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Articles by J Tremblay
Total Records ( 3 ) for J Tremblay
  T Guiraud , L Leger , A Long , N Thebault , J Tremblay and P. Passelergue
  Background and aims

The validity of five brands of cycle ergometers was evaluated by the comparison of the Vo2 requirements at different displayed power.

Methods and results

Five physically active men performed a continuous incremental exercise test on five ergometers (Ergomeca, Lifecycle, Monark, Polar S710 and CompuTrainer). The latter was also compared with a standard dynamometer in order to associate Vo2 values with the real power. Every test started with a 5-min warm-up on the same cycle ergometer (Ergomeca) at 100 W to make sure that the Vo2 differences do not come from Vo2 measurement error. Only last minute steady-state Vo2 values of each 2-min stage were used for the Vo2–watt curve. Large differences (5– 10 ml kg–1 min–1) at the same displayed power indicate inaccuracy of displayed power output (PO). Using corrected power values from the dynamometer revealed that for the same Vo2 the CompuTrainer underestimates PO by ~30 W between 100 and 300 W, whereas the Lifecycle overestimate it by 3–53 W from 100 to 300 W. The Monark and Polar S710 underestimate PO by 15 W and the Ergomeca by ~5 W.


Inaccuracies between –10% and 18% in displayed PO of various cycle ergometers question their interchangeability.

  Z Pausova , C Syme , M Abrahamowicz , Y Xiao , G. T Leonard , M Perron , L Richer , S Veillette , G. D Smith , O Seda , J Tremblay , P Hamet , D Gaudet and T. Paus

Background— FTO is the first gene established as contributing to common forms of obesity. The gene is highly expressed in the hypothalamus and is thought to mediate this effect through its influence on energy homeostasis. The hypothalamus, however, also regulates blood pressure (BP). Therefore, we investigated whether the FTO-risk variant is associated not only with increased adiposity but also with elevated BP and whether the latter may be mediated, in part, by increased sympathetic modulation of vasomotor tone.

Methods and Results— The primary study was carried out in 485 adolescents recruited from a French Canadian founder population who underwent detailed body-composition and cardiovascular phenotyping. Body fat was examined with MRI, bioimpedance, and anthropometry. BP was recorded beat to beat at rest and during physical and mental challenges. Sympathetic modulation of vasomotor tone was assessed with power spectral analysis of BP. We found that individuals with the FTO-risk genotype compared with those without it demonstrate greater adiposity, including the amount of intra-abdominal fat (by 38%). They also showed higher systolic BP throughout the entire protocol, with a maximum difference during a mental stress (6.4 [1.5 to 11.3] mm Hg). The difference in BP was accompanied by elevated index of sympathetic modulation of vasomotor tone. A replication in an independent sample of adults from the same founder population confirmed the association between FTO and BP.

Conclusions— These results suggest that, in a French Canadian founder population, FTO may increase not only risk for obesity, as demonstrated in other populations, but also for hypertension. The latter may be related, at least in part, to the regulation of sympathetic vasomotor tone.

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