Asian Science Citation Index is committed to provide an authoritative, trusted and significant information by the coverage of the most important and influential journals to meet the needs of the global scientific community.  
ASCI Database
308-Lasani Town,
Sargodha Road,
Faisalabad, Pakistan
Fax: +92-41-8815544
Contact Via Web
Suggest a Journal
 
Articles by Ibrahim Dan Dano
Total Records ( 2 ) for Ibrahim Dan Dano
  Ibrahim Dan Dano , Sani Ousmane and Hassimi Sadou
  Many studies have investigated the potential of using cerebrospinal fluid (CSF) interleukin-6 levels for the diagnosis of meningitis, but they have often provided contradictory results. This critical scientific literature review summarizes various methods used for the diagnosis of bacterial meningitis, including IL-6 assays and the diagnostic power of CSF IL-6 as a biomarker of bacterial meningitis, between 2000 and 2016. An analysis of data from 9 studies involving 292 patients with bacterial meningitis revealed that sample sizes of patients with bacterial meningitis ranged from 9-85. Molecular methods were used to diagnose bacterial meningitis in only one of these studies. Enzyme-linked immunosorbent assays (ELISA) were used in 5 of these studies to determine CSF IL-6 levels. The reported area-under the curve (AUC) varied from 0.660-0.988 and in 6 out of 8 (75%) studies it was >0.937. The CSFIL-6 cut-off values for the diagnosis of bacterial meningitis ranged from 90 pg dL–1 to 51.6 ng mL–1 and the sensitivity and specificity of the assays ranged from 61.9-100 and 51-100%, respectively. Different methods were used to determine CSF IL-6 levels and the identification of bacterial meningitis was mostly based on culture without an associated molecular method. There is a need to standardize methods to ensure accurate diagnoses. Further studies that recruit a large number of patients with bacterial meningitis are required to validate these findings.
  Ibrahim Dan Dano , Hassimi Sadou , Bassira Issaka and Odile Ouwe Missi Oukem-Boyer
  Objective: It is assessed whether the measurement of interleukin-6 in the cerebrospinal fluid can serve as a biomarker for the diagnosis of bacterial meningitis. Methodology: Cerebrospinal fluid was obtained from 152 patients aged 0-15 years suspected of having meningitis. These patients were classified into the following groups: Bacterial meningitis (n = 85), aseptic meningitis (n = 35) and non-meningitis/control (n = 32) based on leukocyte count and bacterial identification by culture and molecular biology. Interleukin-6 concentrations in cerebrospinal fluid were measured by enzyme-linked immunosorbent assay. Results: This study found a significant difference of the mean cerebrospinal fluid interleukin-6 level (p≤0.01) between patients with bacterial meningitis (3,538.69±2,560.78 pg mL–1) and patients with aseptic meningitis (332.51±470.69 pg mL–1) or those of the control group (205.83±79.39 pg mL–1). There was also a significant difference of the mean cerebrospinal fluid interleukin-6 level between patients with aseptic meningitis and those of the control group. Interleukin-6 had the highest area under the ROC curve: 0.94 (95% confidence interval: 0.901-0.979) compared to that of cerebrospinal fluid glucose and total protein. At a cut-off value of 1,065.96 pg mL–1, interleukin-6 had a sensitivity of 76.2% and specificity of 100%. Conclusion: Interleukin-6 is a potential biomarker for the differential diagnosis of meningitis.
 
 
 
Copyright   |   Desclaimer   |    Privacy Policy   |   Browsers   |   Accessibility