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Articles by J. Feng
Total Records ( 8 ) for J. Feng
  J Xiao , S Yin , Y Li , S Xie , D Nie , L Ma , X Wang , Y Wu and J. Feng

S-phase kinase-associated protein 2 (SKP2) gene is a tumor suppressor gene, and is involved in the ubiquitin-mediated degradation of P27kip1. SKP2 and P27kip1 affect the proceeding and prognosis of leukemia through regulating the proliferation, apoptosis and differentiation of leukemia cells. In this study, we explored the mechanism of reversing of HL-60/A drug resistance through SKP2 down-regulation. HL-60/A cells were nucleofected by Amaxa Nucleofector System with SKP2 siRNA. The gene and protein expression levels of Skp2, P27kip1, and multi-drug resistance associated protein (MRP) were determined by reverse transcription-polymerase chain reaction and western blot analysis, respectively. The cell cycle was analyzed by flow cytometry. The 50% inhibitory concentration value was calculated using cytotoxic analysis according to the death rate of these two kinds of cells under different concentrations of chemotherapeutics to compare the sensitivity of the cells. HL-60/A cells showed multi-drug resistance phenotype characteristic by cross-resistance to adriamycin, daunorubicin, and arabinosylcytosine, due to the expression of MRP. We found that the expression of SKP2 was higher in HL-60/A cells than in HL-60 cells, but the expression of P27kip1 was lower. The expression of SKP2 in HL-60/A cells nucleofected by SKP2 siRNA was down-regulated whereas the protein level of P27kip1 was up-regulated. Compared with the MRP expression level in the control group (nucleofected by control siRNA), the mRNA and protein expression levels of MRP in HL-60/A cells nucleofected by SKP2 siRNA were lower, and the latter cells were more sensitive to adriamycin, daunorubicin, and arabinosylcytosine. Down-regulating the SKP2 expression and arresting cells in the G0/G1 phase improve drug sensitivity of leukemia cells with down-regulated MRP expression.

  H.B. Tang , B.G. Xu , X.M. Tao and J. Feng
  In the paper, yarn dynamical behavior and twist distribution in a modified ring spinning system are investigated. Equations of motion and twist wave propagation are used to obtain the numerical solutions of yarn path, yarn tension and twist distribution in steady state. It is observed that yarn path in the twisting zone has several classic modes corresponding to the yarn tension, and all of the yarn paths are approximately planar curves rather than spatial curves. The angular velocities of yarn at the twisting device are given as well as the twist of yarn in the modified ring spinning system. Experiments are conducted to evaluate the yarn paths and twist distributions under consideration. The theoretical and experimental results have a good agreement.
  S. F. Ehrlich , M. M. Hedderson , C. P. Quesenberry Jr , J. Feng , S. D. Brown , Y. Crites and A. Ferrara


Women with gestational diabetes are at high risk for developing diabetes; post-partum weight loss may reduce the risk of diabetes. We evaluated the association of post-partum weight change with changes in glucose, insulin and homeostasis model assessment of insulin resistance in a subsample (n = 72) of participants from Diet Exercise and Breastfeeding Intervention (DEBI), a randomized pilot trial of lifestyle intervention for women with gestational diabetes.


Glucose and insulin were measured fasting and 2 h after an oral glucose tolerance test at 6 weeks and 12 months post-partum. Women were categorized by weight change (lost > 2 kg vs. maintained/gained) between 6 weeks and 12 months post-partum.


Compared with women who maintained or gained weight, women who lost > 2 kg experienced significantly lower increases in fasting glucose [age-adjusted means: 0.1 mmol/l (95% CI -0.03 to 0.3) vs. 0.4 mmol/l (95% CI 0.3-0.6); < 0.01] and 2-h insulin [10.0 pmol/l (95% CI -56.9 to 76.9) vs. 181.2 pmol/l (95% CI 108.3-506.9); < 0.01] and a significant reduction in 2-h glucose [-0.9 mmol/l (95% CI -1.4 to -0.3) vs. 0.3 mmol/l (95% CI -0.3 to 0.9); < 0.01]. In multiple linear regression models adjusted for age, Hispanic ethnicity, medication use, meeting the Institute of Medicine's recommendations for gestational weight gain, breastfeeding and randomized group, a 1-kg increase in weight was significantly associated with increases in fasting and 2-h glucose (P < 0.05), but was not associated with insulin or homeostasis model assessment of insulin resistance.


In women with gestational diabetes, modest post-partum weight loss may be associated with improvements in glucose metabolism.

