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Articles by J. Bajwa
Total Records ( 5 ) for J. Bajwa
  N.S. Gill , J. Bajwa , K. Dhiman , P. Sharma , S. Sood , P.D. Sharma , B. Singh and M. Bali
  The objective of present study was to evaluate the therapeutic potential of Cucumis melo seeds traditionally consumed and it was studied for free radical scavenging potential by hydrogen peroxide (H2O2) and DPPH method. Anti-inflammatory activity was evaluated using carrageenan-induced paw edema in rats. Analgesic activity was evaluated by tail immersion and tail flick methods in mice. The percentage scavenging of DPPH radical and H2O2 radical was 74.9% at 300 μg mL-1 and 58.91% at 200 μg mL-1 respectively concentration of. The H2O2 scavenging effect of MECM was 58.91%. The percentage reduction of paw edema was 56.6% at the dose of 300 mg kg-1. The high dose caused significant reduction in pain. Thus it can be concluded from the above results that Cucumis melo seeds have potent anti-inflammatory, antioxidant and analgesic activity.
  N.S. Gill , K. Dhiman , J. Bajwa , P. Sharma and S. Sood
  The present study was designed to investigate the free radical scavenging, anti-inflammatory and analgesic potential of methanolic extract of Benincasa hispida seeds (MEBH). Free radical scavenging potential of MEBH was evaluated by DPPH (1,1-diphenyl-2-picryl-hydrazyl) and hydrogen peroxide (H2O2) method. The extract showed significant free radical scavenging activity in a dose dependent manner when compared with ascorbic acid. The highest radical scavenging activity of MEBH was found to be 79.8% at concentration of 300 μg mL-1. The H2O2 scavenging effect of MEBH was 63.7% at a concentration of 200 (μg mL-1). Further, the extract was studied for its anti-inflammatory and analgesic activities at the dose level of 100, 200 and 300 mg kg-1. Anti-inflammatory activity was evaluated using carrageenan-induced paw edema in rats. Analgesic activity was evaluated by tail immersion and tail flick methods in mice. The extract showed significant decrease in paw volume (59.7% reduction) and pain at the dose level of 300 mg kg-1 when compared with reference drug diclofenac and morphine, respectively. The MEBH may be useful as a natural antioxidant in the treatment of inflammation and pain.
  N.S. Gill , J. Bajwa , P. Sharma , K. Dhiman , S. Sood , P.D. Sharma , B. Singh and M. Bali
  The present study was to investigate the anti-ulcer activity of methanolic extract of Cucumis melo (MECM) seeds. The seeds were extracted with methanol and the extract was evaluated for its free radical scavenging activity by DPPH. It shows maximum antioxidant activity. Thus extract was further evaluated against gastric ulcerations by Pyloric Ligation (PL), Water Immersion Stress (WIS) and NSAID (indomethacin) induced ulcer (NIU) models. In case of PL method, the extract inhibited gastric ulcerations in a dose-related manner (150 and 300 mg kg-1). Then it was evaluated for gastric volume, free acidity, total acidity, ulcerative index. The ulcerative index was also measured in WIS model and NIU with same doses. The MECM caused 57.6, 67.6 and 61.9% inhibition of ulcers in pyloric ligation, water immersion stress, NSAID induced ulcer models respectively at 300 mg kg-1. The results concluded that MECM possess high antiulcer potential which is due to its higher antioxidant activity.
  N.S. Gill , P. Sharma , J. Bajwa , K. Dhiman , S. Sood , P.D. Sharma and M. Bali
  The present study was designed to investigate Cucumis melo var. utilissimus seeds for their antioxidant and therapeutic potential. The antioxidant activity of methanolic extract was measured by DPPH method and hydrogen peroxide free radical scavenging activity. The methanolic extract of Cucumis melo var. utilissimus seeds (MECU) showed maximum antioxidant potential. Hence, it was further evaluated for anti-inflammatory activity by carrageenan induced rat paw edema and analgesic activity by tail immersion method and tail flick method at different concentrations, i.e., 100, 200 and 300 mg kg-1. The significant results was found at maximum dose. The results suggested that methanolic seed extract possess great therapeutic potential.
  N.S. Gill , K. Dhiman , P. Sharma , J. Bajwa , S. Sood , P.D. Sharma , B. Singh and M. Bali
  In the present study free radical scavenging and antiulcer potential of Benincasa hispida seeds was evaluated. The powdered seeds were extracted with methanol. The extract was evaluated for its free radical scavenging activity by DPPH method followed by antiulcer activity using pyloric ligation, water immersion stress and NSAID (indomethacin) induced gastric ulcer model (NIU) in rats. The parameters assessed were gastric volume, free acidity, total acidity, ulcer index and percentage ulcer protection. Ranitidine was used as the reference antiulcer drug. The methanolic extract showed concentration dependent DPPH radical scavenging activity. The methanolic extract of Benincasa hispida seeds (MEBH) inhibited gastric ulceration by decreasing the gastric volume, free and total acidity. The high dose (300 mg kg-1) showed significant reduction in the above parameters which was comparable to the standard drug ranitidine (p<0.05). The MEBH caused 52.7, 67.4 and 61.2% inhibition of ulcers in pyloric ligation, water immersion stress and NSAID induced ulcer models, respectively at 300 mg kg-1. Thus it can be concluded that the seeds of Benincasa hispida possess potent antiulcer activity. The antiulcer action may be exerted through free radical scavenging mechanism.
 
 
 
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