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Articles by Ikewuchi Jude Chigozie
Total Records ( 1 ) for Ikewuchi Jude Chigozie
  Ikewuchi Jude Chigozie and Ikewuchi Catherine Chidinma
  In this study, the effects of an aqueous extract of the rhizomes of Sansevieria senegambica on the haematology, plasma biochemistry and ocular indices of oxidative stress were investigated in alloxan induced diabetic rats. Diabetes mellitus was induced by injection of alloxan (80 mg kg-1 body weight), via the tail vein. The extract was administered orally at 100, 200 and 300 mg kg-1 (both to normal and diabetic rats) and metformin at 50 mg kg-1. On gas chromatographic analysis of the flavonoid fraction of the crude aqueous extract, twenty nine known flavonoids were detected, consisting mainly of 31.46% apigenin, 20.47% quercetin, 11.21% kaempferol, 5.75% (-)-epicatechin, 5.75% naringenin, 3.60% biochanin, 3.58% (+)-catechin. Compared to test control, the treatment significantly lowered (p<0.05) ocular malondialdehyde content, atherogenic indices, total white cell and monocyte counts; and plasma levels of glucose, triglyceride, total-, very low density lipoprotein-, low density lipoprotein- and non-high density lipoprotein cholesterols, total and conjugated bilirubins, total protein, sodium, urea, blood urea nitrogen, as well as plasma activities of alkaline phosphatase, alanine and aspartate transaminases. However, the treatment significantly increased (p<0.05) haematocrit, haemoglobin concentration, red cell, lymphocyte and platelet counts, mean cell volume, ocular vitamin C content and plasma levels of high density lipoprotein cholesterol, potassium, chloride and bicarbonate and ocular activities of catalase and superoxide dismutase. Besides confirming the presence of pharmacologically active compounds in the rhizome extract, this study also showed the hypoglycemic, hypolipidemic, anti-anemic, immune-modulating, ocular-, hepato-renal and cardio-protective potentials of the extract. All these, support the use of the rhizomes of Sansevieria senegambica in African traditional health care practices for the management of diabetes mellitus.
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