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Articles by J. Vejayan
Total Records ( 3 ) for J. Vejayan
  M.E.S. Mirghani , F. Yosuf , N.A. kabbashi , J. Vejayan and Z.B.M . Yosuf
  This study is emphasized specifically on the potential of the mango Mangifera Indica seed kernel by discovering the prospective usage of mango seed kernels as a source of antibacterial compounds against Gram-positive (Staphylococcus aureus and Bacillus subtilis) and Gram-negative (Escherichia coli and Pseudomonas aeruginosa) bacterial strains. For this study, three types of mango were used; Blackgold, Lemak and Waterlily from Malaysia and Thiland. The approach adopted for this purpose was by implementing agar well diffusion method. The results were expressed as the average diameter of bacterial inhibition zones surrounding the wells. The required solvents for the extraction were ethanol, methanol, acetone and phosphate buffer solutions were prepared in a different concentration; 0.10M, 0.05M and 0.01M. The results showed that Lemak gave relatively high antibacterial activity among other types of mango ranging between 1.40 and 2.23 cm. For the known antibiotic, which was Tetracycline, under the same conditions the diameter of inhibition zones were between 2.30 to 3.30. Then, the minimum inhibition concentration tests were conducted for Lemak for two solvents extract that gave the highest inhibition zones which were methanol and acetone. The results showed that the minimum inhibition concentration of extracts that inhibited the growth of Escherichia coli and Bacillus subtilis was after 10X dilution (1 mM). The results obtained confirmed the antibacterial potential of mango kernels extracts and this would probably become an alternative source of new and natural antibacterial agents.
  T.M. San , J. Vejayan , K. Shanmugan and H. Ibrahim
  The study was carried out to screen antimicrobial activity in venoms obtained from 11 species of snakes that are all common in Malaysia. Snake venom, which constitutes a diverse range of proteins, has long been identified as a potential source of therapeutics. Therefore, in times when antimicrobial resistance is becoming an increasingly severe issue, it is unsurprising that snake venoms are being investigated for antimicrobial components. Antibacterial activity was assessed using the hole-plate method. Venoms of Calloselasma rhodostoma and Ophiophagus hannah were capable of producing the most prominent bacterial inhibition zones with maximum values as high as 12 mm, while the other venoms screened only produced bacterial inhibition zones that were not more than 10 mm. These two venoms were selected for further determination of Minimum Inhibitory Concentration (MIC). The MIC values were tested with Staphylococcus aureus ATCC25923, ATCC29213 and ATCC43300. The MIC values obtained for Calloselasma rhodostoma were 125 μg mL-1 when tested against S. aureus ATCC25923 and ATCC43300, while it was 250 μg mL-1 when tested against S. aureus ATCC29213. MIC values obtained for Ophiophagus hannah were 250 μg mL-1 when tested against all three strains. Since the potential of snake venoms for antimicrobial activity has been established, further study is in the progress to purify the active antimicrobial component and to screen a wider range of bacterial strains.
  J. Vejayan , A. Jamunaa , I. Halijah and S. Ambu
  Background and Objective: Mimosa pudica has been used for many traditional healings including snake bites, wound healing, treating bleeding piles, ulcers, diarrhea, anti-inflammatory, anti-diabetic, anti-oxidant and anti-microbial etc. Tannin extracted from plants been beneficial as therapeutics with dividing opinions on its safety. Hence, this study investigated the safety of the total tannin extracted from the root of Mimosa pudica plant. Methodology: This investigation utilized biochemical markers as well as cytotoxicity and histopatological experiments. Additionally, the total condensed and hydrolysable tannins determined in the particular root extract of the Mimosa pudica plant. Results: Extract of MPT at the highest dose tested 2.5 mg mL–1 elevated significantly the levels of mice serum contained ALT and AST while no observable changes to ALP and GGT levels detected. The cytotoxicity of MPT was found to be with CTC50 values of 0.0653 and 0.119 mg mL–1 in vero and MDCK cell lines, respectively. The mice organ’s histopathology of liver and kidney demonstrated MPT having distinct toxic effects at the highest concentration tested. The total tannin in MPT found to be 3.28 mg TAE g–1 dry weight with more hydrolysable type of tannin than condensed tannin 0.31 TAE/dry weight. Conclusion: The MPT found to show adverse effects in all experiments conducted at the highest concentration of 2.5 mg mL–1. Hence, the age old doubt regarding the adverse effects of tannin being proven here whereby it was discovered the use of Mimosa pudica total tannin is concentration dependent. Therefore, warranted prior caution in determining the safe levels of tannin required before usage.
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