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Articles by J. Sakamoto
Total Records ( 2 ) for J. Sakamoto
  T Yoshikawa , A Tsuburaya , S Morita , Y Kodera , S Ito , H Cho , Y Miyashita and J. Sakamoto

This randomized Phase II trial compares neoadjuvant chemotherapy of two or four courses of S-1 (1 M tegafur–0.4 M gimestat–1 M ostat potassium) plus cisplatin or paclitaxel plus cisplatin by a two-by-two factorial design for patients with macroscopically resectable locally advanced gastric cancer. The primary endpoint is the 3-year overall survival. The sample size is 60–80 in a total for two hypotheses of the superiority of four courses to two courses and the superiority of paclitaxel plus cisplatin to S-1 plus cisplatin. In both arms, S-1 is strongly recommended post-operatively for at least 6 months but no adjuvant chemotherapy is permitted other than S-1 until recurrence. This trial could appraise more suitable cycles and regimen as neoadjuvant chemotherapy for gastric cancer.

  Y Kabashima , J. i Kishikawa , T Kurokawa and J. Sakamoto

Corynebacterium glutamicum contains at least two terminal oxidases in the respiratory chain; cytochrome aa3-type cytochrome c oxidase and bd-type menaquinol oxidase. Thus, the chain has two branches of electron flow. The bcc-aa3 branch translocates three protons per electron transferred, while the bd branch translocates only one. In this study, we constructed two mutant strains, lacking of either subunit I of the cytochrome c oxidase (ctaD) or subunits I and II of the quinol oxidase (cydAB), and also plasmids to complement the deficient genes to investigate their effects on energy conservation and cell growth. We measured H+/O ratios of C. glutamicum wild-type and mutant cells grown aerobically. The H+/O ratio of the wild-type cells grown in the semi-synthetic medium was 3.94 ± 0.30, while the value was 2.76 ± 0.25 for the ctaD mutant. In contrast, the value was 5.23 ± 0.36 for the cydAB mutant. The cells grown in the LB medium showed higher value compared to that of cells grown in the semi-synthetic medium. The ctaD mutant grew less than the wild-type in LB medium, while they grew about equally in semi-synthetic medium. Correlation between bioenergetics and growth of C. glutamicum was significantly affected by the growth nutrients.

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