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Articles by Innocent Pierre Guissou
Total Records ( 3 ) for Innocent Pierre Guissou
  Yamba Ouedraogo , Innocent Pierre Guissou and Odile Germaine Nacoulma
  We reported the results of biological and toxicological study, realized on Mitragyna inermis Willd Oktze, one specie of family of Rubiaceae, well known in traditional medicine in Burkina Faso for his intensification potentialities of resistance against multiple pathologies like infectious and parasitic diseases, adynamia, rheumatic and osteoarthritis diseases. So we have formulated hypothesis of stimulation of organism’s defenses for a scientist research. The steeping freeze-dried of the plant’s product has been used for different assays: General acute toxicity estimation on Ico mouse (NMRI Han) by intraperitoneal route and orally administration on rabbit from the value of LD50 obtained with the mouse. Biological study: The kinetic interaction between the plant’s product chemical group and the evolution of biological elements medium of immunity on the rabbit, has been appreciated. The biological elements include white blood cells, red blood cells, lymphocytes, platelets, total proteins, albumin and globulins. The following results have been obtained about the study: A Lethal Dose (LD50) resulted from maceration (acute general toxicity) at the rate of 800 mg kg-1 of corporal weight showing a bit toxic product. An interaction between vegetable’s extract chemical group and biological elements of rabbit which is expressed by: An increasing (13 to 18%) of total proteins from serum; this increasing was notably after 24 h of administration. Albumin decreasing of 10% in comparison with initial rate, indicated haptens action of plant’s extract chemical products. α1, α2, β and γ globulins increasing, respectively 46.8, 14.31 and 26% during the first day of administration of the extract. A lymphocyte increasing of 35% 24 h after administration of the product. This rate is more increased after the second administration; White blood cells are also increasing. These results show an obvious capacity of the plant’s macered extract to stimulate organism natural defenses in relation with antigenous-antibody reaction. This will be an interesting perspective for complementary treatment of pathology like HIV diseases.
  Wamtinga Richard Sawadogo , Aline Meda , Charles Euloge Lamien , Martin Kiendrebeogo , Innocent Pierre Guissou and Odile Germaine Nacoulma
  In this study the total phenolic and flavonoid content as well as the antioxidant activity of six Acanthaceae namely Blepharis lineariifolia PERS, Dicliptera verticillata (FORRSK.) C. CHRISTENS, Dyschoriste perrottetii (NEES) O. KTZE, Hygrophila auriculata (SCHUMACH.) HEINE, Lepidagathis anobrya NEES, Nelsonia canescens (LAM) SPRENG were evaluated. The total phenolic and flavonoid of their aqueous acetone extract were assessed by Folin-ciocalteu and AlCl3 method, respectively, whereas the antioxidant activities were determined by the DPPH method. Lepidagathis anobrya, Hygrophila auriculata and Nelsonia canescens which had the highest phenolic content, were found to possess the best antioxidant activities. The results suggest that these plants are good sources of antioxidants and support their use in cardiovascular and antiinflammatory diseases.
  Abdel Magid Ouoba , Noya Some , Jean Koudou , Sylvin Ouedraogo and Innocent Pierre Guissou
  The main goal of this study was to determine the acute toxicity and irritancy of the leaf of essential oil of Vitex simplicifolia Oliv. (Verbenaceae) growing in Burkina Faso and whose therapeutic use is multiple. The acute toxicity of the essential oil was determined by Litchfield method. Skin and eye irritancy was performed by Draize method. The acute toxicity of essential oil was evaluated to give a LD50 = 2830.77±299.22 mg kg-1 and showed that the essential oil of Vitex simplicifolia is slightly toxic. Skin and eye irritation was evaluated and showed that essential oil of this plant is slightly irritating with a primary irritation index PI = TEO/16 = 0.75, an Acute Ocular Index, Ac.O.I. =12.83, an Average Ocular Index, Av.O.I. of less than 5 after 48 h. The results suggest that the leaf essential oil of Vitex simplicifolia Oliv. possessed slightly toxic and slightly irritancy activities. It could be used as natural potential ingredient for pharmaceutical industry.
 
 
 
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