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Articles by I. Somasundaram
Total Records ( 4 ) for I. Somasundaram
  T.S. Shanmugarajan , M. Arunsundar , I. Somasundaram , E. Krishnakumar , D. Sivaraman and V. Ravichandiran
  The current communication was designed to assess the cardioprotective effect of the methanolic leaf extract of Ficus hispida Linn. (FH) (400 mg kg-1 body weight, administered orally for 10 days) on cyclophosphamide (CP) provoked oxidative injury in rat heart. CP cardiotoxicity, induced by single intraperitoneal injection (200 mg kg-1 b.wt.), was revealed by elevated serum creatine phosphokinase (CPK), lactate dehydrogenase (LDH), aspartate transaminase (AST) and alanine transaminase (ALT). CP induced rats, treated with FH depicted near normalcy in these parameters. In the CP group, increased oxidative stress was evidenced by a significant rise in myocardial malondialdehyde (MDA) level and decline in superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione reductase (GR), glutathione-S-transferase (GST) and reduced glutathione (GSH) activities in the heart tissue. FH treated rats displayed a significant inhibition of lipid peroxidation (LPO) and augmentation of endogenous antioxidants. These results give credence to the notion that treatment with F. hispida leaf extract ameliorates CP induced cardiotoxicity and might serve as a novel combination therapy with CP to combat oxidative stress-mediated myocardial injury.
  T. S. Shanmugarajan , E. Krishnakumar , I. Somasundaram , D. Sivaraman , M. Arunsundar , R. Balaji and S. M. Sivakumar
  In the present study, we evaluated the effect of Ferulic Acid (FA) supplementation (20 mg kg-1 body weight) on GalN provoked hepatotoxicity in male Wistar rats. Hepatotoxicity was induced by a single intraperitoneal injection of GalN (500 mg kg-1 body weight) and manifested by an increase in the levels hepatospecific marker enzymes like Aspartate Transaminase (AST), Alanine Transaminase (ALT), Alkaline Phosphatase (ALP) and Lactate Dehydrogenase (LDH). In contrast, pretreatment with FA significantly ameliorated all these alterations. GalN intoxicated rats visualize a remarkable oxidative stress, as evidenced by a significant elevation in Lipid Peroxidation (LPO) with a concomitant decrease in the glutathione (GSH) activity. These changes were coupled with a marked decline in the activities of enzymic antioxidants [superoxide dismutase (SOD), catalase (CAT), Glutathione Peroxidase (GPx) and Glutathione Reductase (GR)] in the liver tissue of GalN administered rats. FA pretreated rats exhibit a significant inhibition of LPO and augmentation of endogenous antioxidants. Further, there was an increase in the levels of cholesterol, triglycerides and free fatty acids followed by a decrease in the levels of phospholipids in serum and liver. Pretreatment with FA reversed these alterations to near normal. Results of this study revealed that FA could afford a significant protection in the alleviation of GalN induced hepatocellular injury.
  T.S. Shanmugarajan , M. Arunsundar , I. Somasundaram , D. Sivaraman , E. Krishnakumar and V. Ravichandran
  The current study was designed to scrutinize the putative hepatoprotective potential of the methanolic leaf extract of Ficus hispida Linn. (FH) (400 mg kg-1 body weight) on cyclophosphamide (CP) elicited oxidative injury in rat liver. CP administration (150 mg kg-1 body weight, i.p., twice, in 2 consecutive days) caused liver injury, featuring substantial increase in serum aspartate transaminase (AST), alanine transaminase (ALT), alkaline phosphatase (ALP), lactate dehydrogenase (LDH), gamma-glutamyl transpeptidase (GGT) and bilirubin levels. In contrast, treatment with FH significantly precluded all these alterations. CP intoxicated rats depicted a remarkable oxidative stress, as evidenced by a significant elevation in lipid peroxidation (LPO) with a concomitant decrease in the GSH activity. These changes were coupled with a marked decline in the activities of enzymic antioxidants [superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), glutathione-S-transferase (GST) and glutathione reductase (GR)] in the liver tissue of CP-administered rats. FH treated rats displayed a significant inhibition of lipid peroxidation (LPO) and augmentation of endogenous antioxidants. Taken together, these findings emphasize the hepatoprotective effect of F. hispida leaf extract against CP-induced oxidative liver injury. Hence, F. hispida might serve as a promising medicinal herb in complementary chemotherapeutic modalities.
  T.S. Shanmugarajan , M. Niladri , I. Somasundaram , N. Prithwish , Soncharan Patel and K. F. H. Nazeer Ahamed
  Adjuvant arthritis is one of the extensively used models of chronic inflammatory joint disorder such as rheumatoid arthritis. It is postulated that oxidative stress plays a pivotal role in rheumatoid arthritis. The current research was designed to examine the antioxidative effect of Gaultheria fragrantissima Wall. (Ericaceae) against complete Freund’s adjuvant induced arthritis. Arthritis was induced by single subcutaneous injection of complete Freund’s adjuvant (0.1mL) into the plantar surface of the right hind paw of male Wistar rats. Gaultheria fragrantissima leaf extracts (100 and 200mg kg−1day−1) and indomethacin (3mg kg−1day−1) were administered orally for 14 days (from day 14 to day 28) after the adjuvant injection. The protective effect was evaluated by DPPH radical scavenging activity, alterations in paw volume, lipid peroxidation (measured in terms of MDA), antioxidant, enzymatic (SOD, CAT, GPx, GR and GST), nonenzymatic (GSH), and marker enzymes (AST, ALT, ALP and GGT) levels from liver and serum of adjuvant induced and treatment groups. These biochemical alterations were significantly (p<0.05) ameliorated nearly to control values after administration of Gaultheria fragrantissima leaf extract to arthritic animals.
 
 
 
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