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Articles by I.G. Adanlawo
Total Records ( 2 ) for I.G. Adanlawo
  I.G. Adanlawo and F.A.S. Dairo
  Proximate composition, amino acid profile, mineral and the anti-nutrient constituents of ginger root (Zingiber officinale, Roscoe) were determined. Twenty albino rats (Rattus nervegious) of Wistar strain with weight range 185±1.32-222±3.47 g were divided into five groups of four rats each and administered ethanolic extract of ginger root at 100, 200, 300, 400 and 500 mg mL-1 for a period of 28 days. The weight of the rats and the effect on the activities of aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (AKP) and acid phosphatase (ACP) in tissues such as brain, heart, stomach, small intestine, liver, kidney and serum were evaluated. Ginger contained 5.28±0.43% crude protein (CP), 5.54±0.02% ether extract (EE), 5.97±0.04% ash and 66.26±1.03% total carbohydrate with coefficient of variation range 0.01-0.059%. The oxalate content was 4.55±0.07 mg g-1, phytin 28.83±0.73 mg g-1 while tannin was 0.26±0.06%. Phosphorus was 25.70±1.27%, Na, 40.96±1.95%, K, 37.34±1.18%, Ca, 35.66±1.09%, Mn, 19.60±0.62%, Zn, 4.06±1.99%, Fe, 1.44±0.07 and Cu, 0.76±0.07%. Glutamate had the highest amino acid content (11.17±0.22%) while glycine recorded the lowest (1.15±0.06%). Although the body weights of the rats were not significantly (p>0.05) influenced by the administration of ginger root, aspartate transaminase activity significantly increased (p<0.05) at 100 mg mL-1 for the liver (260.56±21.14 μL-1), brain (275.87±18.11 μL-1), kidney (295.24±30.91 μL-1) and serum (104.30±15.03 μL-1). The alanine transaminase activity was significantly highest (p<0.05) at 200 mg mL-1 for the liver (169.38±25.17 μL-1). It was 115.17±19.25 μL-1 for the brain at 400 mg mL-1 and 108.58±20.40 μL-1 for the heart at 300 mg mL-1 dosage. Serum and kidney had their highest (p<0.05) values of 42.37±5.18 and 112.81±13.09 μL-1, respectively on the control group. Alkaline phosphatase had the highest activity (p<0.05) at 400 mg mL-1 (290.32±27.44 μL-1) for the stomach while small intestine recorded 350.62±33.14 μL-1 at 500 mg mL-1 dosage. The brain and serum had 124.55±25.18 μL-1 at 100 mg mL-1 and 160.08±54.15 μ mL-1 at 400 mg mL-1, respectively. Stomach acid phosphatase recorded the highest (p<0.05) activity (163.07±12.04 μL-1) at 500 mg mL-1, small intestine had 198.95±35.27 μL-1 for the control group while serum indicated the highest value of 66.23±6.04 μ mL-1 at 200 mg mL-1 and 164.29±18.23 μ mL-1 at 100 mg mL-1 and at 200 mg mL-1, respectively. The study conclusively showed that ethanolic extract of ginger root did not have any debilitating effect on tissues such as the brain, liver, stomach, small intestine, kidney and the serum.
  A.P. Igbakin and I.G. Adanlawo
  The effect of solvent extracts (ethanol and normal saline) of the seed of Parimari microphylla was investigated on alloxan induced diabetic rats. Rats were administered orally with 500 mg kg-1 body weight of the extracts over a period of five weeks. Plasma glucose, total lipids and cholesterol levels of the animals were monitored throughout the period of the experiment. Also determined were the tissue cholesterol, total lipids, pyruvate and glycogen. The results shows high level of plasma glucose, total lipids and cholesterol i.e., hyperglycemia, hypperlipidemia and hypercholesterolemia, respectively in all the diabetic treated rats except those administered with the ethanolic extract of P. microphylla (EEPM) which reduced the plasma glucose, total lipids and cholesterol of the diabetic animals significantly (p<0.05). Also the elevated tissue pyruvate, total lipids and cholesterol in the diabetic rats were equally reduced significantly (p<0.05) by EEPM and their reduction is favourably compared to that of the control. EEPM increased the reduced tissue glycogen significantly (p<0.05). These results show that the EEPM possesses antidiabetic properties which can normalise all the alterations associated with metabolites in diabetic animals.
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