  W.X. Tian , N. Sun , G.B. Ning , D.J. Zhang , J. Feng , T.X. Lv , Y. Wang , H.M. Wang , X.H. Wang and F. Li
  This study was designed to investigate the influence of Gallid herpesvirus 2 Marek's Disease challenge virus and different inoculated routes of attenuated vaccine virus CVI988/Rispens on immune adhesion of erythrocytes in chickens. One day old chicks were randomly divided into a control group (C), an experimental group challenged with Jing-1 challenge strain (V), a second and third experimental group individually injected intra-abdominally (IA) or subcutaneously (SC) with vaccine strain, CVI988/Rispens. The erythrocyte immune adhesion was evaluated with yeast rosette-forming tests of red blood cell complement receptor type 1 (RBC-CR1) and red blood cell immune complex (RBC-IC). It was found that chickens from group V had fewer erythrocytes. During this time, the rate of RBC-IC rosette formation was higher in group V except on days 3 and 20. While the rate of RBC-CR1 rosette formation was lower in group V except on the 26th day when the number of RBC-CR1 rosettes was extremely higher. The rate of RBC-CR1 rosette formation and RBCs count was higher in group IA than that of SC. The results suggest that challenge virus lead to immune suppression, a decline in the immune adhesion of RBCs followed by a rebound during the later stages of infection; effects on RBC immunity were increased after inoculate attenuated vaccines strains; IA vaccination route may enhance the immune adhesion of RBCs comparing with SC route; and an improvement in the RBC immunity adhesion during the later stages of infection may have resulted from a compensatory immune response to immune organ atrophy and the decrease of RBCs.
  L Xu , C He , C Shen , T Jiang , L Shi , K Sun , S. W Berquist and J. Feng

The geographical patterns of the genetic structure of Hipposideros armiger in China were assessed by analyzing sequence variation in the mitochondrial DNA control region. Analysis of molecular variance revealed a very strong genetic structure among 5 regions in H. armiger. A neighbor-joining tree, haplotype network construction by TCS and multidimensional scaling plots all showed significant geographic differentiation among 5 regions. The high genetic structure detected in H. armiger could be a consequence of poor dispersal ability, local adaptation, or marked female philopatry. The lack of genetic structure among 3 regions separated by the Gaoligong Range and the Qiongzhou Strait could be due to incomplete lineage sorting. Our estimated times of divergence for H. armiger populations suggested a relatively recent split. The S Yunnan population with the highest genetic diversity and the Hainan population with the lowest genetic diversity should be equally given priority for conservation. Although H. armiger has been shown to carry viruses implicated in human disease, we find little evidence for population mixing. We thus suggest minimizing disturbance to bats’ roosting caves for minimizing the potential risk of virus transmission.

  K.F. Chang , S.F. Hwang , A.H. Khadhair , H.U. Ahmed , S.E. Strelkov , M. Deyholos , G.D. Turnbull and J. Feng
  During the summer of 2003 and 2004, a total of 58 isolates of Ascochyta rabiei were collected from chickpea plants grown in southern Alberta, Canada. RAPD analysis of genomic DNA extracted from these isolates was conducted using six short sequence primers (OPA-03, OPA-13, OPB-07, OPC-01, OPC-20 and OPJ-15) and analyzed to establish the genetic relationship and distance between isolates. A total of 75 bands were polymorphic. The 58 isolates were found to belong to five genotypes, indicating that the A. rabiei population of southern Alberta is genetically diverse. No relationship was found between the genotype groupings obtained through RAPD analysis and previously determined pathotype classifications of the same isolates.
  W.J. Li , J. Feng , K.F. Chang , R.L. Conner , S.F. Hwang , S.E. Strelkov , B.D. Gossen and D.L. McLaren
  To identify Quantitative Trait Loci (QTL) controlling root rot resistance of field pea (Pisum sativum L.), 213 Simple Sequence Repeats (SSR) were screened against a population of Recombinant Inbred Lines (RIL) derived from crosses between a moderately resistant cultivar Carman and a susceptible cultivar Reward. Phenotypic data were obtained following inoculation of pea plants with Fusarium avenaceum (Corda ex Fries) Sacc. in field experiments conducted during 2009 and 2010. Linkage analysis based on a single factor ANOVA indicated that four markers were associated with root rot resistance. QTL analysis based on these four markers identified a QTL on Chromosome VII that explained 21.7% of the variance in resistance. The microsatellite markers that are closely linked to this QTL may be useful for stacking QTLs from Carman and other resistance sources to develop cultivars with superior fusarium root rot resistance.
  J. Feng , B. Xiao , J.C. Chen and C.T. Zhou
  Bulk crystal properties of Ag2SnO3 were investigated with the advantage of density functional theory. The whole structure has layered feature: hexagonal metallic planes formed by Ag atoms and distorted octahedrons of SnO6 clusters are configured alternatively along c axis of hexagonal cell. The cohesive energy is about –2.792 eV/atom, which is less than SnO2. The Debye temperature of Ag2SnO3 is about 231.6 K, and the bulk and shear moduli are 62.13 and 20.63 GPa, respectively. Band structure and DOS show the compound has a small pseudo-band gap value of 1.0 eV and so may be a semiconductor. When checking the PDOS intensity at the Fermi surface of Ag atoms, a weak metallic character can be seen. The distortion mechanism becomes less effective to reduce the total orbital energy both in SnO2 and in Ag2SnO3 and as a result the bond lengths of Sn–O are intended to be isotropy.
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