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Articles by J. Lazar
Total Records ( 2 ) for J. Lazar
  H Kamran , L Salciccioli , Eun Hee Ko , H Kazmi , J Kassotis and J. Lazar
 

This pilot study assessed the effects of hyperemia on carotid-radial pulse wave velocity (PWV) in 39 normotensive (NT) and 23 hypertensive (HT) participants using applanation tonometry. Pulse wave velocity was measured at 1- and at 2-minute intervals. Baseline PWV was similar between the groups (P = .59). At 1 minute, PWV decreased (8.5 ± 1.2 to 7.1 ± 1.4 m/s, P < .001) in NT but not in HT (P = .83). Hyperemic PWV (PWV) response differed between the groups (-16% vs + 1.0%, P < .001). On multivariate analysis, HT, not age or blood pressure was independently related to PWV (R2 = .43, P < .01). Among patients with cardiovascular risk factors/disease, PWV was inversely related to flow-mediated dilation (FMD; R 2 = .43, P < .003). Conclusion: hyperemia decreases PWV1min in NT but not in HT. PWV is inversely related to FMD. Blunted hyperemic PWV response may represent impaired vasodilatory reserve.

  H Kamran , L Salciccioli , B Venkatesan , V Namana , P Kumar , S Pushilin , M Umer and J. Lazar
 

Carotid—radial pulse wave velocity (PWV) decreases in normal healthy individuals following hyperemia provoked by release of arterial cuff occlusion. To determine the effects of specific cardiovascular (CV) risk factors on the hyperemic PWV response, we measured PWV before and after brachial artery (BA) occlusion in 218 participants (66% males, age 56 ± 19 years), with and without CV risk factors/disease. PWV ranged from -46% to +35% and values were normally distributed. On univariate analyses, PWV correlated with age, hypertension (Htn), hypercholesterolemia, diabetes mellitus (DM), coronary disease, congestive heart failure (CHF), smoking, and mean arterial pressure (MAP). On multivariate analysis, PWV was independently related to Htn (B = 4.56, P = .03) and CHF (B = 7.34, P = .008) and trended toward a higher MAP (B = .113, P = .067), DM (B = 4.01, P = .11), and hypercholesterolemia (B = 3.36, P = .12). In conclusion, hyperemic changes in carotid—radial PWV values are independently related to Htn and CHF and possibly DM and hyperlipidemia.

 
 
 
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