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Articles by I.K. Matazu
Total Records ( 4 ) for I.K. Matazu
  R.A. Umar , S.W. Hassan , M.J. Ladan , I.K. Matazu , B. Shehu , R.A. Shehu , L.G. Muhammed and F.I. Molabo
  We studied the effects of acute and sub-chronic oral administration of nevirapine, lamivudine and stavudine on liver function in albino rats. Acute administration of nevirapine resulted in significant (p<0.05) increases in activities of Aspartate amino transferase (AST) and Alanine amino transferase (ALT). Total proteins, albumin and globulin were significantly lowered. Upon sub-chronic administration of nevirapine, only AST and ALT activities were significantly raised. Acute administration of lamivudine was associated with significantly (p<0.05) lower albumin and globulin and higher total bilirubin and conjugated bilirubin levels. There were no significant differences (p>0.05) in liver function profiles associated with sub-chronic administration of the drug. However, acute and sub-chronic administrations of stavudine were not associated with significant (p>0.05) changes in liver function profiles. We conclude that while the use of stavudine is safe, acute and sub-chronic oral administration of nevirapine and lamivudine are associated with hepatotoxicity and hepatoprotective agents should be incorporated in the treatment regimens employing these drugs to avert life-threatening complications.
  S.W. Hassan , R.A. Umar , I.K. Matazu , H.M. Maishanu , A.Y. Abbas and A.A. Sani
  The effect of sun, oven and solar drying on the nutrients and non-nutrients composition of leaves of Leptadenia hastata was investigated. All the drying methods were found to significantly decrease (p<0.05) magnesium content in sun (1.49±0.49 mg 100 g-1), followed by oven (1.27±0.06 mg 100 g-1) and the lowest in solar dried (0.93±0.07 mg 100 g-1) leaves compared to fresh sample. Drying methods with exception of oven drying did not significantly (p>0.05) lower lipids content. The drying processes employed significantly (p<0.05) decreased carbohydrate, crude protein, magnesium and moisture content. Potassium, ash and crude fibre were significantly (p<0.05) increased. Oven drying significantly reduced acid value (2.82±0.41%), followed by sun (2.12±0.65%) and solar drying (1.76±0.21%) in decreasing order. Tannins, saponins, volatile oils, saponin glycosides and alkaloids were detected in fresh and dried samples. These compounds with exception of saponins and saponin glycosides (sun and oven dried) decreased in trace amounts upon drying. The results reinforce the growing awareness that the leaves of Leptadenia hastata can contribute useful amounts of nutrients to human diets and reduction of toxic non-nutrients compounds upon drying.
  S.W. Hassan , R.A. Umar , A.A. Ebbo , A.J. Akpeji and I.K. Matazu
  Hepatoprotective activity of 50% ethanolic leaf extracts of Parkinsonia aculeata was evaluated against carbon tetrachloride (CCl4)-induced hepatic damage in rats. The extract at doses of 100, 200 and 300 mg kg-1 body weight were administered orally once daily. Hepatoprotective activity was measured based on biochemical parameters. Significantly (p<0.05) elevated levels of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), total bilirubin (TB) and peroxide value in CCl4-intoxicated rats were restored to normal levels in the animals treated with the extract at doses of 100, 200 and 300 mg kg-1 and CCl4. The levels of total proteins, albumin, vitamins C and E appreciated significantly (p<0.05) in animals treated with different doses of the leaf extracts and CCl4. The effects were dose-dependant. These results suggest the leaf extracts of this plant to have potential therapeutic and preventive efficacies, probably due to its antioxidative effect.
  R.A. Umar , S.W. Hassan , M.J. Ladan , M. Nma Jiya , I.K. Matazu , M.K. Abubakar , U. Nata`ala and K. Abdullahi
  In a prospective cross sectional study, the therapeutic efficacy of chloroquine was assessed in children under the age of five years with uncomplicated P. falciparum malaria in Sokoto, Nigeria, using the in vivo 14 day World Health Organization`s protocol (with some modifications). One hundred and twenty six children aged 2 to 59 months were enrolled, out of which 108 completed the study. Clinical, parasitological and haematological data at study start and end were obtained by standard methods. Children were treated with 25 mg kg-1 body weight over 3 days. Adequate clinical and parasitological response was 72.2%, clinical failure was 23.27 and total treatment failure 27.8%. Because of unacceptably high rate of treatment failures due to diminishing efficacy, chloroquine cannot remain the recommended first line drug for the treatment of P. falciparum malaria in pre-school children in Nigeria and the antimalarial treatment policy change from chloroquine to Artemisin-based combination was necessary and justified. Challenges to the success of the policy for control of malaria morbidity and mortality were discussed.
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