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Articles by I. Jahan
Total Records ( 2 ) for I. Jahan
  M. Abu-Tayyeb , I. Jahan , M.A. Hossain , M.M. Hossain , N. Akter and B.K. Nath
  Objective: This experimental study was conducted to investigate the effects of diets and enzyme supplementation on the live weight (LW), feed intake (FI), feed conversion ratio (FCR), viability, leg bone quality and meat yield traits of broilers. Materials and Methods: In a 2×2 factorial experiment, having two diet types [corn-soya meal (CSM) based and corn-wheat-soya (CWS) based] and two enzymes levels (with or without), Broiler chicks (n = 112; Ross308) were assigned to four dietary treatments (CSM-, CSM+, CWS- and CWS+) with four replicates, seven chicks per replicate in a CRD. The chicks were fed on the ready-made broiler diet up to 25 days, after that formulated diets were supplied the birds ad libitum up to 45 days. All the diets were iso-caloric and iso-nitrogenous in nature and supplemented with or without enzymes in mash form. Results: Data revealed that diets (CSM- and CWS-) had no significant effect (p>0.05) on the LW, FI and FCR of broilers but enzymes (CSM+ and CWS+) increased (p<0.5, p<0.01) the LW and FI on day 45. Enzyme, diet and their interaction had no influence (p>0.05) on the viability, latency-to-sit (LTS), gait-scoring (GS) and bone traits of broilers. Diet and their interaction had no influence (p>0.05) on the bone quality traits of broilers except for enzyme. The mineral concentration (Ca%) and other bone traits were increased (p<0.05) by enzymatic diets. The results of dressing percentage, drumstick weight, thigh weight, breast weight, wing weight, back weight, shank weight and neck weight percentage of broilers were unaffected (p>0.05) by enzyme, diet and their interaction. Enzyme and diet had no influence (p>0.05) over the breast weight but its interaction influenced (p<0.05) the breast weight (%) of birds. Giblet and back weights (%) were influenced (p<0.05) by the diet only. Conclusion: It could be concluded that broilers might respond positively to enzymatic diets at the later stage of production.
  Mst. M. Begum , M.S. Rahman , R.R. Swarna , M. Das , A.H.M.R. Imon , I. Jahan , M. Rahman , Md. E. Haque , R.R. Saha , A.H.M. Quamruzzaman , Md. A. Obaida , M. Maniruzzaman , A. Islam , Md. T. Islam and A. Sarker
  Background and Objective: Combination of dosages regimen of an antidiabetic agent (Glibenclamide) with a lipid lowering drug can be an effective medication for the patient with high blood glucose level and liver enzyme disfunctionality. The present study was undertaken to investigate the effect of a fixed dose combination of glibenclamide (1.2 mg/70 kg b.wt.) and simvastatin (10 mg/70 kg b.wt.) on blood glucose and liver enzymes dysfuntionality in alloxan-induced diabetic rats for an extended time period. Materials and Methods: Two protocols were developed to carry out the experiment. The first is designated as 4 weeks short-term and second one is termed as 12 weeks long-term treatment protocols, respectively. Diabetes Mellitus (DM) was induced by single intraperitoneal (i.p.) injection of freshly prepared alloxan solution in 0.9% saline. Diabetic rats received treatment with i.p., injection of glibenclamide (1.2 mg/70 kg b.wt.) and simvastatin (10 mg/70 kg b.wt.) for 4 weeks as monotherapy and combination therapy (glibenclamide 0.6 mg/70 kg b.wt., simvastatin 5 mg/70 kg b.wt.) for 12 weeks. Graph pad was used and the results were expressed as Mean±SEM. A one-way analysis of variance (ANOVA) followed by Dunnett’s post hoc test or students paired or unpaired t-test was used in the study where appropriate. Results: Results were considered to be significant when p-values were less than 0.05 (p<0.05). Combination therapy demonstrated a significant (p<0.05) decrease in blood glucose and liver enzymes elevation compared with diabetic control group. The study also demonstrated that the short term treatment has satisfactory effect on lowering SGPT by 41% and SGOT by 50%. Long term administration of combination therapy showed more significant (p<0.05) potentiality on lowering SGPT (46%) and SGOT (53%), respectively and this level remain steady during total treatment period. Conclusion: The present study demonstrates that combination of glibenclamide with simvastatin at the dose level tested exhibits significant glucose and liver enzymes lowering activity in alloxan induced diabetic rats. When monotherapy with oral antidiabetic agents fails, combination therapy with glibenclamide plus simvastatin seems to be stable and effective for the treatment of diabetes mellitus.
 
 
 
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