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Articles by I. Patimah
Total Records ( 2 ) for I. Patimah
  B. Sahar Ansari , R. Vasudevan , M. Mirinargesi , I. Patimah , A.R. Sabariah , P. Pasalar and Ali Bakhshi
  Problem statement: Glutathione S-transferase is super family genes that encode enzymes which involve in the detoxification of the cell and protects DNA from damage. Conflicting results was found in several studies in association with GSTT1 and GSTM1 gene polymorphisms and prostate cancer. In this study, we determined the association between the GSTT1 and GSTM1 gene polymorphism and prostate cancer in Iranian subjects as control with control subjects. Approach: Sixty number of sample were collected from both case and control at Milad hospital, Tehran, Iran who were above 40 years of old. Genomic DNA was extracted from blood and the detection of GSTT1 and GSTM1 genotypes was done using multiplex PCR method. Results: The frequency of the null alleles in GSTT1 and GSTM1 was 15 and 41.66% respectively in prostate cancer patients and 21.66 and 56.66% respectively in control subjects. There was no association was found between the polymorphism and prostate cancer among Iranian subjects (p>0.05). Conclusion: This study failed to show an association with GSTT1 and GSTM1 gene polymorphisms and prostate cancer and has no susceptibility to Iranian prostate cancer subjects.
  M.E.T. Manal , P. Hanachi , I. Patimah , I.A. Siddig and O. Fauziah
  This study evaluates the chemopreventive effect of an aqueous extract of fresh leaves of Azadarichta indica against liver cancer. Twenty male rats (Spraque dawley), 150-250 g, were acclimatized for 1 week before use. The rats were divided randomly into 4 groups; cancer control group (C), cancer treated with 5% Azadarichta indica extract group (CAI), normal control group (N) and normal treated with 5% Azadarichta indica extract group (NAI) and each group contains 5 rats. Rats in group C and CAI were induced cancer by intraperitoneal injection of 200 mg kg-1 diethyl nitrosamine (DEN) as hepatocarcinogenesis initiator and then followed by 2-acetylaminofluorene as promoter of hepatocarcinogenesis (0.02% in food) for 2 weeks. The rats were then left for 2 weeks. The rats in group N and NAI were injected once intraperitoneally with corn oil and act as control. The plant was fed orally to CAI and NAI groups. Serum concentration of alpha-fetoprotein (AFP) as liver tumor marker was measured. Glutathione S-transferase (GST) and glutathione peroxidase (GPx) were measured in the serum and liver cytosol. The results of this study revealed that there is a significant difference (p≤0.05) between C and CAI groups in serum alpha-fetoprotein and, in serum and liver cytosol levels of glutathione S-transferase and glutathione peroxidase. While there was no significant difference (p0.05) between NAI and N group in GST and GPx level. As a conclusion from this study that the consumption of 5% of NEEM leaves aqueous extract resulted in complete inhibition of chemically induced hepatocarcinogenesis in Spraque dawley rats.
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