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by
I. Somasundaram |
Total Records (
4 ) for
I. Somasundaram |
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T.S. Shanmugarajan
,
M. Arunsundar
,
I. Somasundaram
,
E. Krishnakumar
,
D. Sivaraman
and
V. Ravichandiran
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The current communication was designed to assess the
cardioprotective effect of the methanolic leaf extract of Ficus hispida
Linn. (FH) (400 mg kg-1 body weight, administered orally
for 10 days) on cyclophosphamide (CP) provoked oxidative injury in rat
heart. CP cardiotoxicity, induced by single intraperitoneal injection
(200 mg kg-1 b.wt.), was revealed by elevated serum creatine
phosphokinase (CPK), lactate dehydrogenase (LDH), aspartate transaminase
(AST) and alanine transaminase (ALT). CP induced rats, treated with FH
depicted near normalcy in these parameters. In the CP group, increased
oxidative stress was evidenced by a significant rise in myocardial malondialdehyde
(MDA) level and decline in superoxide dismutase (SOD), catalase (CAT),
glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase
(GST) and reduced glutathione (GSH) activities in the heart tissue. FH
treated rats displayed a significant inhibition of lipid peroxidation
(LPO) and augmentation of endogenous antioxidants. These results give
credence to the notion that treatment with F. hispida leaf
extract ameliorates CP induced cardiotoxicity and might serve as a novel
combination therapy with CP to combat oxidative stress-mediated myocardial
injury. |
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T. S. Shanmugarajan
,
E. Krishnakumar
,
I. Somasundaram
,
D. Sivaraman
,
M. Arunsundar
,
R. Balaji
and
S. M. Sivakumar
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In the present study, we evaluated the effect of Ferulic Acid (FA) supplementation (20 mg kg-1 body weight) on GalN provoked hepatotoxicity in male Wistar rats. Hepatotoxicity was induced by a single intraperitoneal injection of GalN (500 mg kg-1 body weight) and manifested by an increase in the levels hepatospecific marker enzymes like Aspartate Transaminase (AST), Alanine Transaminase (ALT), Alkaline Phosphatase (ALP) and Lactate Dehydrogenase (LDH). In contrast, pretreatment with FA significantly ameliorated all these alterations. GalN intoxicated rats visualize a remarkable oxidative stress, as evidenced by a significant elevation in Lipid Peroxidation (LPO) with a concomitant decrease in the glutathione (GSH) activity. These changes were coupled with a marked decline in the activities of enzymic antioxidants [superoxide dismutase (SOD), catalase (CAT), Glutathione Peroxidase (GPx) and Glutathione Reductase (GR)] in the liver tissue of GalN administered rats. FA pretreated rats exhibit a significant inhibition of LPO and augmentation of endogenous antioxidants. Further, there was an increase in the levels of cholesterol, triglycerides and free fatty acids followed by a decrease in the levels of phospholipids in serum and liver. Pretreatment with FA reversed these alterations to near normal. Results of this study revealed that FA could afford a significant protection in the alleviation of GalN induced hepatocellular injury. |
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T.S. Shanmugarajan
,
M. Arunsundar
,
I. Somasundaram
,
D. Sivaraman
,
E. Krishnakumar
and
V. Ravichandran
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The current study was designed to scrutinize the putative
hepatoprotective potential of the methanolic leaf extract of Ficus
hispida Linn. (FH) (400 mg kg-1 body weight) on cyclophosphamide
(CP) elicited oxidative injury in rat liver. CP administration (150 mg
kg-1 body weight, i.p., twice, in 2 consecutive days) caused
liver injury, featuring substantial increase in serum aspartate transaminase
(AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate
dehydrogenase (LDH), gamma-glutamyl transpeptidase (GGT) and bilirubin
levels. In contrast, treatment with FH significantly precluded all these
alterations. CP intoxicated rats depicted a remarkable oxidative stress,
as evidenced by a significant elevation in lipid peroxidation (LPO) with
a concomitant decrease in the GSH activity. These changes were coupled
with a marked decline in the activities of enzymic antioxidants [superoxide
dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase
(GST) and glutathione reductase (GR)] in the liver tissue of CP-administered
rats. FH treated rats displayed a significant inhibition of lipid peroxidation
(LPO) and augmentation of endogenous antioxidants. Taken together, these
findings emphasize the hepatoprotective effect of F. hispida
leaf extract against CP-induced oxidative liver injury. Hence, F.
hispida might serve as a promising medicinal herb in complementary
chemotherapeutic modalities. |
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T.S. Shanmugarajan
,
M. Niladri
,
I. Somasundaram
,
N. Prithwish
,
Soncharan Patel
and
K. F. H. Nazeer Ahamed
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Adjuvant arthritis is one of the extensively used models of chronic inflammatory
joint disorder such as rheumatoid arthritis. It is postulated that oxidative stress
plays a pivotal role in rheumatoid arthritis. The current research was designed
to examine the antioxidative effect of Gaultheria fragrantissima Wall.
(Ericaceae) against complete Freund’s adjuvant induced arthritis. Arthritis
was induced by single subcutaneous injection of complete Freund’s adjuvant
(0.1mL) into the plantar surface of the right hind paw of male Wistar rats. Gaultheria
fragrantissima leaf extracts (100 and 200mg kg−1day−1)
and indomethacin (3mg kg−1day−1) were administered
orally for 14 days (from day 14 to day 28) after the adjuvant injection. The protective
effect was evaluated by DPPH radical scavenging activity, alterations in paw volume,
lipid peroxidation (measured in terms of MDA), antioxidant, enzymatic (SOD, CAT,
GPx, GR and GST), nonenzymatic (GSH), and marker enzymes (AST, ALT, ALP and GGT)
levels from liver and serum of adjuvant induced and treatment groups. These biochemical
alterations were significantly (p<0.05) ameliorated nearly to control
values after administration of Gaultheria fragrantissima leaf extract to
arthritic animals. |
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