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Articles by Ibrahim Dan Dano
Total Records ( 2 ) for Ibrahim Dan Dano
  Ibrahim Dan Dano , Sani Ousmane and Hassimi Sadou
  Many studies have investigated the potential of using cerebrospinal fluid (CSF) interleukin-6 levels for the diagnosis of meningitis, but they have often provided contradictory results. This critical scientific literature review summarizes various methods used for the diagnosis of bacterial meningitis, including IL-6 assays and the diagnostic power of CSF IL-6 as a biomarker of bacterial meningitis, between 2000 and 2016. An analysis of data from 9 studies involving 292 patients with bacterial meningitis revealed that sample sizes of patients with bacterial meningitis ranged from 9-85. Molecular methods were used to diagnose bacterial meningitis in only one of these studies. Enzyme-linked immunosorbent assays (ELISA) were used in 5 of these studies to determine CSF IL-6 levels. The reported area-under the curve (AUC) varied from 0.660-0.988 and in 6 out of 8 (75%) studies it was >0.937. The CSFIL-6 cut-off values for the diagnosis of bacterial meningitis ranged from 90 pg dL–1 to 51.6 ng mL–1 and the sensitivity and specificity of the assays ranged from 61.9-100 and 51-100%, respectively. Different methods were used to determine CSF IL-6 levels and the identification of bacterial meningitis was mostly based on culture without an associated molecular method. There is a need to standardize methods to ensure accurate diagnoses. Further studies that recruit a large number of patients with bacterial meningitis are required to validate these findings.
  Ibrahim Dan Dano , Hassimi Sadou , Bassira Issaka and Odile Ouwe Missi Oukem-Boyer
  Objective: It is assessed whether the measurement of interleukin-6 in the cerebrospinal fluid can serve as a biomarker for the diagnosis of bacterial meningitis. Methodology: Cerebrospinal fluid was obtained from 152 patients aged 0-15 years suspected of having meningitis. These patients were classified into the following groups: Bacterial meningitis (n = 85), aseptic meningitis (n = 35) and non-meningitis/control (n = 32) based on leukocyte count and bacterial identification by culture and molecular biology. Interleukin-6 concentrations in cerebrospinal fluid were measured by enzyme-linked immunosorbent assay. Results: This study found a significant difference of the mean cerebrospinal fluid interleukin-6 level (p≤0.01) between patients with bacterial meningitis (3,538.69±2,560.78 pg mL–1) and patients with aseptic meningitis (332.51±470.69 pg mL–1) or those of the control group (205.83±79.39 pg mL–1). There was also a significant difference of the mean cerebrospinal fluid interleukin-6 level between patients with aseptic meningitis and those of the control group. Interleukin-6 had the highest area under the ROC curve: 0.94 (95% confidence interval: 0.901-0.979) compared to that of cerebrospinal fluid glucose and total protein. At a cut-off value of 1,065.96 pg mL–1, interleukin-6 had a sensitivity of 76.2% and specificity of 100%. Conclusion: Interleukin-6 is a potential biomarker for the differential diagnosis of meningitis.
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