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Articles by J. Anbu Jeba Sunilson
Total Records ( 4 ) for J. Anbu Jeba Sunilson
  J. Anbu Jeba Sunilson , R. Suraj , G. Rejitha , K. Anandarajagopal , A.V. Anita Gnana Kumari and P. Promwichit
  In the present study, antimicrobial activity of various extracts of Zingiber officinale, Curcuma longa and Alpinia galanga were screened against the common food borne bacteria such as Escherichia coli, Salmonella enteriditis, Clostridium perfringens, Staphylococcus aureus, Campylobacter jejuni, Bacillus cereus and fungi such as Saccharomyces cerevisiae, Hansenula anomala, Mucor mucedo, Candida albicans using disc diffusion method. All the extracts showed significant antibacterial and antifungal properties. The methanol extracts (100 μg mL-1) revealed maximum zone of inhibition (p<0.001). Zingiber officinale and Curcuma longa possessed considerably greater activity than Alpinia galanga. These findings established the potential of the selected rhizomes of Zingiberaceae family as effective natural food preservatives.
  J. Anbu Jeba Sunilson , A.V. Anita Gnana Kumari , Abdullah Khan and K. Anandarajagopal
  Background and Objective: Medicinal plants have a vital role in the development of novel antimicrobial agents. The fruit Malus domestica is known as apple and commonly used to prevent tooth decay by killing dental pathogens. However, there were no scientific reports about the fruits of Malus domestica having antimicrobial activity against dental pathogens. The aim of this study was to extract the active constituents present in the fruits of Malus domestica by cold maceration method using petroleum ether, ethanol and water. Methodology: The antibacterial activity was assessed by cup plate method against five isolated dental pathogens such as Staphylococcus aureus, Streptococcus mutans, Lactobacillus subtilis, Klebsiella sp. and Pseudomonas sp. and the radial zone of inhibition was measured. Results: The results revealed that the ethanol extract (100 mg mL–1) has more potent antibacterial activity against S. aureus, S. mutans and Pseudomonas sp., followed by aqueous extract (100 mg mL–1) whereas, petroleum ether extract (100 mg mL–1) has not shown any zone of inhibition against the tested microorganisms. All the results were compared with standard drug chlorhexidine 0.2% w/v. Conclusion: Hence, the study concludes that Malus domestica fruit extracts possess significant (p<0.001, p<0.01, p<0.05) antibacterial activity against dental pathogens. The phyto chemical tests on ethanol extract showed the presence of bioactive constituents such as terpenoids, flavonoids, phenolic compounds and tannins which could be responsible for the antibacterial activity of M. domestica fruit.
  J. Anbu Jeba Sunilson , R. Varatharajan , P. Jayaraj , T. John , J. Jisha and P. Promwichit
  Ethanol extract of Hibiscus aculeatus (HAE) was assessed in different acute and chronic gastric ulcer models in rats. HAE, 50-200 mg kg-1 administered orally, twice daily for 5 days showed dose-dependent ulcer protective effect in pylorus ligation (9.21-52.63% protection, p<0.05), aspirin (23.95-56.25% protection, p<0.05), ethanol (13.55-58.47% protection, p<0.05), cold-restraint stress (18.34-72.92% protection, p<0.05 to p<0.001) and acetic acid (p<0.05 to p<0.001) induced acute and chronic ulcers. HAE also significantly (p<0.001) reduced the ulcer incidence (40 and 10%) and severity (54.35 and 85.37% protection) of duodenal ulcer, induced by cysteamine. HAE offered protection (49.57 and 58.97%) against ethanol-induced depletion of gastric wall mucus. And also, HAE reduced the ulcer index with significant decrease in plasma corticosterone (21.15 and 33.51% protection, p<0.05), lipid peroxidation (16.66 and 38.88% protection, p<0.01 and p<0.001), superoxide dismutase (17.64 and 47.25% protection, p<0.05 and p<0.001) and an increase in catalase (25.84 and 83.14% protection, p<0.05 and p<0.001) activity respectively. Preliminary phytochemical screening of the HAE showed positive test for flavanoids, terpenoids, steroids, tannins and saponins. The results indicate that HAE possesses gastroprotective and antioxidant activity.
  J. Anbu Jeba Sunilson , M. Muthappan , Amitava Das , R. Suraj , R. Varatharajan and P. Promwichit
  Coccinia grandis Linn. (Cucurbitaceae) is a perennial branched handsome tendril climber, distributed through out India. It has been used in folk medicine for the treatment of jaundice. The aim of this work was to study the hepatoprotective effect of crude ethanolic and aqueous extracts from the leaves of C. grandis against liver damage induced by CCl4 in rats. The ethanolic extract at an oral dose of 200 mg kg -1 exhibited a significant (p<0.05) protective effect as shown by lowering serum levels of glutamic oxaloacetic transaminase, glutamic pyruvic transaminase, alkaline phosphatase, total bilirubin and total cholesterol and increasing levels of total protein and albumin levels as compared to silymarin, the positive control. These biochemical observations were supported by histopathological examination of liver sections. The activity may be due to the presence of flavonoid compounds. The extracts showed no signs of acute toxicity up to a dose level of 2000 mg kg -1. Thus it could be concluded that ethanolic extract of C. grandis leaves possesses significant hepatoprotective activity.
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