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Articles by I. Okoli
Total Records ( 3 ) for I. Okoli
  E.S. Amadi , C.A. Oyeka , I. Okoli , J.I. Ihedioha and I.R. Iroha
  The possible curative and preventive effect of Baphia nittida extract on insipient caries and caries-free rats were investigated. About 200 mg mL-1 of Baphia nittida extract were intra-orally administered to the teeth surfaces of different rat groups. Evidence of development of caries was determined by direct observation, probing, microbial count and radiography. The result of the study showed that there was no evidence of dental caries among the non-insipient caries rat groups fed simultaneously with 70% sucrose-in-diet and extract of Baphia nittida. Similarly, the rat groups having insipient caries did not exhibit signs of dental caries after the administration of Baphia nittida extract. There was a significant difference (p<0.05) between the pre and post microbial count of the insipient caries rat groups given Baphia nittida extract. Also, there was a significant difference (p<0.05) between the pre and post microbial count of the caries-free rat groups given Baphia nittida extract twice daily. The result generally suggested that Baphia nittida extract has in vivo preventive and curative potential on dental caries in rats simultaneously fed with 70% sucrose-in-diet.
  E.S. Amadi , A. Oyeka , R.A. Onyeagba , I. Okoli and O.C. Ugbogu
  The antimicrobial effect of cold water, hot water and ethanolic extracts of Spondias mombin and Baphia nittida on cariogenic streptococci isolated from dental caries patients attending the Ebonyi State University Teaching hospital dental clinic Abakaliki was investigated using the agar well diffusion technique. The cold water and ethanolic extracts of Baphia nittida showed inhibition zone diameter (IZD) of 10 and 12 mm respectively at 400 mg mL -1, while the hot water showed no inhibitory effect. All extracts of Spondias mombin did not inhibit the test organism. The cold water and ethanolic extracts of Baphia nittida showed Minimum Inhibitory Concentration (MIC) of 100 and 50 mg mL -1 respectively. The combination of the cold water extracts of the two herbs showed enhanced activity of 13 mm. Phytochemical analysis of Baphia nittida revealed the presence of flavonoids, glycosides, proteins saponins, tannins, carbohydrate and steroidal aglycone. Acute toxicity testing of Baphia nittida at a range of 250-5000 mg kg -1 bw using mice showed no clinical signs of acute toxicity. No chemical toxicity was observed amongst rats given Baphia nittida extracts 500 and 1000 mg kg -1 bw after 30 days. Baphia nittida may be a potential source of an antimicrobial agent for the treatment and management of dental caries.
  E.S. Amadi , C.A. Oyeka , I. Okoli , J.I. Ihedioha and I.R. Iroha
  The study investigated the caries inductive capacities of different sucrose concentrations and the anti-caries activity of Breynia nivosus extract in experimental albino rats. Different concentrations (70, 50, 30 and 10%) of sucrose-in-diet, were respectively fed to caries-free albino rats harboring Streptococcus rattus in their oral cavity, to determine their caries induction effect. Subsequently, 200 mg mL-1 of Breynia nivosus extract were intra-orally administered to the teeth surfaces of caries-free and non caries free rats to ascertain its possible caries curative and/or preventive effects. Direct observation, probing, microbial count and radiography were used to monitor the caries status of the rats. There were significant increase (p<0.05) in the microbial count of dental plaque of rat groups fed with 70, 50 and 30% sucrose-in-diet. However, milky white spots were only observed among the rat groups fed with 70 and 50% sucrose-in-diet at the 6th week of observation. The results of this investigation suggests that Breynia nivosus extract possesses some degree of in vivo caries preventive and curative effect on the teeth surfaces of albino rats fed simultaneously with 70% sucrose-in-diet.
 
 
 
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