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Articles by I.A. Oreagba
Total Records ( 3 ) for I.A. Oreagba
  O.I. Iribhogbe , E.O. Agbaje , I.A. Oreagba , O.O. Ain and A.D. Ota
  Malaria infection has been associated with a decrease in hematological parameters. This is linked to micronutrient deficiency which is associated with increasing severity of infection. The present study involves an in vivo evaluation of the role of some selected antioxidant micronutrients in the modulation of hematological profile in malaria infection. Rodent malaria model using Plasmodium berghei NK-65 strain (chloroquine sensitive) was used. A 4 day curative test was conducted using 45 mice of either sex with a mean weight of 20.05±0.02 g. Fourty mice were inoculated intraperitoneally with 1x107 million Plasmodium berghei infected erythrocyte and were administered with 0.2 mL of distilled water, 0.2 mL of vehicle; Tween 80 (control and vehicle group), chloroquine 25 mg kg-1 and artesunate 4 mg kg-1 (standard drug group), vitamin A 60 mg kg-1, vitamin E 100 mg kg-1, selenium 1 mg kg-1, zinc 100 mg kg-1 (test group F, G, H and I, respectively) 72 h post inoculation. Results showed a statistically (p<0.05) significant difference in total White Blood Cell count (WBC) in the vitamin A, E, selenium and zinc treated groups when compared with apparently healthy non-inoculated control. Additionally, there was a significant increase in MCHC in the zinc treated group when compared to apparently healthy uninfected control (34.21±0.29 g dL-1 versus 31.88±0.63 g dL-1; p<0.05). In conclusion, use of antioxidant micronutrients as adjuvant may help improve hematological parameters in malaria induced anemia in addition to modulating cell mediated immune response.
  O.I. Iribhogbe , E.O. Agbaje , I.A. Oreagba , O.O. Aina and A.D. Ota
  Micronutrients are known to have antioxidant activity; however, its role in plasmodial infection is still not clearly defined. The present study involves an in vivo evaluation of the role of some selected antioxidant micronutrients in the therapeutics of malaria. In this study, rodent malaria model using Plasmodium berghei NK-65 strain (chloroquine sensitive) was used. Fourty five mice of either sex weighing 20.05±0.02 g were used for the study. Fourty mice were inoculated intraperitoneally with 1x107 million Plasmodium berghei infected erythrocyte and were administered with 0.2 mL of distilled water, 0.2 mL of vehicle; Tween 80 (control and vehicle group), chloroquine 25 mg kg-1 and artesunate 4 mg kg-1 (standard drug group), vitamin A 60 mg kg-1, vitamin E 100 mg kg-1, selenium 1 mg kg-1, zinc 100 mg kg-1 (test group F, G, H and I, respectively) 72 h post inoculation. Antioxidant micronutrients demonstrated significant (p<0.05) chemosuppressive activity when compared with negative control during the 4 day curative test. Mean parasitemia was significantly reduced (p<0.05) in the micronutrient treated groups after the 4 day curative test when compared with negative control. This however, was also significant between micronutrient treated groups (F = 17.88; p = <0.05). Catalase and glutathione peroxidase activity was significantly (p<0.05) higher in the vitamin A, E, selenium and zinc treated groups, respectively when compared to apparently healthy uninfected control. Conclusively, antioxidant micronutrients have antimalarial activity and may be of benefit in malaria therapeutics.
  O.I. Iribhogbe , E.O. Agbaje , I.A. Oreagba , O.O. Aina and A.D. Ota
  Free radical production from oxidative stress induced by malaria infection plays a major role in the pathogenesis of malaria. However, the use of agents with antioxidant activity may interfere with malaria progression. The study involves an in vivo evaluation of the role of some antioxidant micronutrients in the modulation of malaria infection. Rodent malaria model using Plasmodium berghei NK-65 strain (chloroquine sensitive) was used for the study. Fourty five mice of either sex weighing 20.05±0.02 g were procured for the study. Fourty mice were inoculated intraperitoneally with 1x107 million Plasmodium berghei infected erythrocyte and were administered with 0.2 mL of distilled water, 0.2 mL of vehicle; Tween 80 (control and vehicle group), chloroquine 25 mg kg-1 and artesunate 4 mg kg-1 (standard drug group), vitamin A 60 mg kg-1, vitamin E 100 mg kg-1, selenium 1 mg kg-1, zinc 100 mg kg-1 (test group F, G, H and I, respectively) 72 hours post inoculation. Antioxidant micronutrients demonstrated significant (p<0.05) schizonticidal activity when compared with negative control during the 4 day curative test. Erythrocyte membrane distability was most markedly elevated in the tween 80 group (426.15%), followed closely by the chloroquine (373.85%) treated group and artesunate group (329.23%) and least in the zinc treated group (32.31%). There was no significant (p>0.05) difference in MCFI values (0.115±0.002; 0.114±0.002 g dL-1) between vitamin A treated group and selenium treated group respectively. However, this was significant (p<0.05) between the micronutrient treated groups and the control (negative, positive and vehicle). Conclusively, antioxidant micronutrients have antimalarial activity which may be due potentiation of erythrocyte membrane stabilization.
 
 
 
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