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Articles by I.G. Ameh
Total Records ( 4 ) for I.G. Ameh
  I.G. Ameh and J.A. Ajayi
  The legated intestine of some sacrificed experimental wall geckos were systematically examined for gut parasites. 42(60%) of the animals examined (n = 70) were infected with helminthes identified as cestodes of the family proteocephalidae, which infected 29(41.4%) of the geckos and nematodes of the family pharyngodonidae, which infected 21(30.0%) of the geckos, respectively. The polyzoic cestode organism had typical features of the platyhelminth parasites, which commonly infect man and domestic animals. The nematodes however, had prominent tails and respectively, species seen were morphologically indistinguishable from Thelandros bulbosus, T. mule and a Stongyluris species, except for dissimilar genital apparatus and reduced caudal alae. Some speculations were made to suggest the phylogenic link of gecko parasites with related human parasites in their developmental history. It was concluded that these gecko parasites were of potential zoonotic risk to man and domestic animals, because of their morphological similarity to the human parasites and for the sharing of common domestic abode by man and the gecko.
  Opara W.E.K. and I.G. Ameh
  Skin ulcer healing-time was observed in forty patients of Cutaneous leishmaniasis given surgical or drug treatment of various types. It took averages of two to five weeks (±1.41) and a maximum of nine weeks for ulcer of any of 22 patients who took mectizan (200-400 μg) to heal, leaving pale but smooth skin with no disfiguring cicatrix. This is a significantly (p<0.05) better result than an average of ten and half weeks (±4.95) ulcer healing-time observed in 14 patients treated with surgical curettage and wound dressing but no mectizan administration. Another 4 patients who took dapsone or rifampicin did not respond to treatment. It was concluded that mectizan showed promise and reliability when combined with surgical wound dressing to cure Cutaneous leishmaniasis.
  E.U. Etuk , H.A. Suberu , I.G. Ameh and K. Abubakar
  The aqueous leaf extract of Pterocarpus erinaceus (Leguminoceae) was investigated for possible antimycotic effect in Sprague dawley rats. The extract was tested against moulds (Aspergillus niger and Aspergillus flavus) and dermatophytes (Trichophyton rubrum and Microsporum gypseum). The extract at 20-40 mg kg-1 body weight significantly (p<0.05) and dose dependently inhibited the growth rate of the moulds and dermatophytes by over 60 and 97%, respectively. In the in vivo study, there was also a significant reduction in the number of dermatophyte spores recovered from the infected sites treated with the extract as compared with the non treated sites. The extract produced no sign of acute toxicity or death when a limit dose of 2 g kg-1 body weight was administered orally in rats. Collectively, these results suggest that the extract possess antimycotic effect and appears to be safe when given orally at a limit dose of 2 g kg-1 body weight of the rats. This therefore supports the use of Pterocarpus erinaceus leaf extract traditionally for the treatment of fungal skin diseases.
  I.G. Ameh and W.E.K. Opara
  In the present study 1694 cases of typhoid in Sokoto of Northern Nigeria, were analyzed based on the examination of monthly medical record at the Usmanu DanFodiyo University Teaching Hospital. The result shows that 531 (31.4%) of the patients were admitted (in patients) while 1162 (68.6%) of the patients were treated for typhoid at the out patient department of the hospital during the study period. Of those admitted, more males (313 or 58.9%) than females (218 or 41.1%) were affected, but sex-related difference in infection rates did not vary significantly (P>0.05). The fatality rate (1.5%) was due mainly to intestinal perforation (3.4%) and meningitis (1.2%). Young adults of 11-20 years and adolescents of 21-30 years age grades were the most vulnerable members of the community and disease prevalence rates among them were 36.5 and 31.6%, respectively. Computed F-statistic suggested that there was a uniform yearly increase (P< 0.05) in number of cases and this was probably due to improved diagnosis and increased awareness, which enhanced case presentations at the hospital. In a follow-up study, an unstructured interview and questionnaire survey among health workers in local health institutions indicated that the predisposing factors for typhoid in study area were related mainly to personal, food, drinking-water and environmental hygiene and these persisted throughout the months of the study years.
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