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Articles by J. Y Cha
Total Records ( 2 ) for J. Y Cha
  Y. M Cho , J. Y Cha and C. J. Hwang

The aim of this study was to evaluate the effect of the direction and magnitude of the rotation moment to loaded orthodontic miniscrews on stability.

In six adult male beagle dogs (12 months old), 36 orthodontic miniscrews were inserted into the mandibular buccal alveolar bone without drilling. Immediately after insertion, 24 miniscrews were loaded with 1- and 2-Ncm nickel titanium (NiTi) coil springs with either a clockwise or counterclockwise rotation moment while 12 miniscrews were left unloaded. Following an observation period of 3 or 12 weeks, the animals were killed and the miniscrews with the surrounding bone were prepared for histomorphometric evaluation. Bone-to-implant contact (BIC) and the ratio of bone volume/total volume (BV/TV) were measured. BIC and BV/TV were statistically compared using the Kruskal–Wallis H and Mann–Whitney U tests.

Three of the miniscrews loaded with 2 Ncm counterclockwise rotation moment were lost within 3 weeks. At 12 weeks after insertion, the counterclockwise group showed a statistically significantly lower BIC in comparison with the clockwise group.

The results suggest that a rotation moment to loaded orthodontic miniscrews, as well as the direction and magnitude of the rotation moment, can influence miniscrew stability. Counterclockwise rotational moments can be a risk factor impairing miniscrew stability.

  S. M Ahn , T. H Kim , S Lee , D Kim , H Ghang , D. S Kim , B. C Kim , S. Y Kim , W. Y Kim , C Kim , D Park , Y. S Lee , S Kim , R Reja , S Jho , C. G Kim , J. Y Cha , K. H Kim , B Lee , J Bhak and S. J. Kim

We present the first Korean individual genome sequence (SJK) and analysis results. The diploid genome of a Korean male was sequenced to 28.95-fold redundancy using the Illumina paired-end sequencing method. SJK covered 99.9% of the NCBI human reference genome. We identified 420,083 novel single nucleotide polymorphisms (SNPs) that are not in the dbSNP database. Despite a close similarity, significant differences were observed between the Chinese genome (YH), the only other Asian genome available, and SJK: (1) 39.87% (1,371,239 out of 3,439,107) SNPs were SJK-specific (49.51% against Venter's, 46.94% against Watson's, and 44.17% against the Yoruba genomes); (2) 99.5% (22,495 out of 22,605) of short indels (< 4 bp) discovered on the same loci had the same size and type as YH; and (3) 11.3% (331 out of 2920) deletion structural variants were SJK-specific. Even after attempting to map unmapped reads of SJK to unanchored NCBI scaffolds, HGSV, and available personal genomes, there were still 5.77% SJK reads that could not be mapped. All these findings indicate that the overall genetic differences among individuals from closely related ethnic groups may be significant. Hence, constructing reference genomes for minor socio-ethnic groups will be useful for massive individual genome sequencing.

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