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Articles by I.M. Alhazza
Total Records ( 5 ) for I.M. Alhazza
  Samir A. Bashandy , I.M. Alhazza and Mohammad Mubarak
  The influence of Zinc (Zn) on Cadmium (Cd) intoxication was investigated in male rats. The exposure of the rats to Cd (2.2 mg kg-1 CdCl2, injected subcutaneously 4 times weekly for 2 months) caused alterations in ultrastructure of liver as manifested by deterioration of mitochondrial cristae, deposition of large amount of collagen fibrils and a hypertrophy of Kupffer cells accompanied by presence of large sized lipid droplets in their cytoplasm. On the other hand, the blood hydroperoxide level, concentrations of Zn, Cd and reduced Glutathione (GSH) in the liver were increased during the treatment period with Cd. On the other hand, blood GSH level and hepatic catalase activity decreased in the rats injected with Cd. Moreover, treatment with Cd produced significant increases in plasma Aspartate Aminotransferase (AST), Alanine Aminotransferase (ALT), gamma Glutamyl Transferase (γ GT) and alkaline phosphatase activities and bilirubin concentration. Administration of Zn (2.2 mg kg-1 ZnCl2 injected s.c. 4 times weekly for 2 months) one hour prior to cadmium exposure ameliorated the toxic effects of Cd. Zn alleviated the elevation of hydroperoxide level, alterations in ultrastructure of liver and hepatic enzymes and Cd accumulation induced by Cd. We conclude that Zn could serve as a physiological antioxidant against cadmium-mediated oxidative stress.
  A.S.A. Haffor and I.M. Alhazza
  The purpose of the present study was to examine the separate and the combined effects of lead and hyperoxia in adult rats, Ratus ratus on LDH. Thirty-two rats were assigned randomly to control (C) and three experimental groups: lead (BP), hyperoxia (HP) and Hypaeroxia-Lead (HPBP). The mean (±SEM) activity of LDH rose significantly (p<0.05) from 216.41±12.39 U L-1 in control group to 539.28±28, 512.78±16.09 and 465.94±55.88 in BP, HP and HPBP groups, respectively. Therefore, both the separate and the combined effects of heavy metal lead and hyperoxai involve activation of LDH to compensate for cellular changes in the cytoplasm. Based on the results of the present study, it can be concluded that lead induces similar effects to hyperoxia exposure that causes the formation of Reactive Oxygen Species (ROS) which mediate changes in the cytoplasm enzymes such as LDH in rats.
  I.M. Alhazza and A.S.A. Haffor
  Heavy metal toxicity causes impairment of variety of cellular process. Cellular failure to maintain balance between the generation and elimination of reactive molecules results in tissue damage. The purpose of this study was to determine the effects of Lead (BP) toxicity on Free Radicals (FR) production. Sixteen adult rats matched with age were randomly assigned to two groups, control and experimental. The experimental group was injected (IP) 1 mg kg-1 of body weight BP daily for seven days. Mean FR in the control group was 206.13±12.39 CARR U. In BP treated group the mean (±SEM) FR rose to 324.13±12.61 CARR U. The change in FR corresponds to 57% increase in the lead treated group. Thus, BP toxicity exposure mediates mitochondria damage and the subsequent oxidative stress. Based on the results of the present study, it can be concluded that BP toxicity causes elevation of Reactive Oxygen Species (ROS) which mediate inhibition of mitochondrial respiration in rats.
  I.M. Alhazza and Samir A.E. Bashandy
  Diabetes mellitus is a degenerative disease that has deleterious effects on male reproductive function, possibly through an increase in oxidative stress by free radicals. The protection against such deleterious effects can be offerd by antioxidant supplementation. This study aimed to evaluate the significance of treatment of diabetic rats with olive oil in reducing oxidative stress, hyperglycemia, hyperlipidemia and testicular dysfunction induced by alloxan. The diabetic rats exhibited an increase in blood glucose, cholesterol, hydroperoxide levels and sperm abnormalities. Moreover, a significant decrease in the weights of sex organs, plasma testosterone, LH, sperm motility and sperm count was noticed in diabetic animals. Administration of olive oil to diabetic rats exhibited hypoglycemic and hypocholesterolemic effects associated with an improvement of sexual organ weights, hormone levels, sperm quality and sperm count. Furthermore, olive oil reduced the elevation of hydroperoxide level induced by alloxan. Administration of olive oil to normal rats showed hypocholesterolemic effect, a decrease in hydroperoxide level and increase in plasma testosterone level after eight weeks. On the other hand, olive oil has no significant influence on blood glucose, luteinizing hormone (LH) level, weight of sex organs, sperm quality and sperm count of normal rats. These results demonstrate that olive oil may be of advantage in lowering hyperglycemia, hypercholesterolemia, oxidative stress and deleterious effects on male reproductive functions induced by diabetes. It is suggested that the administration of olive oil may be helpful in alleviation of diabetic complications associated with oxidative stress and male reproductive dysfunction.
  I.M. Alhazza
  The present study was conducted to investigate the protective effect of selenium (Sel) against cadmium (Cd) toxicity on liver functions of male rats. The animals were divided into three groups. First group served as control, second group administrated (s.c.) cadmium chloride (2 mg kg-1) and third group injected (s.c.) with Sel (0.35 mg kg-1) and cadmium chloride (2 mg kg-1). Blood samples were collected and eight animals were sacrificed after two, four, six and eight weeks. Blood hydroperoxide, aspartate amino transferase (AST), alanine amino transferase (ALT), alkaline phosphatase (ALP), gamma glutamyl transferase (γ-GT) and bilirubin concentrations were evaluated. Moreover hepatic cadmium and zinc contents were determined using atomic absorption. The treatment of rats with Cd results in a significant increase in AST, ALP, ALT, γ-GT, bilirubin, hepatic zinc and cadmium concentrations. Furthermore, hydroperoxide level elevated significantly. Administration of Sel one hour prior to cadmium exposure ameliorated the toxic effects of Cd. Current study conclude that Sel might be act as antioxidant and protect the liver from oxidative stress induced by Cd.
 
 
 
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