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Articles by I.O. Onoagbe
Total Records ( 2 ) for I.O. Onoagbe
  T.P. Prohp , I.O. Onoagbe , P.C. Onyebuagu , A.A. Omeni , R.I. Okoli and N.P. Obeto
  The effect of aqueous extract of Triplochiton scleroxylon on the body weight, plasma glucose concentration and some hematological parameters in alloxan-induced diabetic rabbits were investigated. Rabbits of the same strain (New Zealand) weighing between 1.20 and 1.68kg were used. At least 100ml of the aqueous extract of the plant was administered to a set of test rabbits for a period of 28 days. Blood was collected for analyses intravenously from the larger vein at the back of the ear of the rabbits. Plasma glucose was analyzed by spectrophotometeric method. Hematological swelab auto - counter 920E+ (UK) was used for red blood cell counts, packed cell volume, hemoglobin and mean corpuscular hemoglobin concentration, mean corpuscular hemoglobin, mean corpuscular volume and red cell distribution width. The aqueous extract of Triplochiton scleroxylon does not have any significant effect (P>0.05) on the body weight and some hematological parameters investigated. However, plasma glucose concentration decreased significantly (P < 0.05) on the 18th, 24th and 28th days of administration of herbal extract to alloxan - induced diabetic rabbits. The crude extract of this herb has an hypoglycemic properties and its use as an anti-diabetic agent may not interfere with the body weight and some hematological properties of rabbits and by extrapolation humans.
  T. P. Prohp , A.O. Madusha , I.O. Onoagbe , U. Inegbenebor and R. I. Okoli
  Some of the effects of the aqueous leaf extract of Pride of Barbados (Caesalpina pulcherrima) on the activities of plasma glutamic pyruvate transaminase (GPT), glutamic oxaloacetate transaminase (GOT), acid phosphatase (AP), alkaline phosphatase (ALP) and blood glucose concentration in normal rabbits were carried out. All the rabbits used which were of New Zealand strain weighed between 1.00 to 1.60 kg. About 100ml aqueous leaf extract of this plant was administered daily to the test rabbits orally through clean drinking troughs for a period of 15 days. Analyses were conducted using the blood collected intravenously from the larger veins at the back of the ears of rabbits. Aqueous leaf extract of Pride of Barbados did not affect plasma GOT, GPT, AP and ALP activities (P > 0.05). However, plasma glucose concentration increased significantly (P < 0.05) on the 9th, 11th, 13th and 15th days of administration of the aqueous leaf extract to the rabbits. It might be unsafe to abuse the use of this extract as liver tonic as it may create serious health problems for the diabetics due to the likely escalation of complications arising from hyperglycemia. Non – diabetics however, may be placed on a routine check of their fasting blood sugar as they use the aqueous leaf extract of Pride of Barbados.
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