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by
J. Kim |
Total Records (
7 ) for
J. Kim |
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J Li
and
J. Kim
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Our inability to distinguish between low-grade prostate cancers that pose no threat and those that can kill compels newly diagnosed early prostate cancer patients to make decisions that may negatively affect their lives needlessly for years afterward. To reliably stratify patients into different risk categories and apply appropriate treatment, we need a better molecular understanding of prostate cancer progression. Androgen ablation therapy and 5- reductase inhibitors reduce dihydrotestosterone levels and increase apoptosis. Because of the differing biological potentials of tumor cells, however, these treatments may, in some cases, worsen outcome by selecting for or inducing adaptation of stronger androgen receptor signaling pathways. Reduced dihydrotestosterone also may be associated with altered survival pathways. Complicating treatment effects further, molecular adaptation may be accelerated by interactions between epithelial and stromal cells. The hypothesis that early prostate cancer cells with differing biological potential may respond differently to finasteride treatment is worth testing. Ongoing studies using a systems biology approach in a preoperative prostate cancer setting are testing this hypothesis toward developing more-rational clinical interventions. |
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M.A. Mastro
,
S. Maximenko
,
M. Gowda
,
B.S. Simpkins
,
P.E. Pehrsson
,
J.P. Long
,
A.J. Makinen
,
J.A. Freitas Jr.
,
J.K. Hite
,
C.R. Eddy Jr.
and
J. Kim
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Photo- and cathodo-luminescence measurements of a variable-diameter ensemble of GaN nanowires revealed a diameter-dependent, spectral emission distribution between 350 nm and 850 nm. Spectral analysis indicated that wires with a diameter less than 400 nm were dominated by a yellow luminescence with a weaker near UV/violet emission also present. Examination of this ensemble showed that there was a general trend in the ratio of near-UV-to-yellow emission intensities with increasing nanowire diameter. Additionally, a broad green emission appears in the nanowires with a diameter above approximately 200& nm. A calculation based on the nanoheteroepitaxy model indicates that this diameter represents a transitional thickness where strain is relieved by defect formation mechanisms with a characteristic green emission. |
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J. Kim
,
J. Lee
and
S. Kang
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The military is devoting efforts toward the development of evaluation information systems for the
logistics performance management. Nevertheless, it is difficult to understand the factors affecting the
performance management and its improvement. In this study, we suggest that the DEA-ANP provides a
supplementary measure for the performance evaluation of a military supply support system. The DEA Model
that measure efficiency from the input/output perspective and the ANP Model that complements the
discriminant power can facilitate the measurement of the efficiency of the military supply support system as well
as the benchmarking of superior teams. |
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Y. Han
,
J. Kim
,
H. Jang
,
H. Sohn
and
K. Yoo
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Cities are now experiencing accidents with unpredicted ground collapses adjacent to the existing
properties. Such ground collapses, caused by natural or artificial factors, may harm the assets in dense urban
areas. This study discusses the ground collapse induced by groundwater level disturbance in an excavation
site. The subsurface condition was characterized by geophysical methods; ground loosening region around
the excavation site was detected and analyzed by Real Time Kinematic (RTK), Ground Penetrating Radar (GPR)
and Electrical Resistivity Tomography (ERT). To overcome the unreliability or ambiguity problems in the
interpretation results, interpretations of the ERT and GPR data are compared and then, integrated for detection
of the water leakage in this case study. The survey results showed a wide range of adjacent ground was
loosened due to groundwater drawdown. A numerical analysis in MODFLOW was carried out to simulate the
groundwater flow on the site. Finally, it can be concluded that the soil erosion due to water leakage and the
positive groundwater discharge was the main contributing factor of the collapses. The initial ground
improvement plan of high pressure grouting, therefore had to be replaced by low pressure grouting to avoid
any further soil erosion that would eventually lead to potential collapses on the adjacent site. |
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D Siskind
,
R Araya
and
J. Kim
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Background
Low- and middle-income countries lack information on contextualised mental
health interventions to aid resource allocation decisions regarding
healthcare.
Aims
To undertake a cost-effectiveness analysis of treatments for depression
contextualised to Chile.
Methods
Using data from studies in Chile, we developed a computer-based Markov
cohort model of depression among Chilean women to evaluate the
cost-effectiveness of usual care or improved stepped care.
Results
The incremental cost-effectiveness ratio (ICER) of usual care was I$113 per
quality-adjusted life-year (QALY) gained, versus no treatment, whereas stepped
care had an ICER of I$468 per QALY versus usual care. This compared favourably
with Chile’s per-capita GDP. Results were most sensitive to variation in
recurrent episode coverage, marginally sensitive to cost of treatment, and
insensitive to changes in health-state utility of depression and rate of
recurrence.
Conclusions
Our results suggest that treatments for depression in low- and
middle-income countries may be more cost-effective than previously
estimated. |
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K.S. Kang
,
Y. Chen
,
K.J. Han
,
K.H. Yoo
and
J. Kim
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Polymer conductivity is key factor to improve the performance of the electronic and photonic devices. Poly(3,4-ethylenedioxythiophene):poly(4-styrenesulfonate) (PEDOT:PSS) films were soaked into 0.03, 0.14, 0.41, and 1.13 M concentrations of HCl–methanol solution for 10, 20, 30, 40, 50, 60, and 70 min. The resulting films were investigated using Fourier transform infrared (FTIR) spectrometry, conductivity measurements, and field emission scanning electron microscopy. The characteristic FTIR absorption peaks of poly(4-styrenesulfonate) (PSS) of the films decreased as the soaking time increased. While PSS absorption peaks appeared in the HCl–methanol soaking solution and increased with the soaking time. The conductivity of PEDOT:PSS film was approximately 1.20 × 10− 6 S/cm before soaking in the HCl–methanol solution. The conductivity of PEDOT:PSS was enhanced nearly three orders of magnitude after soaking the films into the HCl–methanol solvent. The surface of PEDOT:PSS film was initially very smooth. However, numerous humps appeared on the surface of the films after soaking PEDOT:PSS film into the HCl–methanol solution for 10, 20, and 30 min. The number of humps was reduced and disappeared thereafter. |
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K.S. Suh
,
N.J. Yi
,
J. Kim
,
W.Y. Shin
,
H.W. Lee
,
H.S. Han
and
K.U. Lee
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Background: We performed a modified right hepatectomy completely by laparoscopic techniques preserving the middle hepatic vein (MHV) branches in adult-to-adult living donor liver transplantation (LDLT). Patients and Methods: Two young women (24 and 25 years old) volunteered to be live donors for their parents who had hepatocellular carcinomas. As the donors expressed concerns about scarring, we performed a laparoscopic procedure using a hand port device. Mobilization of the right liver and the hepatic parenchymal transection were performed under pneumoperitoneum. Parenchymal transection was performed using a laparoscopic ultrasonic aspirator without the Pringle maneuver. During parenchymal transection, major MHV branches >5 mm were preserved using Hem-o-lock clips. The graft was extracted through the hand port site. On the back table, the 3 MHV branches were reconstructed using an artificial vascular graft. The livers were transplanted without complications.Results: The operative times for the donors were 765 and 898 minutes. The donors did not require transfusions or reoperation; they were discharged on postoperative days 10 and 14 with normal liver functions.Conclusion: A hepatectomy performed completely by laparoscopic techniques for a right graft with preservation of the MHV branches was technically feasible. |
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