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Articles by I.K. Matazu
Total Records ( 3 ) for I.K. Matazu
  S.W. Hassan , R.A. Umar , H.M. Maishanu , I.K. Matazu , U.Z. Faruk and A.A. Sani
  The effect of solar, sun and oven drying on the nutrients and non-nutrients composition of leaves of Gynandropsis gynandra was determined. Ash content of sun (3.14±0.09%), solar (3.16±0.03%) and oven (3.30±0.08%) dried samples were significantly (p<0.05) increased compared to fresh samples. All the drying methods were found to significantly (p<0.05) lower moisture, carbohydrates and protein. However, crude fibre content was significantly (p<0.05) increased with drying method. Drying method, with exception of oven drying, did not significantly (p>0.05) lower lipid content. Significant (p<0.05) increases of mineral elements upon drying with exception of sodium were observed. Alkaloids, tannins, saponins, saponins glycosides, flavonoids and volatile oils were detected in fresh and dried samples. These phytochemicals detected were found to decrease upon drying to trace amounts. Solar and oven drying were found to significantly reduce acid value from 3.91±0.31 to 1.66±0.06 and 2.69±0.33%, respectively. Solar drying may be the preferred method of drying the leaves of Gynandropsis gynandra as it is faster, more hygienic and preserves the nutrients better.
  R.A. Umar , S.W. Hassan , M.J. Ladan , I.K. Matazu , M. Nma Jiya and H.O. Usman
  Retrospective analysis of the results of haemoglobin genotyping of 1033 cases was conducted at the Haemoglobin Genotyping Laboratory in Sokoto, Nigeria. Haemoglobin genotype determination was performed by cellulose acetate electrophoresis. The results show that 666 (64.5%) were Hb AA, 241 (23.3%) Hb AS, 117 (11.3%) Hb SS, 5.0 (0.48%) Hb AC 2.0 (0.19%) and Hb SC 2.0 (0.19%). We conclude that the prevalence of genes for these haemoglobin variants could be explained on the basis of selection due to evolutionary pressure imposed by malaria in line with malaria theory and theory of balanced polymorphism. The implication of our findings on health care provision and planning in the region is discussed.
  S.W. Hassan , M.J. Ladan , R.A. Dogondaji , R.A. Umar , L.S. Bilbis , L.G. Hassan , A.A. Ebbo and I.K. Matazu
  The leaves of Erythrophleum africanum is known in the arid land of tropical Africa to posses toxicological properties. Phytochemical, acute and sub-acute evaluation of the possible toxicity risk of E. africanum aqueous leaves extracts were investigated in this study. Phytochemical constituents detected in the leaves extracts were saponins (1.16% w/v), cardiac glycosides, tannins (0.17 true tannins and 0.23% w/v pseudotannins), flavonoid glycosides, free flavonoids and alkaloids (4.34% w/v). The Lethal Dose (LD50) of the aqueous leaves extracts was greater than 3000 mg kg-1 per os (orally) in albino rats. Sub-acute administration of the extract for 28 days resulted in significant (p<0.05) changes in some renal and liver indices at 3000 and 2000-3000 mg kg-1 body weight, respectively. Histopathological lesions of the kidney and liver in form of moderate and marked infiltration with necrosis and perivascular lymphocytic cuff were observed. The observed lesions could be due to roles played by liver and kidneys in metabolism of xenobiotics and their elimination from the body. These investigations thus seem to indicate the toxic effects of the aqueous leaves extracts of E. africanum at 2000-3000 mg kg-1. These could be attributed to the combined toxicity of the phytochemical constituents such as tannins, saponins, glycosides and alkaloids.
 
 
 
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