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Articles by J Kassotis
Total Records ( 2 ) for J Kassotis
  R Castillo , A Fields , G Qureshi , L Salciccioli , J Kassotis and J. M. Lazar

Prior studies have suggested an association between atherosclerosis and periodontal disease, both of which are more prevalent in certain minority and economically disadvantaged groups. Few studies have addressed the relationship between cardiovascular disease and dentition among ethnically diverse populations. We studied 131 subjects (60% females, age 59 ± 15 years) who were referred for clinically indicated transesophageal echocardiography. Dental loss was more severe in patients with hypertension (P < .001), diabetes (P = .05), coronary artery disease (P = .04), and calcium channel blocker use (P = .04). On univariate analysis, maximal aortic intima—media thickness (MAIMT) was significantly correlated with dental loss (r = .40; P < .001). Age was correlated with MAIMT (R = .41; P < .001) and with dental loss (r = .57; P < .001). On multivariate analysis, dental loss (P = .03) and history of coronary artery disease (P = .04) were independent predictors of MAIMT ( R2 = .44). In this inner-city predominantly African American population, atherosclerosis and dental loss are age dependent and are interrelated independent of age.

  H Kamran , L Salciccioli , Eun Hee Ko , H Kazmi , J Kassotis and J. Lazar

This pilot study assessed the effects of hyperemia on carotid-radial pulse wave velocity (PWV) in 39 normotensive (NT) and 23 hypertensive (HT) participants using applanation tonometry. Pulse wave velocity was measured at 1- and at 2-minute intervals. Baseline PWV was similar between the groups (P = .59). At 1 minute, PWV decreased (8.5 ± 1.2 to 7.1 ± 1.4 m/s, P < .001) in NT but not in HT (P = .83). Hyperemic PWV (PWV) response differed between the groups (-16% vs + 1.0%, P < .001). On multivariate analysis, HT, not age or blood pressure was independently related to PWV (R2 = .43, P < .01). Among patients with cardiovascular risk factors/disease, PWV was inversely related to flow-mediated dilation (FMD; R 2 = .43, P < .003). Conclusion: hyperemia decreases PWV1min in NT but not in HT. PWV is inversely related to FMD. Blunted hyperemic PWV response may represent impaired vasodilatory reserve.

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