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Articles by J. Gunaseelan
Total Records ( 1 ) for J. Gunaseelan
  R. Neha , Vahitha Vali , J. Gunaseelan and K. Perinbam
  An investigation on the antioxidant and antiproliferative activities of Nigella sativa seeds was carried out. The methanolic extract from the dried sample of Nigella sativa seeds was prepared and examined for its phytochemical composition. The sample exhibited noticeable scavenging effects in DPPH free radical scavenging assay. It has also been evaluated the effect of methanolic extract of Nigella sativa seed on HepG2, MCF-7 and VERO cells proliferation using the MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide) assay. After 72 h incubation, HepG2 and MCF-7 cell proliferation was inhibited upto 50% by the methanolic extract. The phytochemical constituent appears to be responsible at least in part, for the observed antioxidant activity of the methanolic extract. The greater reducing activity of the extract reflected the generally greater phenolic content of the Nigella sativa. The DNA fragmenting pattern of the Nigella sativa seed extract was identified using DNA fragmentation assay. The number of DNA fragments were increased with the concentration of the seed extract. The results suggest that the Nigella sativa seeds could be a potential source of natural antioxidant.
 
 
 
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