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Articles by Inchirah Karmous
Total Records ( 2 ) for Inchirah Karmous
  Houda Ben Jemaa , Sarra Khlifi , Halima Ben Hmed , Inchirah Karmous , Anis Benzarti , Jalila Elati and Abdallah Aouidet
  Artemisia herba alba was widely used in traditional medicine for the treatment of diabetes. The objective of this study was to evaluate the antidiabetic, antihyperlipidemic and antioxidant effects of Artemisia herba alba extract on high fat diet and diabetic models. Wistar albinos male rats were divided into four groups, the first was fed with high fat diet, the second was mimetic diabetes type II with high fat diet combined with double low dose of streptozotocin , the third was a model of type I diabetes with high dose of streptozotocin and the fourth was a control group. The ethanolic extract of Artemisia herba alba was given orally (2 g kg-1 b.wt.) and daily for a period of 8 weeks. Our results showed that Artemisia herba alba treatment reduces the blood glucose level significantly in type II diabetic group (17.50±2.34 g L-1 vs., 10.93±3.19 g L-1). The plasma lipoproteins HDL, LDL-cholesterol and the triglyceride levels were altered by high fat diet and also by streptozotocin injection. These levels were also reverted back to near normalcy by treatment. Lipid peroxidation was decreased significantly by Artemisia herba alba supplementation in high fat diet and diabetic groups (p<0.05). Treatment with investigational drug increases antioxidant enzymes activities (superoxide dismutase and catalase in liver and kidneys) for type I and type II diabetic groups. In conclusion, this study suggests that the Artemisia herba alba has a beneficial effect in controlling diabetes by reducing lipid peroxidation and increasing antioxidant enzymes activities, which reduces the risk of developing diabetes complications.
  Sarra Khlifi , Houda Ben Jemaa , Halima Ben Hmad , Hajer Abaza , Inchirah Karmous , Abdelmajid Abid , Anis Benzarti , Jalila Elati and Abdallah Aouidet
  Fenugreek (Trigonella foenum-graecum) seeds have been known as a traditional plant treatment for diabetes. The aims of this study were to determine the antioxidant activity of fenugreek seeds and to evaluate the antidiabetic and antihyperlipidemic effect of fenugreek seeds intake on diabetic patients. Sixty newly diagnosed diabetic patients were recruited for this study and have received two doses of fenugreek seeds (2.5 and 5 g) for 4 weeks. Phytochemicals analysis and antioxidant activity of Trigonella foenum-graecum seeds methanolic extract were also studied. The chemical analysis of fenugreek seeds exhibited a high level in total polyphenols (9.5 GAE g/g VM) and flavonoids (3.7 mg RE/g VM). Fenugreek seeds exertan important DPPH scavenging ability in terms of Trolox Equivalents (TE) with 1.03±0.008 mg TE/g VM and also exhibited a high antioxidant potential according to ABTS test. In Tunisian type 2 diabetic patients, the administration of fenugreek seeds (2.5 and 5 g) for 4 weeks improved blood glucose level in dose-dependent. Total cholesterol and triglycerides rate were significantly decreased by the dose of 5 g Trigonella foenum-graecum seeds. Moreover, daily oral intake of our treatment by diabetic subjects reduced significantly serum α-amylase activity. The present findings indicate that fenugreek seeds with abundant flavonoids and total polyphenols content may be a good adjuvant for the treatment of diabetes.
 
 
 
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