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Articles by I. Ali
Total Records ( 2 ) for I. Ali
  M. A. Ganie , B. A. Laway , S. Nisar , M. M. Wani , M. L. Khurana , F. Ahmad , S. Ahmed , P. Gupta , I. Ali , I. Shabir , A. Shadan , A. Ahmed and S. Tufail
  Aims  Wolfram syndrome, also known as DIDMOAD, is a relatively rare inherited neurodegenerative disorder, first evident in childhood as an association of juvenile-onset diabetes mellitus and optic atrophy, followed by diabetes insipidus and deafness. The aim of the study was to examine the clinical profile of patients with DIDMOAD syndrome presenting to a tertiary care hospital in north India.

Methods  Clinical presentation of juvenile-onset diabetes mellitus fulfilling the diagnosis of Wolfram syndrome was studied using a prepared standardized form.

Results  Subjects with juvenile-onset non-autoimmune diabetes mellitus attending the diabetic clinic at a tertiary care centre in north India were followed for 10 years and a diagnosis of fully developed Wolfram syndrome was confirmed in seven individuals. The series consisted of five male and two female patients with a mean age of 17.5 ± 7.34 years. Two subjects had consanguinity and none had any other family member affected. Optic atrophy was present in all, sensorineural hearing loss in 4/7, central diabetes insipidus in 4/7 and nephrogenic diabetes insipidus in 2/7 subjects. The new associations found were: spastic myoclonus, short stature with pancreatic malabsorption, nephrogenic diabetes insipidus, cyanotic heart disease and choledocholithiasis with cholangitis. Genetic analysis revealed mutation in exon 8 of the WFS1 gene in all the cases studied.

Conclusions  The present clinical series of Wolfram syndrome reveals a varied clinical presentation of the syndrome and some new associations.

  M. Ramzan , I. Ali and A. Matin
  Childhood obesity is escalating rapidly, both in industrialized and developing countries. It will emerge as a potential public health burden faced by the developing countries in the near future. In children, Non Alcoholic Fatty Liver Disease (NAFLD) is mainly associated with obesity and metabolic syndrome and is therefore considered as a metabolic complication of obesity. NAFLD comprises of a range of chronic liver diseases from simple steatosis, steatohepatitis and cirrhosis with liver failure. Since the prevalence of obesity in children is increasing, the prevalence of NAFLD in children is expected to increase as well. Prevention of obesity and identification of children with an increased risk of NAFLD are important steps in preventing irreversible liver damage. This prospective study was carried out in the primary schools of Dera Ismail Khan History City having mixed population. Clinical examination of the children excluded those suffering from chronic health ailments. History from the parents excluded the intake of hepatotoxic drugs. Body mass status of child was determined according to World Health Organization s' criteria and Centers for Disease Control and Prevention (CDC)'s gender and age specific growth charts. Randomly selected normal weight and obese children have undergone abdominal ultrasound examination to confirm or rule out hepatic steatosis (Fatty Liver) by detecting the alteration in ultrasound/hyperechogenicity of the organ. Randomly selected children (normal weight and obese) among the 1336 school going children were subjected to ultrasound examination, comprising of 55 boys (59.13%) and 38 (40.86%) girls. 67 (72.04%) were obese and 26 (27.95) as normal weights. Hepatic ultrasound alterations/hyperechogenic liver was found in 7 (7.52%) obese boys. None of the obese girls and normal weight children was found to exhibit any alteration in ultrasound findings.
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