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Articles by J. L. C Lin
Total Records ( 1 ) for J. L. C Lin
  Q Wang , J. L. C Lin , B. E Reinking , H. Z Feng , F. C Chan , C. I Lin , J. P Jin , E. A Gustafson Wagner , T. D Scholz , B Yang and J. J. C. Lin
 

Rationale: The Xin repeat–containing proteins mXin and mXinβ localize to the intercalated disc of mouse heart and are implicated in cardiac development and function. The mXin directly interacts with β-catenin, p120-catenin, and actin filaments. Ablation of mXin results in adult late-onset cardiomyopathy with conduction defects. An upregulation of the mXinβ in mXin-deficient hearts suggests a partial compensation.

Objective: The essential roles of mXinβ in cardiac development and intercalated disc maturation were investigated.

Methods and Results: Ablation of mXinβ led to abnormal heart shape, ventricular septal defects, severe growth retardation, and postnatal lethality with no upregulation of the mXin. Postnatal upregulation of mXinβ in wild-type hearts, as well as altered apoptosis and proliferation in mXinβ-null hearts, suggests that mXinβ is required for postnatal heart remodeling. The mXinβ-null hearts exhibited a misorganized myocardium as detected by histological and electron microscopic studies and an impaired diastolic function, as suggested by echocardiography and a delay in switching off the slow skeletal troponin I. Loss of mXinβ resulted in the failure of forming mature intercalated discs and the mislocalization of mXin and N-cadherin. The mXinβ-null hearts showed upregulation of active Stat3 (signal transducer and activator of transcription 3) and downregulation of the activities of Rac1, insulin-like growth factor 1 receptor, protein kinase B, and extracellular signal-regulated kinases 1 and 2.

Conclusions: These findings identify not only an essential role of mXinβ in the intercalated disc maturation but also mechanisms of mXinβ modulating N-cadherin–mediated adhesion signaling and its crosstalk signaling for postnatal heart growth and animal survival.

 
 
 
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