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Articles by I.M. Ahmad
Total Records ( 2 ) for I.M. Ahmad
  I.M. Ahmad and A.M. Wudil
  Despite the fact that Anogeissus leiocarpus has been in use for many decades in the treatment of many illnesses little is known about its phytochemistry and toxicological effect in mammals. This study sought to quantitatively determine its phytochemical constituents and its sub acute toxicological effects at certain doses with a view to recommending continual usage of the plant bark at a define concentration or otherwise and to suggest further research based on the outcome. The concentration of saponins was found to be higher (89.5 mg/100 g) than all other phytochemicals where as that of Glycosides were found to be the least (1.7 mg/100 g). Concentration of alkaloids, tannins, steroids, flavonoids and phenols were 26.7, 29.9, 10.6, 27.3, 5.2 mg/100 g, respectively in the aqueous extract. The activities of Alanine Amino Tranferases (ALT), Aspartate Amino Transferase (AST), Alkaline Phosphatase (ALP) and levels of total and direct biluribin were not significantly higher (p<0.05) in all the groups administered with dosage of up to 200 mg kg-1 b.wt. of the aqueous extract of the bark. However, the studies showed that the bark extract results in no liver toxicity and that is safe for consumption at a dose of up to 200 mg kg-1 b.wt.
  I.M. Ahmad , A.M. Wudil and I. Yunusa
  Despite the fact that leaves of Vitex doniana has been in use for many decades in the treatment of many illnesses, little is known about its effect on serum electrolytes balance in mammals. This study sought to determined the effects of its aqueous leaves extract on serum electrolytes (sodium, potassium, chloride and bicarbonate ions) using standard laboratory methods, following 4 weeks oral administration to 30 albino rats at varied doses (100, 150 200 mg kg-1) with 10 albino rats as control group. The values of serum sodium, potassium, chloride and bicarbonate ions for the control group were 170±.00, 5.3±0.16, 130±2.00, 30±2.00 mMol L-1, respectively. However, significant increase (p<0.05) in serum chloride and bicarbonate ions was found at 100, 150 and 200 mg kg-1 and potassium ion at 150 and 200 mg kg-1, where as sodium ion at only 150 mg kg-1. It can be inferred that Vitex doniana leaves extract at dose of 150-200 mg kg-1 could be toxic. Therefore, like any other drug, it should be taken at a therapeutic dose to be determined, since it has been found to increase electrolytes level and may help in replenishing loses.
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