electrolyte by radio frequency magnetron sputtering and were characterized by X-ray diffraction and scanning electron microscope. The films show a (1 1 1) preferred orientation upon annealing and are chemically stable with LATSP up to 600 °C in air. An all-solid-state Li/PEO18-Li(CF3SO2)2N/LATSP/LiCoPO4/Au cell was fabricated to investigate the electrochemical performance and Li-ion chemical diffusion coefficients, , of the LiCoPO4 thin films. The potential dependence of values of the LiCoPO4 thin film was investigated by potentiostatic intermittent titration technique and was compared with those of the LiFePO4 thin film. These results showed that the intercalation mechanism of Li-ion in LiCoPO4 is different from that in LiFePO4.

  H Li , G Liu , J Yu , W Cao , V. G Lobo and J. Xie
 

Alternative pre-mRNA splicing is often controlled by cell signals, for example, those activating the cAMP-dependent protein kinase (PKA) or the Ca2+/calmodulin-dependent protein kinase IV (CaMKIV). We have shown that CaMKIV regulates alternative splicing through short CA repeats and hnRNP L. Here we use a splicing reporter that shows PKA/CaMKIV promotion of exon inclusion to select from exons containing random 13-nt sequences for RNA elements responsive to the kinases in cultured cells. This selection not only identified both PKA- and CaMKIV-responsive elements that are similar to the CaMKIV-responsive RNA element 1 (CaRRE1) or CA repeats, but also A-rich elements not previously known to respond to these kinases. Consistently, hnRNP L is identified as a factor binding the CA-rich elements. Analyses of the motifs in the highly responsive elements indicate that they are indeed critical for the kinase effect and are enriched in alternative exons. Interestingly, a CAAAAAA motif is sufficient for the PKA/CaMKIV-regulated splicing of the exon 16 of the CaMK kinase β1 (CaMKK2) transcripts, implying a role of this motif in signaling cross-talk or feedback regulation between these kinases through alternative splicing. Therefore, these experiments identified a group of RNA elements responsive to PKA and CaMKIV from in vivo selection. This also provides an approach for selecting RNA elements similarly responsive to other cell signals controlling alternative splicing.

 
 
 
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