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Articles by J. Lin
Total Records ( 3 ) for J. Lin
  W Li , C Wang , S. K Juhn , F. G Ondrey and J. Lin

Objectives  To characterize the expression of fibroblast growth factor binding protein (FGF-BP) messenger RNA (mRNA) in head and neck squamous cell carcinoma (HNSCC) and to study the association of FGF-BP with vascularity.

Design  The expression of FGF-BP mRNA in HNSCC was studied in 35 primary and 8 metastatic HNSCC specimens and 7 control tissues using in situ hybridization and reverse transcriptase–polymerase chain reaction (RT-PCR). Microvessels in tumor specimens were identified with endothelial cell markers (von Willebrand factor [vWF] and CD34-specific antibodies). Correlates between FGF-BP and microvessel counts were evaluated statistically.

Setting  University of Minnesota Hospitals and Clinics.

Patients  Forty-two surgically treated patients with HNSCC.

Interventions  The patients were routinely treated in the study hospitals and clinics.

Main Outcome Measures  The expression of FGF-BP and angiogenesis in tumors were evaluated.

Results  In situ hybridization and RT-PCR demonstrated that FGF-BP mRNA transcripts were expressed in 34 of 35 primary HNSCC specimens and 5 of 8 metastatic tumor specimens but not in adjacent control tissues. The microvessel counts in HNSCC specimens were closely related to the expression level of FGF-BP (P < .001).

Conclusion  The expression of FGF-BP is statistically linked to the angiogenesis of HNSCC, suggesting that FGF-BP participates in the angiogenesis of HNSCC.

  T.H. Zhang , J. Lin , C.G. Liu , R.G. Ding , J.X. Ruan , X.H. Sun , C.Q. Huang and X.C. Zhang
  The aim of this study was to elucidate whether changes of surface activity of cholic acid analogs may lead to alteration of its pharmacological potency. The potencies of various cholic acid analogs were explored by two mice models, Perfluoroisobutylene induced pulmonary edema and Xylene induced ear edema. Determination of the Critical Micelle Concentration (CMC), an index for the comparison of the surface activity, of cholic acid analogs was also conducted. The results showed that administration of cholic acid analogs decreased the water content in the organ with a potency of chendehydroxycholic acid > dehydroxycholic acid > ursodehydroxycholic acid > hyodehydroxycholic acid > cholic acid. This is in accordance with the sequence of CMC. We suggest, that the effects of cholic acid analogs might be closely related with their surface activity.
  J. Lin , Z.L. Wu , X.H. Zhang , B. Mishra , J.J. Moore and W.D. Sproul
  Chromium nitride (CrNx) coatings were prepared by reactively sputtering chromium metal target with various nitrogen flow rate percentages (fN2) using a closed field unbalanced magnetron sputtering system operated in dc and middle frequency pulsed condition (100 kHz and 50% duty cycle). In this study, plasma examination proved that a large amount of ions with a wide range of ion energies (up to 65 eV and mainly from 10–30 eV region) was identified in the pulsed plasma compared to the low ion flux and energy (0–10 eV) in a dc discharged plasma. The results showed that the phase structure of CrNx coatings was changed from nitrogen doped Cr(N) to pure β-Cr2N, and to a mixture of β-Cr2N and c-CrN and then to pure c-CrN phases with an increase in the fN2 in both dc and pulsed conditions. However, the pulsed CrNx coatings exhibit lower N concentrations than dc CrNx coatings prepared under the same fN2, which leads to the existing of β-Cr2N phase within a wide range of fN2 (30–50%). In comparison with the typical large columnar structure in the dc sputtered coatings, the pulsed CrNx coatings exhibit dramatic microstructure improvements which benefited from the improved plasma density and ion bombardment from the pulsed plasma, where the super dense and nearly equi-axial structures were observed in a wide range of fN2. The microstructure improvements contributed to the enhancements in the hardness and wear resistance of pulsed CrNx coatings. In the pulsed CrNx coatings, the hardness values were above 30 GPa when the fN2 is in the range of 30–40%, which is related to the formation of the β-Cr2N phase. With the formation of a mixture of β-Cr2N and c-CrN phases in the coatings deposited with 40–50% fN2, a low COF of 0.36 and wear rate of 1.66 × 10− 6 mm3 N− 1 m− 1 can be achieved.
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