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Articles by J. Hu
Total Records ( 3 ) for J. Hu
  L. Chen , Q. Li , Z. Yang , Z. Ye , Y. Huang , M. He , J. Wen , X. Wang , B. Lu , J. Hu , C. Liu , C. Ling , S. Qu and R. Hu
  Aim  To assess the relationship between serum total osteocalcin and measurements of adiposity, glucose tolerance, lipid profile, adipokine and chronic low-grade inflammation in middle-aged and elderly Chinese subjects.

Methods  We performed a cross-sectional community-based study in central Shanghai. Serum total osteocalcin was measured by radioimmunoassay in 783 men and 946 post-menopausal women. Their associations with measurements of adiposity, glucose tolerance, lipid profile and chronic low-grade inflammation were examined.

Results  Serum total osteocalcin levels revealed a sexual dimorphism, with post-menopausal women having significantly higher levels than men (< 0.001). Serum osteocalcin levels of participants with self-reported cardiovascular disease were significantly lower (= 0.044) than those without. In men, serum osteocalcin levels of participants with the metabolic syndrome were significantly lower than those without the metabolic syndrome (= 0.036). Serum osteocalcin correlated negatively with fasting serum insulin, homeostasis model assessment of insulin resistance, alanine aminotransferase, triglycerides and total cholesterol, and positively with homeostasis model assessment of β-cell function in both men and post-menopausal women (all < 0.05). In men, serum osteocalcin correlated negatively with BMI, diastolic blood pressure, fasting plasma glucose and 2-h oral glucose tolerance test glucose after adjustment for age (all < 0.05). In post-menopausal women, serum osteocalcin correlated negatively with waist-hip ratio, LDL cholesterol and C-reactive protein, and positively with adiponectin (all < 0.05). Serum osteocalcin was not associated with CXC chemokine ligand 5 level (> 0.05). Alanine aminotransferase was an independent predictor of serum osteocalcin in both men and post-menopausal women (both < 0.001). Adiponectin was an independent predictor of serum osteocalcin in post-menopausal women (= 0.011). Serum osteocalcin was an independent predictor of homeostasis model assessment of β-cell function in both genders (both < 0.05).

Conclusions

  L. Zhang , Y. Luo , J. Hu , J. Wang , X. Liu and H. Pan
  CAPNS1 also known as CAPN4, encodes the small subunit of CAPN1 and CAPN2 which is required to maintain stability and activity of both calpains. But to date polymorphism of yak CAPNS1 has not been reported. In this study, variation in the exon 6-intron 6 region of CAPNS1 was investigated in 1059 yaks and Chinese cattle by Polymerase Chain Reaction-Single Strand Conrmational Polymorphism (PCR-SSCP). Five PCR-SSCP patterns representing five allelic variations and containing four Single Nucleotide Polymorphisms (SNPs) in intron 6 were observed. Allele B was the most common allele with a frequency of 48.12% in yak and 93.29% in Chinese cattle whereas allele A and C were only in yak as well as allele D and E were rare (0.42 and 0.16%, respectively) and only in Chinese cattle. These results indicate that yak and cattle CAPNS1 is polymorphic and suggest further analysis is required to see if the variation detected affects their meat quality.
  J. Hu , G.H. Parker and M.A. Persinger
  The aim of the study was to discern if Sudden Infant Death Syndrome (SIDS) reflects a transient vulnerability to stimuli during anomalous ontogeny of normal cellular interaction within brain stem structures such as the parasolitary (Psol) nucleus. Perinatal exposure equivalent to the strength and frequency of a magnetic field configuration correlated with SIDS was utilized to produce alterations in cellular asymmetry within the Psol nucleus. The numbers of neurons and nuclei of astroglia and oligodendroglia from n = 40, 5 and 15 day old rats that had been exposed to a 0.5 Hz, 5 to 10 nT magnetic field between -3 to +7 days of birth and were counted at 1000 X. A robust and significant interaction (explaining 30% of the variance) between numbers of astroglia nuclei in the right vs. the left side of the nucleus, age and exposure to the field was demonstrated. These results indicate exposure to this specific intensity and frequency may delay the normal ontogeny of asymmetry-to-symmetry in cell numbers that affect the blood brain barrier and neuronal function. Greater attention to neuroaxial asymmetry in post-mortem measures of SIDS cases may be warranted.
 
 
 
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