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Articles by I.P. Oyeyipo
Total Records ( 4 ) for I.P. Oyeyipo
  R.E. Akhigbe , M.O. Azeez , S.F. Ige , I.P. Oyeyipo , F.O. Ajao and A.O. Soladoye
  This study examined the effect of administration of combined Oral Contraceptive (OC) on blood viscosity and associated hemorheological parameters such as plasma viscosity, Pack Cell Volume (PCV), serum albumin, fibrinogen and total plasma proteins. Female wistar rats aged 7-10 weeks were selected and randomly distributed into two groups, the control group and the OC-treated group, with 20 rats in each group. The rats in both groups were fed with standard rat chow. After two weeks of acclimatization, rats in OC-treated group received OC therapy (containing 1.0 μg ethinyloestradiol and 10.0 μg of norgestrel), while rats in the control group remained on standard rat chow. After 7 weeks of treatment, hemorheological parameters were determined using standard hemorheological techniques described by Dacies and Lewis. Unpaired t-test was performed in all data with the significant level set at p<0.05. There was no significant change in level of fibrinogen, while there was significant increase in blood viscosity, plasma viscosity, PCV, serum albumin concentration and total plasma proteins in OC-treated rats. This finding suggests that increase blood viscosity and plasma viscosity seen in OC therapy is associated with an increase in PCV and serum albumin level.
  I.P. Oyeyipo and B.A. Falana
  Dissection of cadaver has been central to medical education since the Renaissance however, there are variety of mixed feelings and emotional reactions experienced by students when they are exposed to human cadavers. This present study was conducted to determine the altitude of pre-clinical students in their 1st year training in a medical school to cadaver dissection in anatomical studies. Questionnaire with 20 statements was administered to 65 students of Osun State University, Osogbo, Nigeria. The questionnaires required them to choose one out of three possible responses; yes, no or undecided as its best and truthfully describe their response to the question. However, out of the 65 students involved in this survey, 60 students responded correctly and completely and their answers were analyzed by descriptive statistics. Majority of the students (70%) found their first visit to the dissection room exciting, 46.7% were upset at the beginning of the dissection while 36.7% showed anxiety and stress immediately before and during dissection. About 76.7% were mentally prepared for dissection and 20% were not. Total 81.7% of the students agreed that dissection enhanced their thinking ability and 93.3% were of the option that dissection provided the best method for learning anatomy. About 90% of them considered cadaver dissection as ethically acceptable while 50% reported that prior experience of a dead body helped them develop a better coping mechanism. Most students (98.3%) considered the dissection of cadaver very important in anatomy learning. Total 86.6 and 91.7% of medical students reported that cadaver dissection is religiously and culturally acceptable, respectively. Conclusively, it may be inferred that cadaver dissection is still significant in anatomy learning.
  O.O. Obembe and I.P. Oyeyipo
  The effect of exercise-training on heart rate and blood pressure both at rest and after an all out effort on a bicycle ergometer was studied in 87 healthy Nigerian males. The age groups of the subjects are 15-19, 20-24, 25-29 and 30-34 years. Results showed that exercise-trained individuals have a significantly lower resting rate (p<0.05) and a significantly lower maximum heart rate (p<0.05) than sedentary individuals in all the age groups. However, no significant difference was recorded in the blood pressure (both systole and diastole) between exercise-trained and sedentary individuals in all the age groups. Endurance training, through improvement of heart efficiency may improve cardiac autonomic balance; increasing parasympathetic while decreasing sympathetic stimulation of the heart. Exercise training results in markedly lower heart rate readings in exercise-trained individuals compared with sedentary individuals.
  B.A. Falana and I.P. Oyeyipo
  Lead is a major environmental metal and a known reproductive toxicant. It causes reproductive toxicity via suppression of spermatogenesis and androgenesis in males. This study investigated the effect of lead exposure and metals supplementation on male reproductive activities in male albino rat. Forty male rats were divided into four groups and treated orally for 30 days with lead, selenium and zinc. Group A which served as the control received distilled water, group B received 2.25 mg kg-1 body weight of lead acetate only C received 2 mg kg-1 body weight of sodium selenium and 500 mg kg-1 BW/day zinc carbonate only group D received 2.25 mg kg-1 body weight lead acetate with 2 mg kg-1 body weight of sodium selenium and 500 mg kg-1 BW/day zinc carbonate. Sperm count, motility, viability, volume and morphology were evaluated while serum Luteinizing (LH) and testosterone levels were assayed. Lead treatment decreased sperm functions: count, viability, volume, motility, normal morphology and serum LH and testosterone. Co-administration of selenium and zinc with lead was found to attenuate the decrease in sperm functions and enhance serum reproductive hormones level. Selenium and zinc treatment only increased sperm count, motility, viability, volume, morphology and hormonal level. This study showed that lead apart from being a hormonal disrupter adversely affect sperm cells which contributed to the reproductive damage in the male rats. The protective effects of selenium and zinc on reproductive toxicity as evidenced by the clear restoration of sperm functions and testicular steroidogenesis indices could be attributed to its antioxidants and androgenic properties.
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