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Articles by I.M. Salman
Total Records ( 3 ) for I.M. Salman
  O.Z. Ameer , I.M. Salman , M.F. Yam , H.H. Abd Allah , M.H. Abdulla , A.M. Shah , A. Sadikun and M.Z. Asmawi
  In the present study, Loranthus ferrugineus was evaluated for blood pressure lowering activity using in vitro and in vivo animal experimental approaches. The fresh aerial parts of the plant were dried, pulverized into powder and successively extracted with petroleum ether, chloroform, ethyl acetate, methanol and water using hot extraction methods. Each of the extracts was dried under reduced pressure using rotary evaporator and subsequently freeze-dried. The effects of three different concentrations (0.5, 1 and 2 mg mL-1 of each extract were examined on isolated rat aortic ring preparations and responses to cumulative doses of noradrenaline (NA) were measured. It was found that the relatively polar methanol extract was the most potent to produce a significant (p<0.05) dose-dependent inhibition in the maximum response and to shift the dose-response curve of NA to the right which suggests that Loranthus ferrugineus methanolic extract (LFME) contains compound(s) with non-competitive inhibitory activity. In another set of experiments, LFME was found to be the most active in blood pressure lowering activity in anesthetized normotensive Sprague Dawley (SD) rat model. Moreover, LFME produced a dose-dependent blood pressure lowering effect. Chemical analysis of LFME showed the presence of significant amounts of polyphenolic and flavonoid constituents. The data suggests that LFME contains some biologically active substances that produce a significant dose-dependent blood pressure lowering effect and vasodilatation is one of the possible mechanisms which may explain its use in the management of hypertension. Furthermore, LFME effects can possibly be attributed to the high polyphenolic contents of this plant.
  I.M. Salman , M.A. Sattar , N.A. Abdullah , O.Z. Ameer , M.H. Abdulla , Md.A.H. Khan and E.J. Johns
  The present study was undertaken to quantify the renal salt and water excretory functions in response to acute unilateral renal denervation in Sprague Dawley (SD) and spontaneously hypertensive (SHR) rats in an attempt to characterize the relative contribution of renal sympathetic nerve activity (RSNA) to renal functional excretory responses in normotensive and hypertensive conditions. Adult male SD and SHR rats were fasted overnight, anesthetized with pentobarbitone sodium (60 mg kg-1 i.p.), denervated by application of phenol to the left renal artery and maintained on an intravenous (i.v.) infusion of normal saline for 2 h. Throughout this period, six urine and plasma samples were collected at 20 min intervals to study kidney function parameters. The data showed that there was a significantly higher (p<0.05) amount of sodium and water excretions in the urine of denervated SD and SHR rats as compared to their innervated counterparts. No significant difference in the renal salt and water excretions was seen between innervated SD and SHR rats; however, the difference was significant (p<0.05) following removal of renal sympathetic input. No appreciable changes in the mean arterial blood pressure (MAP) and plasma sodium (PNa) were observed in denervated SD and SHR rats as compared to the innervated ones; yet, MAP values were significantly higher (p<0.05) in denervated and innervated SHR rats in comparison to the denervated and innervated SD rats. Moreover, PNa in denervated SHR rats, which was significantly higher (p<0.05) in SHR rats as compared to SD rats prior to renal denervation, tended to approximate the one in denervated SD rats. In conclusion, this study confirmed the significant role played by the renal nerves in the control of renal functions. Diuresis and natriuresis are typical responses to acute renal denervation (ARD) in SD and SHR rats. Enhanced salt and water excretion following ARD in SHR rats suggests high renal sympathetic nerve discharge in these animals and highlights the significant contribution of renal nerves to the genetic model of essential hypertension.
  O.Z. Ameer , I.M. Salman , Md. J.A. Siddiqui , M.F. Yam , R.N. Sriramaneni , A.F. Mutee , A. Sadikun , Z. Ismail and M.Z. Asmawi
  The aim of the current investigation was to examine the vascular responsiveness to different extracts obtained from M. cochinchinensis using isolated Sprague Dawley (SD) rat aortic rings preparations. The fresh aerial parts of the plant were dried, pulverized into powder and sequentially extracted with petroleum ether, chloroform, methanol and water using hot extraction method. The effects of three concentrations (0.5, 1 and 2 mg mL-1) of each extract on rat thoracic aorta were tested using cumulative concentrations of noradrenaline (NA). The data showed that all the extracts had the ability to relax vascular smooth muscle; however, high concentrations of the methanol and water extracts caused the most significant (p<0.05) reduction in NA-induced vasoconstriction as compared to petroleum ether and chloroform extracts. Polyphenolic content, HPLC profiling and IR spectra were indicative of the presence of diterpenoid constituents. The results collectively suggested the presence of some biologically active ingredients of possible diterpenoid nature that have the ability to modulate the action of naturally occurring vasoactive agents such as NA on vascular smooth muscle responses in vitro.
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